Changes

==== Chart 3: Diagrammatic representation of importance of ''Agni'' ====

==== Chart 3: Diagrammatic representation of importance of ''Agni'' ====

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Determination of psychosomatic constitution as well as disease susceptibility of an individual in population through genetic trait is known as ''prakriti''. ''Prakriti'' is a broad term encompasses all the three genotype, phenotype as well as endophenotype.  The concept of prakriti in Ayurveda is related to the bio-characteristic of an individual in healthy state and its vulnerability for particular diseases. According to Ayurveda, ''prakriti'' of an individual once determined at the time of fertilization remains unchanged throughout life though it is well influenced by environment. Role of environment in determination of ''prakriti'' during prenatal period is as important as postnatal period. Reviewing the human embryology, it can be postulated that the three primitive germinal layers namely ectoderm, mesoderm and endoderm can be correlated with ''vatika, paittika'' and ''kaphaja'' trait. According to Ayurveda at the time of fertilization the ''doshika prakriti'' is determined by the ''doshika'' predominance of ''shukra'' (sperm) and ''shonita'' (ovum) that represent the fastidious genetic alignment of chromosomes in sperm and ovum and decide the genetic trait of zygote. Robust research is being conducted to study the link between ''prakriti'' and genes.

Determination of psychosomatic constitution as well as disease susceptibility of an individual in population through genetic trait is known as ''prakriti''. ''Prakriti'' is a broad term encompasses all the three genotype, phenotype as well as endophenotype.  The concept of prakriti in [[Ayurveda]] is related to the bio-characteristic of an individual in healthy state and its vulnerability for particular diseases. According to [[Ayurveda]], ''prakriti'' of an individual once determined at the time of fertilization remains unchanged throughout life though it is well influenced by environment. Role of environment in determination of ''prakriti'' during prenatal period is as important as postnatal period. Reviewing the human embryology, it can be postulated that the three primitive germinal layers namely ectoderm, mesoderm and endoderm can be correlated with ''vatika, paittika'' and ''kaphaja'' trait. According to [[Ayurveda]] at the time of fertilization the ''doshika prakriti'' is determined by the ''doshika'' predominance of ''shukra'' (sperm) and ''shonita'' (ovum) that represent the fastidious genetic alignment of chromosomes in sperm and ovum and decide the genetic trait of zygote. Robust research is being conducted to study the link between ''prakriti'' and genes.

In [[Nidana Sthana]] Chapter 4 ([[Prameha Nidana]]), Acharya says that the development of disease is multifactorial and it depends upon both the virulence of pathogens (''nidana'') as well as host response (''dushya''). Response of the host can be quantified by using ''prakriti'' as a parameter. [13]

In [[Nidana Sthana]] Chapter 4 ([[Prameha Nidana]]), Acharya says that the development of disease is multifactorial and it depends upon both the virulence of pathogens (''nidana'') as well as host response (''dushya''). Response of the host can be quantified by using ''prakriti'' as a parameter. [13]

#Kajaria Divya, Tripathi J.S, Tiwari S.K. Clinical Application of Concept of Agni. Asian Journal of Pharmaceutical Research. 2014; 4(1):1-5.

#Kajaria Divya, Tripathi J.S, Tiwari S.K. Clinical Application of Concept of Agni. Asian Journal of Pharmaceutical Research. 2014; 4(1):1-5.

#Kajaria Divya, Tripathi J.S, Tiwari S.K. Exploring Novel Concept of Agni and its Clinical Relevance. Alternative & Intregrative Medicine.2013; 2(8):1-5.

#Kajaria Divya, Tripathi J.S, Tiwari S.K. Exploring Novel Concept of Agni and its Clinical Relevance. Alternative & Intregrative Medicine.2013; 2(8):1-5.

#Patwardhan, B., and Mashelkar, R. A. (2009) Traditional medicine-inspired approaches to drug discovery: can Ayurveda show the way forward? Drug Discovery Today 14 (15-16), 804–11.

#Patwardhan, B., and Mashelkar, R. A. (2009) Traditional medicine-inspired approaches to drug discovery: can [[Ayurveda]] show the way forward? Drug Discovery Today 14 (15-16), 804–11.

#Bhushan, P., Kalpana, J., and Arvind, C. (2005) Classification of human population based on HLA gene polymorphism and the concept of Prakriti in Ayurveda. J. Altern. Complement. Med. 11 (2), 349–53.

#Bhushan, P., Kalpana, J., and Arvind, C. (2005) Classification of human population based on HLA gene polymorphism and the concept of Prakriti in [[Ayurveda]]. J. Altern. Complement. Med. 11 (2), 349–53.

#Prasher, B., Negi, S., Aggarwal, S., Mandal, A. K., Sethi, T. P.,Deshmukh, S. R., Purohit, S. G., Sengupta, S., Khanna, S., Mohammad, F., Garg, G., Brahmachari, S. K., Indian Genome Variation Consortium, Mukerji, M. (2008) Whole genome expression and biochemical correlates of extreme constitutional types de!ned in Ayurveda. J. Transl. Med.6, 48.

#Prasher, B., Negi, S., Aggarwal, S., Mandal, A. K., Sethi, T. P.,Deshmukh, S. R., Purohit, S. G., Sengupta, S., Khanna, S., Mohammad, F., Garg, G., Brahmachari, S. K., Indian Genome Variation Consortium, Mukerji, M. (2008) Whole genome expression and biochemical correlates of extreme constitutional types de!ned in [[Ayurveda]]. J. Transl. Med.6, 48.

#Aggarwal, S., Negi, S., Jha, P., Singh, P. K., Stobdan, T., Pasha,M. A., Ghosh, S., Agrawal, A., Prasher, B., and Mukerji, M. (2010) EGLN1 involvement in high-altitude adaptation revealed through genetic analysis of extreme constitution types de!ned in Ayurveda. Proc.Natl. Acad. Sci. U.S.A. 107 (44), 18961–6.

#Aggarwal, S., Negi, S., Jha, P., Singh, P. K., Stobdan, T., Pasha,M. A., Ghosh, S., Agrawal, A., Prasher, B., and Mukerji, M. (2010) EGLN1 involvement in high-altitude adaptation revealed through genetic analysis of extreme constitution types de!ned in [[Ayurveda]]. Proc.Natl. Acad. Sci. U.S.A. 107 (44), 18961–6.

#Peng, Y., Yang, Z., Zhang, H., Cui, C., Qi, X., Luo, X., Tao, X.,Wu, T., Ouzhuluobu, B., Ciwangsangbu, D., Chen, H., Shi, H., and Su, B. (2011) Genetic variations in Tibetan populations and high-altitude adaptation at the Himalayas. Mol. Biol. Evol. 28 (2), 1075–81.

#Peng, Y., Yang, Z., Zhang, H., Cui, C., Qi, X., Luo, X., Tao, X.,Wu, T., Ouzhuluobu, B., Ciwangsangbu, D., Chen, H., Shi, H., and Su, B. (2011) Genetic variations in Tibetan populations and high-altitude adaptation at the Himalayas. Mol. Biol. Evol. 28 (2), 1075–81.

#Xu, S., Li, S., Yang, Y., Tan, J., Lou, H., Jin, W., Yang, L., Pan, X.,Wang, J., Shen, Y., Wu, B., Wang, H., and Jin, L. (2011) A genome-wide search for signals of high-altitude adaptation in Tibetans. Mol. Biol. Evol.28 (2), 1003–11.

#Xu, S., Li, S., Yang, Y., Tan, J., Lou, H., Jin, W., Yang, L., Pan, X.,Wang, J., Shen, Y., Wu, B., Wang, H., and Jin, L. (2011) A genome-wide search for signals of high-altitude adaptation in Tibetans. Mol. Biol. Evol.28 (2), 1003–11.