The bone tissue regulates acid-base balance, stores calcium, and fat cells. It acts as an endocrine organ by controlling the phosphate metabolism. It release fibroblast growth factor – 23 (FGF-23), which acts on kidneys to reduce phosphate reabsorption. The bone cells also release a hormone called osteocalcin. This contributes to the regulation of blood sugar (glucose) and fat deposition. Osteocalcin increases both insulin secretion and sensitivity, in addition to boosting the number of insulin-producing cells and reducing stores of fat. | The bone tissue regulates acid-base balance, stores calcium, and fat cells. It acts as an endocrine organ by controlling the phosphate metabolism. It release fibroblast growth factor – 23 (FGF-23), which acts on kidneys to reduce phosphate reabsorption. The bone cells also release a hormone called osteocalcin. This contributes to the regulation of blood sugar (glucose) and fat deposition. Osteocalcin increases both insulin secretion and sensitivity, in addition to boosting the number of insulin-producing cells and reducing stores of fat. |