Changes

Kleda can lead to altered fluid distribution in body. It is a complication of lowered metabolism at cell level (dhatu agnimandya). The altered states include relative over hydration or cell dehydration, abnormal fluid regulation, and normal adaptation to hyperosmotic stress. These states could have different implications in obesity prevention and treatment. Therefore, kleda is an essential factor in treating obesity or any metabolic disorder.

Kleda can lead to altered fluid distribution in body. It is a complication of lowered metabolism at cell level (dhatu agnimandya). The altered states include relative over hydration or cell dehydration, abnormal fluid regulation, and normal adaptation to hyperosmotic stress. These states could have different implications in obesity prevention and treatment. Therefore, kleda is an essential factor in treating obesity or any metabolic disorder.

===Role of muscle tissue ([[mamsa dhatu]])===

====Role of muscle tissue ([[mamsa dhatu]])====

Muscle tissue ([[mamsa dhatu]]) is one of the vitiated factors ([[dushya]]) in obstinate urinary disorders including diabetes mellitus (prameha). The sequence of the pathology of prameha points to vitiation of adipose tissue ([[meda dhatu]])at first. This [[meda dhatu]] infiltrates muscle tissue ([[mamsa dhatu]]). [[Mamsa dhatu]] is vitiated in prameha due to excess [[kapha]] and obstruction of body channels (avaranajanaya prameha). This indicates that smooth muscles and skeletal muscles are affected in prameha. Fatty infiltration in skeletal muscles and oxidized lipid deposition in the endothelial layer of arteries is the primary pathology observed in muscles. This pathology develops strong insulin resistance at the skeletal muscle level. This creates more hunger pains and increases food intake. This pathology can be compared with hyperfunctioning of [[agni]] due to trapped [[vata][[dosha]] as mentioned earlier.

Muscle tissue ([[mamsa dhatu]]) is one of the vitiated factors ([[dushya]]) in obstinate urinary disorders including diabetes mellitus (prameha). The sequence of the pathology of prameha points to vitiation of adipose tissue ([[meda dhatu]])at first. This [[meda dhatu]] infiltrates muscle tissue ([[mamsa dhatu]]). [[Mamsa dhatu]] is vitiated in prameha due to excess [[kapha]] and obstruction of body channels (avaranajanaya prameha). This indicates that smooth muscles and skeletal muscles are affected in prameha. Fatty infiltration in skeletal muscles and oxidized lipid deposition in the endothelial layer of arteries is the primary pathology observed in muscles. This pathology develops strong insulin resistance at the skeletal muscle level. This creates more hunger pains and increases food intake. This pathology can be compared with hyperfunctioning of [[agni]] due to trapped [[vata][[dosha]] as mentioned earlier.