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→Excess heat
==== Excess heat ====
==== Excess heat ====
Among the lifestyle factors that lead down to aggravated ''pitta'' (''viharaja nidanas'') and raktapitta are excessive exercise/vyayama, and exposure to sunlight. Scientific evidence has now established that vigorous exercise appears to lower vitamin K levels and thus thin the blood. Sunlight increases the conversion of Vit D to Vit D3 in the skin; a recent clinical trial of a biologically active metabolite of Vit. D3 demonstrated an unanticipated reduction of thrombosis in cancer patients. Therefore, it appears that Vit D3 reduces blood clotting.
Among the lifestyle factors that lead down to aggravated ''pitta'' (''viharaja nidanas'') and ''raktapitta'' are excessive exercise(''vyayama''), and exposure to sunlight. Scientific evidence has now established that vigorous exercise appears to lower vitamin K levels and thus thin the blood. Sunlight increases the conversion of Vitamin D to Vitamin D3 in the skin; a recent clinical trial of a biologically active metabolite of Vitamin D3 demonstrated an unanticipated reduction of thrombosis in cancer patients. Therefore, it appears that Vitamin D3 reduces blood clotting.
==== Hereditary issues ====
Some bleeding disorders are known as hereditary or acquired through genetic transmission. Ayurveda seems to point to specific foods and habits that promote the manifestation of acquired bleeding disorders; one could propose an epigenetic mechanism to explain these disorders that have eventual onset. Bleeding disorders such as hemophilia that occur from birth, indeed all hereditary imperfections, are explained in ayurveda with the concept of beeja doṣha, or inheritance of papam through cycles of karma.
Some bleeding disorders are known as hereditary or acquired through genetic transmission. Ayurveda seems to point to specific foods and habits that promote the manifestation of acquired bleeding disorders; one could propose an epigenetic mechanism to explain these disorders that have eventual onset. Bleeding disorders such as hemophilia that occur from birth, indeed all hereditary imperfections, are explained in ayurveda with the concept of beeja doṣha, or inheritance of papam through cycles of karma.
Pathophysiology of Bleeding/Hemorrhagic Disorders in modern medicine
==== Pathophysiology of Bleeding/Hemorrhagic Disorders in modern medicine ====
Per biomedicine, bleeding disorders are a group of heterogenous conditions that occur when the blood cannot clot properly. In normal clotting, platelets stick together when prompted by a stimulus that invokes the clotting pathway to ultimately form a plug at the site of an injured blood vessel. Proteins in the blood (clotting factors) are activated when either a pathogen or an exposed cell wall signal rupture of the blood vessel. An interactive cascade then leads to the formation of a fibrin clot, which holds the platelets in place and allows repair to occur at the site of the injury while preventing blood from escaping the blood vessel. While too much clotting can create either a thrombus or embolus that may lead to a heart attack and stroke, the inability to form clots can be very dangerous as well, as excess bleeding will also interrupt the integrity of the vascular system.
Per biomedicine, bleeding disorders are a group of heterogenous conditions that occur when the blood cannot clot properly. In normal clotting, platelets stick together when prompted by a stimulus that invokes the clotting pathway to ultimately form a plug at the site of an injured blood vessel. Proteins in the blood (clotting factors) are activated when either a pathogen or an exposed cell wall signal rupture of the blood vessel. An interactive cascade then leads to the formation of a fibrin clot, which holds the platelets in place and allows repair to occur at the site of the injury while preventing blood from escaping the blood vessel. While too much clotting can create either a thrombus or embolus that may lead to a heart attack and stroke, the inability to form clots can be very dangerous as well, as excess bleeding will also interrupt the integrity of the vascular system.