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→Rationale for mixing sequence of basti
*''Kashaya'' for ''samatam vrajet'' (mixture becomes homogenous)
*''Kashaya'' for ''samatam vrajet'' (mixture becomes homogenous)
*''Mutra''- increases the action & potency ''basti''.<ref>Kashyapa, Kashyapa Samhita, Siddhisthana, chapter 1, Chaukhamba Sanskrit Sansthan, Varanasi, 1990</ref>
*''Mutra''- increases the action & potency ''basti''.<ref>Kashyapa, Kashyapa Samhita, Siddhisthana, chapter 1, Chaukhamba Sanskrit Sansthan, Varanasi, 1990</ref>
This is very important concept for enhancing bio availability of rectally administered drugs. Honey, rock salt (saindhava), unctuous material (sneha) and paste of medicines (kalka) are found commonly in all the therapeutic enema (basti). They act as the vehicle to enhance the effect of drugs administered rectally and also has specific action depending upon their own properties. Actually basti is a homogeneous oil in water type of emulsion somewhat similar to milk which is best example of natural emulsion. Studies on certain drugs suggest significant bio-availability enhancement relative to their aqueous formulations.<ref>Constantinides, P.P., Scalart, J., Lancaster, C. et al. Formulation and Intestinal Absorption Enhancement Evaluation of Water-in-Oil Microemulsions Incorporating Medium-Chain Glycerides. Pharm Res 11, 1385–1390 (1994)</ref> This effect is attributed to the reduced droplet size, improved drug solubility, protection against enzymatic hydrolysis and potential for enhance absorption afforded by surfactant induced membrane fluidity and thus permeability changes.<ref>E. C. Swenson and W. J. Curatolo. Intestinal permeability enhancement for proteins, peptides and other polar drugs: mechanisms and potential toxicity. Adv. Drug Deliv. Rev. 8: 39–92, (1992).</ref> In case of basti combination of honey and rock salt mainly acts as surfactant. Classical texts also gives mode of action of this combination as to disintegrate kapha dosha and detach it from its site (Kaphachedana-Kaphavilayana) which signifies the changes in permeability.
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