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The bone tissue regulates acid-base balance, stores calcium, and fat cells.  It acts as an endocrine organ by controlling the phosphate metabolism. It release fibroblast growth factor – 23 (FGF-23), which acts on kidneys to reduce phosphate reabsorption. The bone cells also release a hormone called osteocalcin. This contributes to the regulation of blood sugar (glucose) and fat deposition. Osteocalcin increases both insulin secretion and sensitivity, in addition to boosting the number of insulin-producing cells and reducing stores of fat.

The bone tissue regulates acid-base balance, stores calcium, and fat cells.  It acts as an endocrine organ by controlling the phosphate metabolism. It release fibroblast growth factor – 23 (FGF-23), which acts on kidneys to reduce phosphate reabsorption. The bone cells also release a hormone called osteocalcin. This contributes to the regulation of blood sugar (glucose) and fat deposition. Osteocalcin increases both insulin secretion and sensitivity, in addition to boosting the number of insulin-producing cells and reducing stores of fat.<ref> Lee, Na Kyung; et al. (10 August 2007). "Endocrine Regulation of Energy Metabolism by the Skeleton". Cell. 130 (3): 456–469. doi:10.1016/j.cell.2007.05.047. PMC 2013746. PMID 17693256</ref>

==Importance in diagnosis==

==Importance in diagnosis==