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!Drug!!Observations  

!Drug!!Observations  

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|Embelia ribes(vidanga) ||Root powder in 100g/kg in rats exhibited 100% inhibition of pregnancy in albino rats.  

|Embelia ribes(vidanga) ||Root powder in 100g/kg in rats exhibited 100% inhibition of pregnancy in albino rats.<ref>Garg SK, Garg GP, Screening of Indian Plants for antifertility activity,Indian Journal of Experimental Biology, 16(10), 1978. Pg 1077-79.</ref>

Embelin 50-100mg/kg in rats from day 1 to day 7 of pregnancy showed 85.71% anti-implantation activity, significant anti-estrogenic and progestational properties.

Embelin 50-100mg/kg in rats from day 1 to day 7 of pregnancy showed 85.71% anti-implantation activity, significant anti-estrogenic and progestational properties.<ref>Prakash AO, Antifertility investigaions, Embelin- an oral contraceptive of plant origin, Planta Med 41(3), 1981, pg 259—66.</ref>

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|Abies webbiana(Talisa) || Benzene and alcoholic extracts of leaf produced 51% anti- implantation activity.  

|Abies webbiana(Talisa) || Benzene and alcoholic extracts of leaf produced 51% anti- implantation activity.<ref>Anonymous, Pharmacological investigations of certain medicinal plants & compound formulations used Ayurveda and Sidha , CCRAS New Delhi, 1996, 474.</ref>

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|Azadiracta indica (nimba)||Bark extract had shown in vitro spermicidal activity.  

|Azadiracta indica (nimba)||Bark extract had shown in vitro spermicidal activity.<ref>Vnita Bhargava, Prakash AO, Spermicidal activity in vitro of bark extract of Azadiracta indica in rats,Ancient Science of Life 20(1/2)</ref>

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|Daucus carota(grinjana)||Extracts of the seeds showed petroleum, ether, benzene, alcohol & water showed 85%, 95%, 92%,50% anti-implantation activity respectively.  

|Daucus carota(grinjana)||Extracts of the seeds showed petroleum, ether, benzene, alcohol & water showed 85%, 95%, 92%,50% anti-implantation activity respectively.<ref>Uduppa KN & Singh RH,Antifertility property of the alcoholic extract of carrot seed, J Res Indian Med Yoga Homeo 14(1),1979, pg 128-30.</ref>

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|Hibiscus rosasinensis(Japa)||Alcoholic extract of flower showed 50-60% inhibition of pregnancy at 200mg/kg dose.Benzene extract produced 100% antifertility effect in 250mg/kg.  

|Hibiscus rosasinensis(Japa)||Alcoholic extract of flower showed 50-60% inhibition of pregnancy at 200mg/kg dose.Benzene extract produced 100% antifertility effect in 250mg/kg.<ref>Kholkute SD,Uduppa KN, Antifertility properties of Hibiscus rosasinensis, J Res Indian Med,9(4), 1974, pg 99.</ref>

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|Plumbago rosea / Plumbago zeylanica(chitraka)||Root powder in a dose of 100mg/100g from Day 1 to Day 7 of pregnancy in albino rats showed 100% antifertility activity.  

|Plumbago rosea / Plumbago zeylanica(chitraka)||Root powder in a dose of 100mg/100g from Day 1 to Day 7 of pregnancy in albino rats showed 100% antifertility activity.<ref>Anonymous, Pharmacological investigations of certain medicinal plants & compound formulations used Ayurveda and Sidha , CCRAS New Delhi, 1996, 84.</ref>

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|Terminalia arjuna(arjuna)||Anti-zygotic, anti-implantation, abortifacient activities.  

|Terminalia arjuna(arjuna)||Anti-zygotic, anti-implantation, abortifacient activities.<ref>Lal B, Uduppa KN, A preliminary study of anti- fertility effect of an indigenous drug- arjuna(Terminala arjuna), JRAS,14(1),1991, Pg 165-169.</ref>

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|Mesua ferrea(Nagaksara)|| Flowers exhibited anti-implantation activity in female rats.  

|Mesua ferrea(Nagaksara)|| Flowers exhibited anti-implantation activity in female rats.<ref>Seshadri c & Pillai SR, Antifertility activity of a compound Ayurvedic preparation, J Sci Res Pl Med 2 (1 &2),1981.pg 1-3.</ref>

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The Central Council for Research in Ayurvedic Sciences (CCRAS), working under the Ministry of AYUSH carried out the screening of many herbal and herbo-mineral drugs for the contraceptive activity under the Research Scheme for screening of contraceptive agents.

The Central Council for Research in Ayurvedic Sciences (CCRAS), working under the Ministry of AYUSH carried out the screening of many herbal and herbo-mineral drugs for the contraceptive activity under the Research Scheme for screening of contraceptive agents.

*A compound drug called AYUSH AC-V, which is a combination of Abes webbiana(talisa patra) and red orche (gairika), showed 100% anti-implantation effect on multigravida  rats.  

*A compound drug called AYUSH AC-V, which is a combination of Abes webbiana(talisa patra) and red orche (gairika), showed 100% anti-implantation effect on multigravida  rats.<ref>Revan Siddappa et al; Evaluation of contraceptive effect of a traditional medicine on albino rats, Aryavaidyan Vol.XXIII, No.1, Aug-Oct 2009, Pp 9-12</ref>

*Another coded drug called AYUSH AC-IV, Embelia ribes (vidanga), Laccardia lacca (laksha), Areca catechu (puga) and Saraca asoka (ashoka) in equal parts, 1gm/day in two divided doses in 281 women for 15 days (D4-D18). There was no pregnancy reported even after 10th cycle.  

*Another coded drug called AYUSH AC-IV, Embelia ribes (vidanga), Laccardia lacca (laksha), Areca catechu (puga) and Saraca asoka (ashoka) in equal parts, 1gm/day in two divided doses in 281 women for 15 days (D4-D18). There was no pregnancy reported even after 10th cycle.<ref>Gowri N, Srinivasn K, Venkataraghavan S. Clinical study of ac-4-an ayurvedic compound preparation as an oral contraceptive. Anc Sci Life. 1982;2(2):79-83.</ref>

*The various clinical trials conducted by CCRAS, the combination of Piper longum Linn(pippali), Embelia ribes(vidanga), borax(tankana) known as “pippalyadi yoga” was tested in 722 women in tablet form 1g/day. It effectively prevented pregnancy in 98.42%.  

*The various clinical trials conducted by CCRAS, the combination of Piper longum Linn(pippali), Embelia ribes(vidanga), borax(tankana) known as “pippalyadi yoga” was tested in 722 women in tablet form 1g/day. It effectively prevented pregnancy in 98.42%.<ref>https://eparlib.nic.in/bitstream/123456789/574253/1/9271.pdf</ref>

*Oil of Azadiracta indica A Juss (nimba), 1 ml intra vaginally before each coitus, tested in 225 women with proven fertility showed 98.7% result in prevention of pregnancy and in a dose of 3 ml (intra vaginally before each coitus) showed 100% result in prevention of pregnancy during the study period of 12 cycles.

*Oil of Azadiracta indica A Juss (nimba), 1 ml intra vaginally before each coitus, tested in 225 women with proven fertility showed 98.7% result in prevention of pregnancy and in a dose of 3 ml (intra vaginally before each coitus) showed 100% result in prevention of pregnancy during the study period of 12 cycles.

*“Praneem”, a purified extract from the dried seeds of Azadirachta indica (Neem), extract from the pericarp of fruits of Sapindus species and quinine hydrochloride, showed contraceptive efficacy in rabbits and monkeys after intra vaginal application. Precoital application of the cream provided complete protection against pregnancy in rabbits in the 1st 30 minutes after application. The conception rate was acceptable at 60 minutes (7%), but thereafter it climbed to unacceptable levels (28.6% at 90 minutes and 75% at 12 hours).

*“Praneem”, a purified extract from the dried seeds of Azadirachta indica (Neem), extract from the pericarp of fruits of Sapindus species and quinine hydrochloride, showed contraceptive efficacy in rabbits and monkeys after intra vaginal application. Precoital application of the cream provided complete protection against pregnancy in rabbits in the 1st 30 minutes after application. The conception rate was acceptable at 60 minutes (7%), but thereafter it climbed to unacceptable levels (28.6% at 90 minutes and 75% at 12 hours).<ref>Garg S, Taluja V, Upadhyay SN, Talwar GP , Studies on the contraceptive efficacy of Praneem polyherbal cream, Contraception, 1993 Dec;48(6):591-6</ref>

==References==

==References==