Changes

[[File:Obesity_patogenesis.JPG|500px|'''Image 2: Pathogenesis of Obesity'''|thumb]]  

[[File:Obesity_patogenesis.JPG|500px|'''Image 2: Pathogenesis of Obesity'''|thumb]]  

===Role of body fluids (kleda)===

====Role of body fluids (kleda)====

Kleda is a physiological factor responsible for moisture.[Cha.Sa. Sthana??] It is essential to properly digest food and get food assimilated into body tissues ([[dhatu]]). It is one among the factors which are responsible for the transformation of food (aharaparinamakara bhava).[Cha.Sa. [[Sharira Sthana]] 6/14] In the normal state, it eases digestion. It is retained by sweat to moisten the skin. Excess of it is excreted through urine. When vitiated, it induces laxity, oozing or dampness in body tissues and thereby decline in their functions. It liquefies the [[dhatu]] quantitatively. It is closely associated with vitiated [[kapha]][[dosha]] and adipose tissue ([[meda dhatu]]).  It can result in rotting, putrification and decomposition of body tissues. Kleda can be ascribed as an inflammation-creating factor at cellular level in body tissues. In metabolic syndrome, it creates inflammation of adipose tissue ([[meda dhatu]]). Excess kleda disturbs the microenvironment of the tissues.  Vitiated kleda can result in cellular and tissue laxity, low-grade inflammation, mitochondrial dysfunction, or endoplasmic reticulum stress.   

Kleda is a physiological factor responsible for moisture.[Cha.Sa. Sthana??] It is essential to properly digest food and get food assimilated into body tissues ([[dhatu]]). It is one among the factors which are responsible for the transformation of food (aharaparinamakara bhava).[Cha.Sa. [[Sharira Sthana]] 6/14] In the normal state, it eases digestion. It is retained by sweat to moisten the skin. Excess of it is excreted through urine. When vitiated, it induces laxity, oozing or dampness in body tissues and thereby decline in their functions. It liquefies the [[dhatu]] quantitatively. It is closely associated with vitiated [[kapha]][[dosha]] and adipose tissue ([[meda dhatu]]).  It can result in rotting, putrification and decomposition of body tissues. Kleda can be ascribed as an inflammation-creating factor at cellular level in body tissues. In metabolic syndrome, it creates inflammation of adipose tissue ([[meda dhatu]]). Excess kleda disturbs the microenvironment of the tissues.  Vitiated kleda can result in cellular and tissue laxity, low-grade inflammation, mitochondrial dysfunction, or endoplasmic reticulum stress.