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The jatharagni essentially nourishes the respective [[dhatu]] in the form of dhatvagni residing in each of the [[dhatu]]. [A.H.Sutra Sthana 11/34]<ref name= Hridaya > Vagbhata. Ashtanga Hridayam. Edited by Harishastri Paradkar Vaidya. 1st ed. Varanasi: Krishnadas Academy;2000.</ref> The dhatvagni is responsible for the increase (vriddhi)/ decrease (kshaya) of the representative [[dhatu]]. The hypo functioning (saada) of the dhatvagni leads to the increase in the respective [[dhatu]]. While hyper functioning (atideepti) leads to diminished production (kshaya) of the [[dhatu]]. Thus, every [[dhatu]]'s metabolism depends on the functions of the dhatvagni, preceding and subsequent [[dhatu]].
The jatharagni essentially nourishes the respective [[dhatu]] in the form of dhatvagni residing in each of the [[dhatu]]. [A.H.Sutra Sthana 11/34]<ref name= Hridaya > Vagbhata. Ashtanga Hridayam. Edited by Harishastri Paradkar Vaidya. 1st ed. Varanasi: Krishnadas Academy;2000.</ref> The dhatvagni is responsible for the increase (vriddhi)/ decrease (kshaya) of the representative [[dhatu]]. The hypo functioning (saada) of the dhatvagni leads to the increase in the respective [[dhatu]]. While hyper functioning (atideepti) leads to diminished production (kshaya) of the [[dhatu]]. Thus, every [[dhatu]]'s metabolism depends on the functions of the dhatvagni, preceding and subsequent [[dhatu]].
[[File: Fig_1_Datu_agni.JPG|500px|'''Figure 1: Action of different agnis on their respective dhatus and their products '''|thumb]]
[[File: Fig_2_Datu_agni.JPG|500px|'''Figure 2: Dhatvagnipaka (intermediate metabolism)- Synthesis of constituents of sthayi (poshya) dhatu '''|thumb]]
Interaction of [[dosha]]-[[dhatu]] (samurchhana) is the basis of pathogenesis. The state of [[agni]] should be considered in the pathogenesis. Any derangement of [[dosha]], if not corrected properly, progresses deeper into the [[dhatu]]s and becomes more challenging to correct. Progressive pathogenesis in any [[dhatu]] should be controlled by specific measures, otherwise it affects other sequential [[dhatu]]s. [Su.Sa.Sutra Sthana 21] So the role of dhatvagni is very important for metabolic disorders like dyslilipdemia (medoroga), obstinate urinary disease including diabetes ([[prameha]]), obesity (sthaulya). [[Agni]] and ultimately the dhatvagni are the basic concepts that are important to rule out the cause and treatment of any disease. The crucial aspects of concept of dhatvagni can be summarized as shown in Figure 1
This concept can also be depicted through the flowchart as given in Figure 2 [Dalhana on Su.Sa.Sutra Sthana 14/10]<ref name=Susruta/>
==Importance of concept of dhatvagni in physiology==
Dhatvagni, in general, represents the process of tissue metabolism and assimilation. Different types of wholesome foods ingested in the form of eatables, drinkables, lickables and masticables stimulate digestion (antaragni). They are further digested by respective bhutagni (specific digestion per primary constituent or element). In due course of time, food gets transformed into different [[dhatu]] in the presence of dhatvagni (tissue-specific digestion and metabolism) [A.H.Sharira Sthana 3/62]<ref name=Hridaya/> and [[vata]] (vyanavayu) by the process of dhatvagnipaka. [A.S.Sharira Sthana 6]<ref name=Sangraha/> It nourishes the tissues through channels of circulation without interruption and produces plumpness, strength, complexion, health, and longevity. The tissues are sustained by getting fed by various nourishing factors (poshaka dhatu). Thus, it plays a vital role in maintaining the digestive physiology and assimilation in the body. [Cha.Sa.[[Sutra Sthana]] 28/3] Therefore, the whole genesis, metabolism, functioning and elimination of [[dhatu]] are dependent on this process of dhatvagnipaaka. [Cha.Sa.[[Sutra Sthana]] 28/3] Hence, it is the basis of the ksheeradadhinyaya (law of complete transformation of one substance to other like milk into curd) and kedarikulyanyaya (sequential transformation of tissues just like canals in a farm). This depicts the [[dhatu]] metabolism. [Chakrapani on Cha.Sa.[[Chikitsa Sthana]] 15/16] Thus, the systematic nourishment of [[dhatu]] (dhatusnehaparampara) is maintained through dhatvagni. [Cha.Sa.[[Chikitsa Sthana]] 15/19][Arunadatta on A.H.Sharira Sthana 3/70]<ref name=Hridaya/>
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