Changes

==== Antiemetic Activity ====

==== Antiemetic Activity ====

The ethanol extract of fruit peel of Luffa cylindrica showed significant ( p < 0.001) antiemetic effect in young chicks. The protective effect of the extract against copper sulfate induced retching in young chicks is possibly by peripheral action as the oral copper sulfate induces emesis by peripheral action through excitation of visceral afferent nerve fibers of the Gastro Intestinal Tract (GIT). [19] It has also been established that the peripheral 5-Hydroxy Tryptamine 3 (5-HT3), 5-Hydroxy tryptamine 4 (5-HT4) [20] or Neoro Kynin 1 (NK1) [21] receptors are involved in emesis. Therefore, it may be said that the ethanol extract of Luffa cylindrica fruit peel produced anti-emetic activity by receptor antagonism and has peripheral anti-emetic action.

The ethanol extract of fruit peel of Luffa cylindrica showed significant ( p < 0.001) antiemetic effect in young chicks. The protective effect of the extract against copper sulfate induced retching in young chicks is possibly by peripheral action as the oral copper sulfate induces emesis by peripheral action through excitation of visceral afferent nerve fibers of the Gastro Intestinal Tract (GIT).<ref>Bowman, W. C. & Rand M. J. (1980). Textbook of pharmacology, Oxford, Blackwell Scientific Publication.</ref>.It has also been established that the peripheral 5-Hydroxy Tryptamine 3 (5-HT3), 5-Hydroxy tryptamine 4 (5-HT4)<ref>20. Fukui, H., Yamamoto, M., Sasaki, S. & Sato, S. (1993). Involvement of 5-HT3 receptors and vagal afferents in copper sulfate- and cisplatin-induced emesis in monkeys. European Journal of Pharmacology, 249, 13-18.</ref>  or Neoro Kynin 1 (NK1)<ref>Ariumi, H., Saito, R., Nago, S., Hyakusoku, M., Takano, Y. & Kamiya, H-O. (2000). The role of tachykinin NK1 receptors in the area postrema of ferrets in emesis. Neuroscience Letters, 286,123-126.</ref>receptors are involved in emesis. Therefore, it may be said that the ethanol extract of Luffa cylindrica fruit peel produced anti-emetic activity by receptor antagonism and has peripheral anti-emetic action.

Anti-emetic activity by using copper sulfate proposed 5-HT3, 5-HT4 or NK1 receptors antagonism. Therefore it may be said that the extract was able to effectively prevent its effect and has a peripheral anti-emetic action.

Anti-emetic activity by using copper sulfate proposed 5-HT3, 5-HT4 or NK1 receptors antagonism. Therefore it may be said that the extract was able to effectively prevent its effect and has a peripheral anti-emetic action.