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| ==== I. Radiological investigation ==== | | ==== I. Radiological investigation ==== |
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− | ===== Scanning electron microscopy (SEM) =====
| + | '''1. Scanning electron microscopy (SEM)''' |
| | | |
| * '''Purpose''': | | * '''Purpose''': |
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| *RBC spacing within the muscle tissue – 3D distance mapping | | *RBC spacing within the muscle tissue – 3D distance mapping |
| | | |
− | * Tissue oxygenation | + | *Tissue oxygenation |
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− | ===== Muscle ultrasound =====
| + | '''2. Muscle ultrasound''' |
| | | |
| * '''Purpose''' : | | * '''Purpose''' : |
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| * Non-invasive technique for assessment of muscular dystrophies & skeletal muscle disorders in the pediatric population. | | * Non-invasive technique for assessment of muscular dystrophies & skeletal muscle disorders in the pediatric population. |
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− | ==== Culture tests ==== | + | ==== II. Culture tests ==== |
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| * Muscle mass biopsy | | * Muscle mass biopsy |
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− | ==== Electro-diagnostic techniques==== | + | ==== III. Electro-diagnostic techniques==== |
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| '''1. Electromyography (EMG)''' | | '''1. Electromyography (EMG)''' |
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| *Evaluation of deep muscles inherited myopathies | | *Evaluation of deep muscles inherited myopathies |
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− | * It also provides information about the best sites of muscle biopsy. | + | *It also provides information about the best sites of muscle biopsy. |
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− | ==== Hematological & Serological investigation ==== | + | ==== IV. Hematological & Serological investigation ==== |
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| #Creatine Kinase (CK) or Creatine Phosphokinase (CPK)–Myopathies | | #Creatine Kinase (CK) or Creatine Phosphokinase (CPK)–Myopathies |
− | | + | #Aldolase – Identifies the weakness of the muscle. |
− | #Aldolase – Identifies the weakness of muscle. | |
− | | |
| #Erythrocyte sedimentation rate (ESR) – Used to measure or assess inflammation of muscles. | | #Erythrocyte sedimentation rate (ESR) – Used to measure or assess inflammation of muscles. |
− |
| |
| #Antibody evaluation for specific diseases – Ex. Anti-Acetylcholine (Ach) antibodies & Anti-Muscle specific kinase (MUSK) antibodies in Myasthenia Gravis | | #Antibody evaluation for specific diseases – Ex. Anti-Acetylcholine (Ach) antibodies & Anti-Muscle specific kinase (MUSK) antibodies in Myasthenia Gravis |
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− | ==== Genetics ==== | + | ==== V. Genetics ==== |
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− | *'''Exome sequencing'''
| + | '''Exome sequencing''' |
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| '''Purpose:''' | | '''Purpose:''' |
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− | * Identification of genetic variations at base-pair resolution throughout the human genome which targets the proportion of DNA that codes proteins for capturing and sequencing. | + | * Identification of genetic variations at base-pair resolution throughout the human genome which targets the proportion of DNA that codes proteins for capturing and sequencing. |
| | | |
| === Pathological conditions === | | === Pathological conditions === |