Changes

=== Synergistic and antagonistic effect of aushadha ===

=== Synergistic and antagonistic effect of aushadha ===

<div style='text-align:justify;'>The action of aushadha may either increase or decrease when used in combination with other aushadha. It may show a synergistic effect with combined positive interactions with other ingredients. Their combined effect is greater than the sum of the effects seen when each aushadha is given alone. A synergism can be observed in the combination of ''Momordica charantia'' (Bitter guard) and conventional hypoglycaemic drugs. ''Momordica charantia''  extract when clinically co-administered with 50% of the full clinical  doses  of  allopathic  or  conventional drugs,  metformin  and  glibenclamide,  greater hypoglycemic  (decreased  serum  glucose)  effect  was  observed  in  patients  as  compared to  full clinical doses of metformin or glibenclamide alone thereby exhibiting additive and synergy effects.</br>On the contrary, the aushadha may also show an antagonistic effect in which one aushadha decreases or nullifies the action of other aushadha. For example, in the formulation lashuna ksheerapaka, lashuna (Allium sativum) is processed in milk. The milk acts antagonistically on the sharp effects (teekshna guna) of lashuna.<ref>Shobha Hiremath, G. (2000). A textbook of bhaishjya kalpana. Panchavidha Kalpana (pp. 110). Bengaluru, India: IBH Prakashana.</ref></div>

<div style='text-align:justify;'>The action of aushadha may either increase or decrease when used in combination with other aushadha. It may show a synergistic effect with combined positive interactions with other ingredients. Their combined effect is greater than the sum of the effects seen when each aushadha is given alone. A synergism can be observed in the combination of ''Momordica charantia'' (Bitter guard) and conventional hypoglycaemic drugs. ''Momordica charantia''  extract when clinically co-administered with 50% of the full clinical  doses  of  allopathic  or  conventional drugs,  metformin  and  glibenclamide,  greater hypoglycemic  (decreased  serum  glucose)  effect  was  observed  in  patients  as  compared to  full clinical doses of metformin or glibenclamide alone thereby exhibiting additive and synergy effects.</br>On the contrary, the aushadha may also show an antagonistic effect in which one aushadha decreases or nullifies the action of other aushadha. For example, in the formulation lashuna ksheerapaka, lashuna (Allium sativum) is processed in milk. The milk acts antagonistically on the sharp effects (teekshna [[Guna|guna]]) of [[Lashuna|lashuna]].<ref>Shobha Hiremath, G. (2000). A textbook of bhaishjya kalpana. Panchavidha Kalpana (pp. 110). Bengaluru, India: IBH Prakashana.</ref></div>

== Importance of concept ==

== Importance of concept ==