Changes

Inflammatory mediators released by peripheral mononuclear phagocytes and other immune cells induces fever. Fever inducing cytokines are transported from blood to brain. Prostaglandin E2 (PGE2) in the brain is believed to be the principle downstream mediator of fever. Inhibiting the production of PGE2 is a well known mechanism of antipyretics.<ref name=AshokBK>Ashok BK, Ravishankar B, Prajapati PK, Bhat SD. Antipyretic activity of GuduchiGhrita formulations in albino rats. Ayu. 2010 Jul;31(3):367-70. doi: 10.4103/0974-8520.77162. PMID: 22131741; PMCID: PMC3221073</ref>  

Inflammatory mediators released by peripheral mononuclear phagocytes and other immune cells induces fever. Fever inducing cytokines are transported from blood to brain. Prostaglandin E2 (PGE2) in the brain is believed to be the principle downstream mediator of fever. Inhibiting the production of PGE2 is a well known mechanism of antipyretics.<ref name=AshokBK>Ashok BK, Ravishankar B, Prajapati PK, Bhat SD. Antipyretic activity of GuduchiGhrita formulations in albino rats. Ayu. 2010 Jul;31(3):367-70. doi: 10.4103/0974-8520.77162. PMID: 22131741; PMCID: PMC3221073</ref>  

Many drugs are reported to be having antipyretic action. A few of them are decoction and alcoholic extract of amlakyadigana (combination of Emblica officinalis Gaertn. (Amalaki), Terminalia chebulaRetz.(Haritaki), Piper longum L. (Pippali), and Plumbago zeylenica L. (Chitraka);<>Timbadiya MJ, Nishteswar K, Acharya R, Nariya MB. Experimental evaluation of antipyretic and analgesic activities of AmalakyadiGana: An Ayurvedic formulation. Ayu. 2015 Apr-Jun;36(2):220-4. doi: 10.4103/0974-8520.175554. PMID: 27011727; PMCID: PMC4784136</ref> Aeginetia indica<></ref> , Grapevine leaf extract (Vitis vinifera)<>Aouey B, Samet AM, Fetoui H, Simmonds MSJ, Bouaziz M. Anti-oxidant, anti-inflammatory, analgesic and antipyretic activities of grapevine leaf extract (Vitis vinifera) in mice and identification of its active constituents by LC-MS/MS analyses. Biomed Pharmacother. 2016 Dec;84:1088-1098. doi: 10.1016/j.biopha.2016.10.033. Epub 2016 Oct 22. PMID: 27780137.</ref> , Cissampelos pareira Linn. , Cyclea peltata<>Singh SG, Nishteswar K, Patel BR, Nariya M. Comparative antipyretic and analgesic activities of Cissampelos pareira Linn. and Cycleapeltata (Lam.) Hook. F. & Thomas. Ayu. 2016 Jan-Mar;37(1):62-66. doi: 10.4103/ayu.AYU_208_14. PMID: 28827957; PMCID: PMC5541469</ref>  and Guduchi ghrita.<ref name=AshokBK/>

Many drugs are reported to be having antipyretic action. A few of them are decoction and alcoholic extract of amlakyadigana (combination of Emblica officinalis Gaertn. (Amalaki), Terminalia chebulaRetz.(Haritaki), Piper longum L. (Pippali), and Plumbago zeylenica L. (Chitraka);<ref>Timbadiya MJ, Nishteswar K, Acharya R, Nariya MB. Experimental evaluation of antipyretic and analgesic activities of AmalakyadiGana: An Ayurvedic formulation. Ayu. 2015 Apr-Jun;36(2):220-4. doi: 10.4103/0974-8520.175554. PMID: 27011727; PMCID: PMC4784136</ref> Aeginetia indica<ref>Reza MS, Jashimuddin M, Ahmed J, Abeer M, Naznin NE, Jafrin S, Haque ME, Barek MA, UdDaula AFMS. Pharmacological investigation of analgesic and antipyretic activities of methanol extract of the whole part of Aeginetia indica. J Ethnopharmacol. 2021 Feb 7;271:113915. doi: 10.1016/j.jep.2021.113915. Epub ahead of print. PMID: 33567308</ref> , Grapevine leaf extract (Vitis vinifera)<ref>Aouey B, Samet AM, Fetoui H, Simmonds MSJ, Bouaziz M. Anti-oxidant, anti-inflammatory, analgesic and antipyretic activities of grapevine leaf extract (Vitis vinifera) in mice and identification of its active constituents by LC-MS/MS analyses. Biomed Pharmacother. 2016 Dec;84:1088-1098. doi: 10.1016/j.biopha.2016.10.033. Epub 2016 Oct 22. PMID: 27780137.</ref> , Cissampelos pareira Linn. , Cyclea peltata<ref>Singh SG, Nishteswar K, Patel BR, Nariya M. Comparative antipyretic and analgesic activities of Cissampelos pareira Linn. and Cycleapeltata (Lam.) Hook. F. & Thomas. Ayu. 2016 Jan-Mar;37(1):62-66. doi: 10.4103/ayu.AYU_208_14. PMID: 28827957; PMCID: PMC5541469</ref>  and Guduchi ghrita.<ref name=AshokBK/>

Controlled clinical trials of these medicines are required to establish their efficacy as treatment option to established anti pyretic drugs.

Controlled clinical trials of these medicines are required to establish their efficacy as treatment option to established anti pyretic drugs.