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While describing "pancha-panchaka" principle of perception by five jnanaindriya, [Cha.Sa.[[Sutra Sthana]] 8/3] Charak mentions five [[indriya]] (senses), five [[indriya]] adhisthana(sense organs), five [[indriya]] dravya (specific matter which enable the senses to perceive), five artha (specific objects to be perceived by sense) and five [[indriya]]-buddhi(final sensation). The five [[indriya]] are the five senses and the five [[indriya]] adhisthana are the five external sites of senses for example eyes for vision and ears for hearing, but site of  the [[indriya]]-buddhi is not mentioned. In this regard, the following observations may be taken into consideration:

While describing "pancha-panchaka" principle of perception by five jnanaindriya, [Cha.Sa.[[Sutra Sthana]] 8/3] Charak mentions five [[indriya]] (senses), five [[indriya]] adhisthana(sense organs), five [[indriya]] dravya (specific matter which enable the senses to perceive), five artha (specific objects to be perceived by sense) and five [[indriya]]-buddhi(final sensation). The five [[indriya]] are the five senses and the five [[indriya]] adhisthana are the five external sites of senses for example eyes for vision and ears for hearing, but site of  the [[indriya]]-buddhi is not mentioned. In this regard, the following observations may be taken into consideration:

Charak mentions that ''prānavāhi srotāmsi'' of [[indriya]] are situated in the head and are connected with the body as sun is connected with its rays. Therefore, diseases such as ardita(facial paralysis), cheshta nasha(paralysis) and disorders of eye movement etc. are due to trauma to the head [Ca. Sa. [[Siddhi Sthana]] 9/4]. In this chapter, the physical location of all the [[indriya]] has been mentioned to be the head, hence on the basis of these observations, it can be concluded that the [[indriya]]-[[buddhi]] are also situated in head. "[[Indriya buddhi]]" is that vital part of a sense that decides the final knowledge of the perceived object. Hence sense centres situated in the cortex region of the brain represent the [[indriya]] buddhi[12]

Charak mentions that ''prānavāhi srotāmsi'' of [[indriya]] are situated in the head and are connected with the body as sun is connected with its rays. Therefore, diseases such as ardita(facial paralysis), cheshta nasha(paralysis) and disorders of eye movement etc. are due to trauma to the head [Ca. Sa. [[Siddhi Sthana]] 9/4]. In this chapter, the physical location of all the [[indriya]] has been mentioned to be the head, hence on the basis of these observations, it can be concluded that the [[indriya]]-[[buddhi]] are also situated in head.[[Indriya]] [[buddhi] is that vital part of a sense that decides the final knowledge of the perceived object. Hence sense centres situated in the cortex region of the brain represent the [[indriya]] [[buddhi]][12]

   

   

'''Classification of shiroroga:''' Generally, ''shiroroga'' implies any type of disease afflicting the head. Therefore, Charak enlisted diseases such as hemicrania (''ardhavabhedaka''), headache (''sarvam va rujyati shirah''), coryza (''pratishyaya''), diseases of mouth, nose, eyes and ears which cause headache (''mukha-nasa-akshi-karna-roga''), giddiness/vertigo (''sirobhramah''), facial paralysis (''ardita''), tremors of the head (''shirasah kampa'') and stiffness of the neck, nape and jaw (''gala-manya-hanu-grahah'') as ''shiroroga''. Hence, in general, shiroroga includes diseases occurring in the skull, its orifices and the structure related to it. As per this classification ''shiroroga'' includes ''vatika, paittika, kaphaja, sannipataja'' and ''krimija shiroroga''.   

'''Classification of shiroroga:''' Generally, ''shiroroga'' implies any type of disease afflicting the head. Therefore, Charak enlisted diseases such as hemicrania (''ardhavabhedaka''), headache (''sarvam va rujyati shirah''), coryza (''pratishyaya''), diseases of mouth, nose, eyes and ears which cause headache (''mukha-nasa-akshi-karna-roga''), giddiness/vertigo (''sirobhramah''), facial paralysis (''ardita''), tremors of the head (''shirasah kampa'') and stiffness of the neck, nape and jaw (''gala-manya-hanu-grahah'') as ''shiroroga''. Hence, in general, shiroroga includes diseases occurring in the skull, its orifices and the structure related to it. As per this classification ''shiroroga'' includes ''vatika, paittika, kaphaja, sannipataja'' and ''krimija shiroroga''.   

In addition, in [[Siddhi Sthana]], four more diseases occurring in the head have been described in detail viz. ''shankhaka, ardhavabhedaka,'' ''suryavarta,'' and ''anantavata''. [Cha.Sa.[[Siddhi Sthana]] 9/71-87] In these ''shiroroga'', [[nasya]](nasal errhines) has been indicated. [Cha.Sa.[[Siddhi Sthana]] 9/88] In all nine ''shiroroga'' (five in this chapter, and four in [[Siddhi Sthana]]) that mention headache as a key symptom. Other varieties of ''shiroroga'' mentioned in other texts are ''raktaja'' and ''kshayaja'' <ref>Sushruta. Uttara Tantra, Cha.25 Shirorogavijnaniya Adhyaya verse 3. In: Jadavaji Trikamji Aacharya, Editors. Sushruta Samhita. 8th ed. Varanasi: Chaukhambha Orientalia;2005.</ref> and ''shirah-kampa''. [A.H.Uttara Sthana 23/9]<ref>Vagbhata. Uttara Sthana, Cha.23 Shororogavijnaniya Adhyaya verse 9. In: Harishastri Paradkar Vaidya, Editors. Ashtanga Hridayam. 1st ed. Varanasi: Krishnadas Academy;2000.</ref>(Verse 6)

In addition, in [[Siddhi Sthana]], four more diseases occurring in the head have been described in detail viz. ''shankhaka, ardhavabhedaka,'' ''suryavarta,'' and ''anantavata''. [Cha.Sa.[[Siddhi Sthana]] 9/71-87] In these ''shiroroga'', [[nasya]](nasal errhines) has been indicated. [Cha.Sa.[[Siddhi Sthana]] 9/88] In all nine ''shiroroga'' (five in this chapter, and four in [[Siddhi Sthana]]) that mention headache as a key symptom. Other varieties of ''shiroroga'' mentioned in other texts are ''raktaja'' and ''kshayaja'' <ref>Sushruta. Uttara Tantra, Cha.25 Shirorogavijnaniya Adhyaya verse 3. In: Jadavaji Trikamji Aacharya, Editors. Sushruta Samhita. 8th ed. Varanasi: Chaukhambha Orientalia;2005.</ref> and ''shirah-kampa''. [A.H.Uttara Sthana 23/9]<ref>Vagbhata. Uttara Sthana, Cha.23 Shororogavijnaniya Adhyaya verse 9. In: Harishastri Paradkar Vaidya, Editors. Ashtanga Hridayam. 1st ed. Varanasi: Krishnadas Academy;2000.</ref>(Verse 6)

The five types of ''hridroga'' described in this chapter are also caused by vitiated [[dosha]] and ''krimi''. In all these conditions pain in the chest is a common feature, the intensity of which varies according to the involved [[dosha']]. For example in [[vata]], pain is accompanied by extra systole/ fibrillation (''vepathu''), sense of emptiness in the heart region (''shunyata''), and hyperkinetic heart and thrill (''dara''). A ''pittaja'' type ''hridroga'' is indicated by a burning sensation in the precordial region with fainting, giddiness and perspiration. In ''kaphaja'' type ''hridroga'', there is heaviness in the precordial area, ''suptam'' (bradycardia or decreased diastolic stretching) and a stony sensation (pericardial calcification as in constrictive pericarditis) in heart region.

The five types of ''hridroga'' described in this chapter are also caused by vitiated [[dosha]] and ''krimi''. In all these conditions pain in the chest is a common feature, the intensity of which varies according to the involved [[dosha]]. For example in [[vata]], pain is accompanied by extra systole/ fibrillation (''vepathu''), sense of emptiness in the heart region (''shunyata''), and hyperkinetic heart and thrill (''dara''). A ''pittaja'' type ''hridroga'' is indicated by a burning sensation in the precordial region with fainting, giddiness and perspiration. In ''kaphaja'' type ''hridroga'', there is heaviness in the precordial area, ''suptam'' (bradycardia or decreased diastolic stretching) and a stony sensation (pericardial calcification as in constrictive pericarditis) in heart region.

Description of ''krimija hridroga'' indicates a very serious condition. As mentioned earlier, infestation starts with one chamber of the heart and then spreads and consumes (''bhakshyanti'') tissues across the entire heart.The patient of ''krimija hridroga'' feels severe pain in the precordial region, as if heart is being pricked/pierced by needles or cut by weapons and is a very grave heart condition that may lead to immediate death. Therefore it is a severe condition and should be promptly diagnosed and managed. It may manifest as chest pain, arrhythmia, heart failure, acute myocardial infarction-like syndrome with normal coronary arteries, ventricular arrhythmia, and loss of right ventricular function leading to sudden death. (Verse 36-40).

Description of ''krimija hridroga'' indicates a very serious condition. As mentioned earlier, infestation starts with one chamber of the heart and then spreads and consumes (''bhakshyanti'') tissues across the entire heart.The patient of ''krimija hridroga'' feels severe pain in the precordial region, as if heart is being pricked/pierced by needles or cut by weapons and is a very grave heart condition that may lead to immediate death. Therefore it is a severe condition and should be promptly diagnosed and managed. It may manifest as chest pain, arrhythmia, heart failure, acute myocardial infarction-like syndrome with normal coronary arteries, ventricular arrhythmia, and loss of right ventricular function leading to sudden death. (Verse 36-40).