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Line 60: + + − [[Dhatu]]s are the structural and functional units that act as [[dosha]] and [[mala]] seats. The functioning of dhatvagni (dhatvagnipaaka) includes overall nourishment and development of the body structures. Dhatvagnipaaka refers to the sequential changes undergone by the essence of food through the medium of seven dhatvagni entities. −
→Physiology of dhatvagni
==Physiology of dhatvagni==
==Physiology of dhatvagni==
[[Dhatu]]s are the structural and functional units that act as [[dosha]] and [[mala]] seats. The functioning of dhatvagni (dhatvagnipaaka) includes overall nourishment and development of the body structures. Dhatvagnipaaka refers to the sequential changes undergone by the essence of food through the medium of seven dhatvagni entities.
[[File: Fig_1_Datu_agni.JPG|500px|'''Figure 1: Action of different agnis on their respective dhatus and their products '''|thumb]]
[[File: Fig_1_Datu_agni.JPG|500px|'''Figure 1: Action of different agnis on their respective dhatus and their products '''|thumb]]
[[File: Fig_2_Datu_agni.JPG|500px|'''Figure 2: Dhatvagnipaka (intermediate metabolism)- Synthesis of constituents of sthayi (poshya) dhatu '''|thumb]]
[[File: Fig_2_Datu_agni.JPG|500px|'''Figure 2: Dhatvagnipaka (intermediate metabolism)- Synthesis of constituents of sthayi (poshya) dhatu '''|thumb]]
The seven dhatvagni act upon the respective [[dhatu]] by which each [[dhatu]] is metabolized into two parts i.e., essence (prasada bhaga) and by-products (mala bhaga). [Chakrapani on Cha.Sa.[[Chikitsa Sthana]] 15/15] [[Dhatu]] is metabolized by their inherent heat (ushma) or dhatvagni (transforming enzymes in the tissue elements). The nourishing fraction of [[dhatu]] (nutrient tissue elements) further nourishes the subsequent [[dhatu]] through their respective [[srotas]] (channels of circulation). For example, a poshaka [[rasa dhatu]] nourishes the [[rakta dhatu]].[Cha.Sa.[[Chikitsa Sthana]] 8/39] In this process, the formation of essence (prasad bhaga) can be correlated with anabolic pathways. The formation of metabolic wastes or by-products (kitta-paka) can be correlated with catabolic pathways.
The seven dhatvagni act upon the respective [[dhatu]] by which each [[dhatu]] is metabolized into two parts i.e., essence (prasada bhaga) and by-products (mala bhaga). [Chakrapani on Cha.Sa.[[Chikitsa Sthana]] 15/15] [[Dhatu]] is metabolized by their inherent heat (ushma) or dhatvagni (transforming enzymes in the tissue elements). The nourishing fraction of [[dhatu]] (nutrient tissue elements) further nourishes the subsequent [[dhatu]] through their respective [[srotas]] (channels of circulation). For example, a poshaka [[rasa dhatu]] nourishes the [[rakta dhatu]].[Cha.Sa.[[Chikitsa Sthana]] 8/39] In this process, the formation of essence (prasad bhaga) can be correlated with anabolic pathways. The formation of metabolic wastes or by-products (kitta-paka) can be correlated with catabolic pathways.