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<big>'''Nidana Sthana Chapter 6. Diagnosis and etiopathogenesis of Progressive wasting disease'''</big>
<big>'''Abstract'''</big>
<div style="text-align:justify;">This chapter describes the basics of etiopathogenesis of progressive wasting disease termed as shosha roga and its culmination in rajayakshma vis-à-vis pulmonary tuberculosis. Shosha is characterized by severe depletion of tissues (also called phthisis) which could be a precursor of tuberculosis as known today which occurs due to tubercular infection, phthisis and immune-compromised state. Over exertion (sahasa), suppression of natural urges (vegavidharana), pre-existing emaciation (kshaya), and wrong dietary habits (vishamashana) are the four primary causes of shosha. These four basic factors lead to progressive loss of strength (including immunity), vitiating the three doshas and culminating in rajayakshma, a major organic disease that seems to be similar to various similar progressively wasting diseases presenting characteristically with signs and symptoms of Pulmonary Tuberculosis as seen today and has been described in great clinical and therapeutic detail in [[ Rajayakshma Chikitsa ]]. </div>
'''Keywords''': ''kshaya'', ''shosha'', ''yakshma'', ''sahasa'', ''visamashana'', ''Nidanarthakara Roga Vyadhiksamatva'', ''Ojakshaya'', chronic wasting diseases, Immune defense, ''Rasayana'', exertion, improper dietary habits, suppression of natural urges, depletion of tissue.
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{{Infobox
{{Infobox
|title = Shosha Nidana
|title = Shosha Nidana
}}
}}
=== Introduction ===
=== Introduction ===
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