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Various researches have proved the direct relation of seasonal variation on physiological and pathological changes in body:   

Various researches have proved the direct relation of seasonal variation on physiological and pathological changes in body:   

*Climate change has a profound effect on human health and well-being. The impact of climate change on human well-being goes beyond mortality; even birth rates and sperm counts appear to be affected by meteorological phenomenon.25,26,27

*Climate change has a profound effect on human health and well-being. The impact of climate change on human well-being goes beyond mortality; even birth rates and sperm counts appear to be affected by meteorological phenomenon.,<ref> Calot and Blayo, 1982 </ref> <ref> Tjoa et al, 1982 </ref> <ref> White and Hertz, 1985 </ref>

*Morbidity attributed to pneumonia, influenza, bronchitis, and probably many other illnesses are also weather-related.28

*Morbidity attributed to pneumonia, influenza, bronchitis, and probably many other illnesses are also weather-related.<ref>  White et al, 1985  </ref>

*Medical disorders such as bronchitis, peptic ulcer, adrenal ulcer, glaucoma, goiter, eczema, and herpes zoster are related to seasonal variations in temperature.29

*Medical disorders such as bronchitis, peptic ulcer, adrenal ulcer, glaucoma, goiter, eczema, and herpes zoster are related to seasonal variations in temperature.<ref> Tromp, 1963 </ref>

*A Canadian Climate Center study (1981) found that migraines were most likely to occur on days with falling pressure, rising humidity, high winds, and rapid temperature fluctuations.

*A Canadian Climate Center study (1981) found that migraines were most likely to occur on days with falling pressure, rising humidity, high winds, and rapid temperature fluctuations.

*Weather has an important influence on morbidity in the winter because cold, dry air leads to excessive dehydration of nasal passages and upper respiratory tract, and increased chance of microbial and viral infection. In general, total mortality is about 15% higher on an average winter day than on an average summer day, according to National Center for Health Statistics, 1978.

*Weather has an important influence on morbidity in the winter because cold, dry air leads to excessive dehydration of nasal passages and upper respiratory tract, and increased chance of microbial and viral infection. In general, total mortality is about 15% higher on an average winter day than on an average summer day, according to National Center for Health Statistics, 1978.

*Mortality rate during heat waves increases with age.30,31 The elderly seem to suffer from impaired physiological responses and often are unable to increase their cardiac output sufficiently during extremely hot weather.32

*Mortality rate during heat waves increases with age.<ref> Oechsli et al, 1970 </ref> <ref> Buechley et al, 1972 </ref> The elderly seem to suffer from impaired physiological responses and often are unable to increase their cardiac output sufficiently during extremely hot weather.<ref> Sprung C.L., 1979  </ref>

*It was noted that men who had taken bath in 15oC water for one-half hour over nine consecutive days before a trip to the Arctic showed less signs of cold-induced stress than non-treated men. It indicates that adaptation to cold temperatures can occur through repeated exposures. 33

*It was noted that men who had taken bath in 15oC water for one-half hour over nine consecutive days before a trip to the Arctic showed less signs of cold-induced stress than non-treated men. It indicates that adaptation to cold temperatures can occur through repeated exposures. <ref> Radomski and Boutelier, 1982 </ref>

*To a great extent, the seasonal changes in the immune system are controlled by changes in the levels of various hormones, particularly melatonin. Serum levels of melatonin were found to be highest in the winter months in both normal individuals and SLE patients.34 There is natural increase in ''bala'' (strength/immunity) of individuals during winter i.e. ''hemanta'' and ''shishira ritu''.

*To a great extent, the seasonal changes in the immune system are controlled by changes in the levels of various hormones, particularly melatonin. Serum levels of melatonin were found to be highest in the winter months in both normal individuals and SLE patients.<ref> Nelson et al., 2000 </ref> There is natural increase in ''bala'' (strength/immunity) of individuals during winter i.e. ''hemanta'' and ''shishira ritu''.

*Striking seasonal variations have been demonstrated in the plasma and saliva levels of the glucocorticoid, cortisol, which promotes carbohydrate metabolism. The lowest levels of cortisol were found in healthy individuals during spring and summer, while the highest levels were found during autumn and winter seasons.35

*Striking seasonal variations have been demonstrated in the plasma and saliva levels of the glucocorticoid, cortisol, which promotes carbohydrate metabolism. The lowest levels of cortisol were found in healthy individuals during spring and summer, while the highest levels were found during autumn and winter seasons.<ref>  Walker et al, 1997 </ref>

*''Agni'' (digestive power) of individuals is strong during winter i.e. ''hemanta'' and ''shishira ritu'', and weakest during ''grishma'' and ''varsha ritu.''

*''Agni'' (digestive power) of individuals is strong during winter i.e. ''hemanta'' and ''shishira ritu'', and weakest during ''grishma'' and ''varsha ritu.''

Rheumatic diseases vary in severity by season. The incidence of acute gouty attacks (an inflammatory arthritis) is highest in the spring season.36 Schlesinger N.et al. (2009) explained in his paper “Seasonal Variation of Rheumatic Diseases” that seasonal variation has been shown in a number of rheumatic diseases.37

Rheumatic diseases vary in severity by season. The incidence of acute gouty attacks (an inflammatory arthritis) is highest in the spring season.<ref> Schlesinger N et al., 1998 </ref> Schlesinger N.et al. (2009) explained in his paper “Seasonal Variation of Rheumatic Diseases” that seasonal variation has been shown in a number of rheumatic diseases.<ref> Schlesinger N et al, 2009 </ref>

*Coronary artery disease shows a winter peak and summer trough in incidence and mortality.38 Leo Sher also proposed that seasonal mood changes may contribute to the increased incidence and mortality of coronary artery disease in winter. Depression is associated with increased incidence, morbidity, and mortality of coronary artery disease.

*Coronary artery disease shows a winter peak and summer trough in incidence and mortality.<ref> Sher L., 2001 </ref> Leo Sher also proposed that seasonal mood changes may contribute to the increased incidence and mortality of coronary artery disease in winter. Depression is associated with increased incidence, morbidity, and mortality of coronary artery disease.

“Seasonal affective disorder” is a condition where depression in the winter and fall alternate with non-depressive periods in the spring and summer. The degree to which seasonal changes affect mood, energy, sleep, appetite, food preference, or the wish to socialize with other people has been called "seasonality." Recent studies have demonstrated that seasonal mood changes are related to the genetic factors. It means that people may have genetically‐determined sensitivity to seasons.     

“Seasonal affective disorder” is a condition where depression in the winter and fall alternate with non-depressive periods in the spring and summer. The degree to which seasonal changes affect mood, energy, sleep, appetite, food preference, or the wish to socialize with other people has been called "seasonality." Recent studies have demonstrated that seasonal mood changes are related to the genetic factors. It means that people may have genetically‐determined sensitivity to seasons.     

    

    

Jaiswal Rahul et al, 2011, in a clinical survey39 found a significant relation between seasonal variation and prevalence of some diseases viz. ''jwara'' (viral fever), ''amlapitta'' (acid peptic disorders), ''tamaka shvasa'' (bronchial asthma), ''pratishyaya'' (rhinitis) and ''sirashula'' (''pittaja sirashula'' and ''ardhavabhedaka'', migraine). They also observed that there is seasonal variation in the state of agni and bala strength) of the person, as stated by our ancient seers.  

Jaiswal Rahul et al, 2011, in a clinical survey<ref> Jaiswal Rahul et al, 2011 </ref> found a significant relation between seasonal variation and prevalence of some diseases viz. ''jwara'' (viral fever), ''amlapitta'' (acid peptic disorders), ''tamaka shvasa'' (bronchial asthma), ''pratishyaya'' (rhinitis) and ''sirashula'' (''pittaja sirashula'' and ''ardhavabhedaka'', migraine). They also observed that there is seasonal variation in the state of agni and bala strength) of the person, as stated by our ancient seers.  

*Nathani Neeru et al, 2013, in a clinical research40 found that maximum number of patients of ''tamaka shvasa'' (bronchial asthma) were registered in winter seasons (''hemanta'' and ''shishira''), ''vasanta'' and ''varsha''. These seasons were the predominant period of asthma attack in majority of cases. In maximum number of cases the attack of ''tamaka shvasa'' gets precipitated by intake of ''kapha'' and ''vata'' vitiating ''sheeta, guru, madhura'' and ''amla rasa'' predominant ''ahara'' like ice-cream, cold drink, cold water, fruit juices, curd, sweets, rice, pickle, salad with lemon etc. in all seasons. Out of 140 cases about half were observing ''ritucharya'' occasionally and less number of cases were found to adhere with ''ritucharya'' regularly. About two-third cases were bathing with cold water in winters and less number of cases were in the habit of daily head bath. This clinical study based on subjective parameters revealed that in patients of group A (treated with modern drug) and in group B (treated with modern drug along with observance of proper ''ritucharya'' of different seasons, highly significant improvement was observed in all symptoms. On intergroup comparison (Chi-square test) patients of group B showed significant rate of improvement in many symptoms like dyspnea, wheezing, cough, rhinorrhea, and frequency of attack and duration of attack. Inter group comparison between group A and B (unpaired t test) had shown statistically significant increase in FVC, FEV1 and PEFR of group B cases as compared to the patients of group A at different follow-ups. These finding suggest that ''ritucharya'' has a definite additive effect along with standard drug therapy in the treatment of ''tamaka shasa'' (bronchial asthma).

*Nathani Neeru et al, 2013, in a clinical research<ref> Nathani Neeru et al, 2013 </ref> found that maximum number of patients of ''tamaka shvasa'' (bronchial asthma) were registered in winter seasons (''hemanta'' and ''shishira''), ''vasanta'' and ''varsha''. These seasons were the predominant period of asthma attack in majority of cases. In maximum number of cases the attack of ''tamaka shvasa'' gets precipitated by intake of ''kapha'' and ''vata'' vitiating ''sheeta, guru, madhura'' and ''amla rasa'' predominant ''ahara'' like ice-cream, cold drink, cold water, fruit juices, curd, sweets, rice, pickle, salad with lemon etc. in all seasons. Out of 140 cases about half were observing ''ritucharya'' occasionally and less number of cases were found to adhere with ''ritucharya'' regularly. About two-third cases were bathing with cold water in winters and less number of cases were in the habit of daily head bath. This clinical study based on subjective parameters revealed that in patients of group A (treated with modern drug) and in group B (treated with modern drug along with observance of proper ''ritucharya'' of different seasons, highly significant improvement was observed in all symptoms. On intergroup comparison (Chi-square test) patients of group B showed significant rate of improvement in many symptoms like dyspnea, wheezing, cough, rhinorrhea, and frequency of attack and duration of attack. Inter group comparison between group A and B (unpaired t test) had shown statistically significant increase in FVC, FEV1 and PEFR of group B cases as compared to the patients of group A at different follow-ups. These finding suggest that ''ritucharya'' has a definite additive effect along with standard drug therapy in the treatment of ''tamaka shasa'' (bronchial asthma).

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