Changes

It is important to know the good things to be followed and avoid bad things by one for longevity. It is advised to gradually give up addictions and adopt wholesome habits increasingly. The protocol advised is, on the first day one should give up a quarter of the unwholesome practice (still maintaining three-fourths of it,) and correspondingly adopt a quarter of wholesome. On the second day, half of the unwholesome practice should be given up and half of the wholesome one should be adopted; this is to be continued for the third day also. On the fourth day, three-fourths of the unwholesome practice should be given up and three-fourths of the wholesome one should be adopted. This process should be continued on the fifth and sixth day also. The process of giving up of the unwholesome practice and adoption of the wholesome practice is completed fully on the seventh day.  

It is important to know the good things to be followed and avoid bad things by one for longevity. It is advised to gradually give up addictions and adopt wholesome habits increasingly. The protocol advised is, on the first day one should give up a quarter of the unwholesome practice (still maintaining three-fourths of it,) and correspondingly adopt a quarter of wholesome. On the second day, half of the unwholesome practice should be given up and half of the wholesome one should be adopted; this is to be continued for the third day also. On the fourth day, three-fourths of the unwholesome practice should be given up and three-fourths of the wholesome one should be adopted. This process should be continued on the fifth and sixth day also. The process of giving up of the unwholesome practice and adoption of the wholesome practice is completed fully on the seventh day.  

=== [[Dosha]] dominant [[prakriti]], susceptibility to disease and specific diet for prevention of diseases ===

=== [[Dosha]] dominant [[prakriti]], susceptibility to disease and specific diet for prevention of [[diseases]] ===

 

====Importance====

====Importance====

The crux of prevention of diseases is maintaining a balance of [[dosha]] from time of conception. If the [[dosha]] are in equilibrium within the body of an individual, the person does not suffer from diseases. The imbalance including predominance of a single [[dosha]] in [[prakriti]] makes him/her susceptible to diseases. The balance of [[dosha]] can be maintained through habitual intake of diet of all rasas and following those regimens with opposite properties of dominant [[dosha]] in [[prakriti]]. Therefore, to know the predominant [[dosha]] in one’s constitution is very important for prescribing suitable diet and lifestyle regimen in prevention and management of diseases. The suitable dietary regimen for each [[dosha]] [[prakriti]] is described in detail in the eighth chapter of [[Vimana Sthana]].  

The crux of prevention of diseases is maintaining a balance of [[dosha]] from time of conception. If the [[dosha]] are in equilibrium within the body of an individual, the person does not suffer from diseases. The imbalance including predominance of a single [[dosha]] in [[prakriti]] makes him/her susceptible to diseases. The balance of [[dosha]] can be maintained through habitual intake of diet of all rasas and following those regimens with opposite properties of dominant [[dosha]] in [[prakriti]]. Therefore, to know the predominant [[dosha]] in one’s constitution is very important for prescribing suitable diet and lifestyle regimen in prevention and management of diseases. The suitable dietary regimen for each [[dosha]] [[prakriti]] is described in detail in the eighth chapter of [[Vimana Sthana]].  

====Phenotypic co-relation of [[prakriti]]====

====Phenotypic co-relation of [[prakriti]]====

Every individual is different from another and hence should be considered as a separate entity.<ref> Valiathan, M. S.,The Legacy of Caraka, Orient Longman, Chennai, 2003.</ref>  The three broad classes of ‘prakriti’  are based on certain physical, physiological and psychological characters.<ref> Swoboda, R. E., Prakruti: Ayurvedic Constitution, Motilal Banarasidas Publishers, Varanasi, 1996.</ref> The scientists suggest phenotypic classification of India’s traditional medicine has a genetic basis; and its Prakriti-based practice in vogue for many centuries resonates with personalized medicine. <ref name= "Govindraj P Genome"> Govindaraj P, Nizamuddin S, Sharath A, et al. Genome-wide analysis correlates Ayurveda Prakriti. Nat Publ Gr.:1-12. doi:10.1038/srep15786</ref>. Thus [[prakriti]] concept is independent of racial, ethnic or geographical considerations and may provide appropriate means of classifying phenotypes to be considered collectively for genotyping.  In a study, the researchers postulated that human phenome based on prakriti, namely [[kapha]], [[pitta]] and [[vata]] have the genetic connotation that could help classifying human population based on broad phenotype clusters. Accordingly, HLA DR alleles among various [[prakriti]] classes and demonstrated significant associations were analysed. <ref>Patwardhan, B., Joshi, K. and Chopra, A., Classification of human population based on HLA gene polymorphism and the concept of Prakriti in Ayurveda.J. Altern. Complement. Med., 2005, 11, 349– 353. </ref>  The concept of constitutional uniqueness of human individuals and personalized prescription of diet and drugs is special feature of [[Ayurveda]]. This has similarities with the pharmacogenomics and customized medicine.<ref>Patwardhan, B.,Ayurveda: The 'Designer' medicine: A review of ethnopharmacology and bioprospecting research. Indian Drugs, 2000, 37, 213–227.</ref>   

Every individual is different from another and hence should be considered as a separate entity.<ref> Valiathan, M. S.,The Legacy of Caraka, Orient Longman, Chennai, 2003.</ref>  The three broad classes of ‘prakriti’  are based on certain physical, physiological and psychological characters.<ref> Swoboda, R. E., Prakruti: Ayurvedic Constitution, Motilal Banarasidas Publishers, Varanasi, 1996.</ref> The scientists suggest phenotypic classification of India’s traditional medicine has a genetic basis; and its Prakriti-based practice in vogue for many centuries resonates with personalized medicine. <ref name= "Govindraj P Genome"> Govindaraj P, Nizamuddin S, Sharath A, et al. Genome-wide analysis correlates Ayurveda Prakriti. Nat Publ Gr.:1-12. doi:10.1038/srep15786</ref>. Thus [[prakriti]] concept is independent of racial, ethnic or geographical considerations and may provide appropriate means of classifying phenotypes to be considered collectively for genotyping.  In a study, the researchers postulated that human phenome based on prakriti, namely [[kapha]], [[pitta]] and [[vata]] have the genetic connotation that could help classifying human population based on broad phenotype clusters. Accordingly, HLA DR alleles among various [[prakriti]] classes and demonstrated significant associations were analysed. <ref>Patwardhan, B., Joshi, K. and Chopra, A., Classification of human population based on HLA gene polymorphism and the concept of Prakriti in Ayurveda.J. Altern. Complement. Med., 2005, 11, 349– 353. </ref>  The concept of constitutional uniqueness of human individuals and personalized prescription of diet and drugs is special feature of [[Ayurveda]]. This has similarities with the pharmacogenomics and customized medicine.<ref>Patwardhan, B.,Ayurveda: The 'Designer' medicine: A review of ethnopharmacology and bioprospecting research. Indian Drugs, 2000, 37, 213–227.</ref>   

In a study on  genome-wide SNP (single nucleotide polymorphism) analysis of 262 well-classified male individuals (after screening 3416 subjects) belonging to three [[Prakriti]] ([[Vata]], [[Pitta]], [[Kapha]]), it is observed that PGM1 correlates with phenotype of Pitta as described in the ancient text of Charaka Samhita.<ref name= "Govindraj P Genome" />

In a study on  genome-wide SNP (single nucleotide polymorphism) analysis of 262 well-classified male individuals (after screening 3416 subjects) belonging to three [[Prakriti]] ([[Vata]], [[Pitta]], [[Kapha]]), it is observed that PGM1 correlates with phenotype of Pitta as described in the ancient text of Charaka Samhita.<ref name= "Govindraj P Genome" />

#Andhare RV:2003: Vibhinna deha prakriti ke vyaktiyon mein Dehoshma [body temperature] par kala tatha vayanusar vyayama [exercise] ka prabhava : Ek adhyayana

#Andhare RV:2003: Vibhinna deha prakriti ke vyaktiyon mein Dehoshma [body temperature] par kala tatha vayanusar vyayama [exercise] ka prabhava : Ek adhyayana

==References==

==References==