In later stage, it spreads all over and systemic involvement is seen. [A. Hr. [[Nidana Sthana]] 16/7]<ref name=Hridaya/> In advanced stages, severe deformity of the joints is seen. When the skin is involved, it shows cutaneous manifestations. When blood vessels are involved, it can cause damage to the blood vessels, extreme pain, and even death. | In later stage, it spreads all over and systemic involvement is seen. [A. Hr. [[Nidana Sthana]] 16/7]<ref name=Hridaya/> In advanced stages, severe deformity of the joints is seen. When the skin is involved, it shows cutaneous manifestations. When blood vessels are involved, it can cause damage to the blood vessels, extreme pain, and even death. |