Changes

== Vidhi Vimarsha (Applied Inferences) ==

== Vidhi Vimarsha (Applied Inferences) ==

*''Ushna-Tikshna-Sukshma-Vyavayi'' and ''vikasi'' are the common properties of the ''Vamanakarma dravya''. According to Sushruta, the ''ushna'' property has ''pachana karma'' (S.Su.46/515).Chakrapani (the commentator on [[Charaka Samhita]]) states that ''ushna'' means ''ushna veeryam''. This has been cleared in AshtÁnga Sangraha by Vagabhat and the function are like ''dahana'' and ''pachana'' and having ability to decrease ''vata'' and ''kapha dosha'' <ref>Ashtang Sangraha of Vriddha Vagbhata with Shalilekha Sanskrit commentary by Indu, Chaukhambha Sanskrit Series Office, Varanasi. Sutra sthana 17/15 </ref>. Sushruta defines that ''tikshna'' as the property produces ''daha, paka'' and ''srava''<ref> Sushruta Samhita of Susruta, with the Nibandhasangraha Commentary of Sri Dlhanacharya, Edited by Vaidya Jadavji Trikamji Acharya, Published by Chaukhambha Orientalia, Varanasi, 1992 Sutra sthana 46/518</ref>. According to Charaka, ''Tikshna guna'' is ''vichchindana'' <ref> Charaka Samhita by Agnivesha revised by Charaka and Dridhabala with the [[Ayurveda]]-Dipika Commentary of Chakrapanidatta, Edited by Vaidya Jadavji Trikamji Acharya, published by Chaukhambha Sanskrit Sansthan, Varanasi, 1984. Kalpa sthana 1/5</ref>. Chakrapani clarified the word as ''vichchindayati'', means breaking down the complex morbid matter into simple molecules. The ''Sukshma guna'' reaches to minute ''srotasa'' and remove the morbid matter to bring it to reach the ''amashaya'' according to Dalhana (S.Ci.33/33). The ''Vyavayi'' drugs, when administered initiate the action immediately and thereafter bio-transformation takes place. Sushruta has clarified that ''Vikasi'' drugs causes laxity in ''dhatubandhana'' (S.Su. 46/523).Due to above mentioned properties ''Vamana'' drugs are beneficial for therapeutic emesis.  

*''Ushna-Tikshna-Sukshma-Vyavayi'' and ''vikasi'' are the common properties of the ''Vamanakarma dravya''. According to Sushruta, the ''ushna'' property has ''pachana karma'' (S.Su.46/515).Chakrapani (the commentator on [[Charaka Samhita]]) states that ''ushna'' means ''ushna veeryam''. This has been cleared in AshtÁnga Sangraha by Vagabhat and the function are like ''dahana'' and ''pachana'' and having ability to decrease ''vata'' and ''kapha dosha'' <ref>Ashtang Sangraha of Vriddha Vagbhata with Shalilekha Sanskrit commentary by Indu, Chaukhambha Sanskrit Series Office, Varanasi. Sutra sthana 17/15 </ref>. Sushruta defines that ''tikshna'' as the property produces ''daha, paka'' and ''srava''<ref> Sushruta Samhita of Susruta, with the Nibandhasangraha Commentary of Sri Dlhanacharya, Edited by Vaidya Jadavji Trikamji Acharya, Published by Chaukhambha Orientalia, Varanasi, 1992 Sutra sthana 46/518</ref>. According to Charaka, ''Tikshna guna'' is ''vichchindana'' <ref> Charaka Samhita by Agnivesha revised by Charaka and Dridhabala with the [[Ayurveda]]-Dipika Commentary of Chakrapanidatta, Edited by Vaidya Jadavji Trikamji Acharya, published by Chaukhambha Sanskrit Sansthan, Varanasi, 1984. Kalpa sthana 1/5</ref>. Chakrapani clarified the word as ''vichchindayati'', means breaking down the complex morbid matter into simple molecules. The ''Sukshma guna'' reaches to minute ''srotasa'' and remove the morbid matter to bring it to reach the ''amashaya'' according to Dalhana (S.Ci.33/33). The ''Vyavayi'' drugs, when administered initiate the action immediately and thereafter bio-transformation takes place. Sushruta has clarified that ''Vikasi'' drugs causes laxity in ''dhatubandhana'' (S.Su. 46/523).Due to above mentioned properties ''Vamana'' drugs are beneficial for therapeutic emesis.  

*''Sharngadhara'' in ''Sharngadhara Samhita'' stated that ''apakva pitta'' and ''kapha'' are forcefully expelled out through the upward route. Thus ''vamana'' is the best for vitiated ''kapha'' and ''apakva pitta'' <ref>Sharangadhara Samhita of  Sharangadhara with the commentary of Addhmala’Dipika commentary , Chaukhambha Orientalia, Varanasi-221001, Third Edition-1983.Purva khanda 8/7 </ref>.

*''Sharngadhara'' in ''Sharngadhara Samhita'' stated that ''apakva pitta'' and ''kapha'' are forcefully expelled out through the upward route. Thus ''vamana'' is the best for vitiated ''kapha'' and ''apakva pitta'' <ref>Sharangadhara Samhita of  Sharangadhara with the commentary of Addhmala’Dipika commentary , Chaukhambha Orientalia, Varanasi-221001, Third Edition-1983.Purva khanda 8/7 </ref>.

=== Phytochemistry ===

=== Phytochemistry of madanaphala===

The drug ''Madanaphala'' is botanically identified as Catunaregum spinosa (Thunb.) Randia Spinosa Poir. Syn.R.DumatrumLam. The phytochemical studies on the fruits of  R. spinosa  revealed presence of mixture of saponins viz. randia acid or acid saponin has been isolated from the pulp; the two saponins occur in the fruit at all stages of ripening. The fruits of R. spinosa contain a toxic saponin of oleanolic acid. They also contain leucocyanidin and mannitol. The activity of the drug is attributed to the presence of saponins which occur to the extent of 2-3 % in fresh fruits and about 10% in dried whole fruit. The saponins are concentrated mostly in the pulp. A mixture of two saponins, viz. randialic or neutral saponin (m.p. 289-2900C  decomp.)and randialic acid or acid saponin (m.p. 2600 C decomp.) has been isolated from the pulp.On complete hydrolysis both the saponins yield Oleanolic acid as Sapogenin. Ursosaponin, isolated from the ethanolic extract of the dried whole fruit, gave ursolic acid and glucose. Randianin, isolated from the fruit, gave a haemolytic triterpenoid saponin.  

The drug ''Madanaphala'' is botanically identified as Catunaregum spinosa (Thunb.) Randia Spinosa Poir. Syn.R.DumatrumLam. The phytochemical studies on the fruits of  R. spinosa  revealed presence of mixture of saponins viz. randia acid or acid saponin has been isolated from the pulp; the two saponins occur in the fruit at all stages of ripening. The fruits of R. spinosa contain a toxic saponin of oleanolic acid. They also contain leucocyanidin and mannitol. The activity of the drug is attributed to the presence of saponins which occur to the extent of 2-3 % in fresh fruits and about 10% in dried whole fruit. The saponins are concentrated mostly in the pulp. A mixture of two saponins, viz. randialic or neutral saponin (m.p. 289-2900C  decomp.)and randialic acid or acid saponin (m.p. 2600 C decomp.) has been isolated from the pulp.On complete hydrolysis both the saponins yield Oleanolic acid as Sapogenin. Ursosaponin, isolated from the ethanolic extract of the dried whole fruit, gave ursolic acid and glucose. Randianin, isolated from the fruit, gave a haemolytic triterpenoid saponin.  

* The seeds are reported to be free from saponins. They contain fat (1.5 %), protein (14.2 %), mucilage, resin, organic acid (1.4 %) and a minute quantity of an unidentified alkaloid. The bark contains scopoletin, d-mannitol and a mixture of saponins. The saponins on hydrolysis yield glucose, xylose, rhamnose, and two triterpenic acid sapogenins designated as randialic acid.One is [19 (α)-hydroxyursolic acid, C30H48O4; methyl ester, m.p. 200-2020] and another is randialic acid (19-dehydroursolic acid, C30H48O3; m.p. 256-2570). The roots contain scopoletin and d-mannitol (Navneet et al. 2010).

* The seeds are reported to be free from saponins. They contain fat (1.5 %), protein (14.2 %), mucilage, resin, organic acid (1.4 %) and a minute quantity of an unidentified alkaloid. The bark contains scopoletin, d-mannitol and a mixture of saponins. The saponins on hydrolysis yield glucose, xylose, rhamnose, and two triterpenic acid sapogenins designated as randialic acid.One is [19 (α)-hydroxyursolic acid, C30H48O4; methyl ester, m.p. 200-2020] and another is randialic acid (19-dehydroursolic acid, C30H48O3; m.p. 256-2570). The roots contain scopoletin and d-mannitol (Navneet et al. 2010).

=== Pharmacological activity ===

=== Pharmacological activity of madanaphala ===

The drug was reported to have antibacterial, anti-allergic, anti-inflammatory, analgesic  and immunomodulatory Activity <ref>Patel Ritesh G, Pathak Nimish L, Rathod Jaimik D, Dr.L.D.Patel and Bhatt Nayna M. Phytopharmacological Properties of  Randia dumetorum  as a Potential Medicinal Tree: An Overview , Journal of Applied Pharmaceutical Science 01 (10); 2011: 24-26. ISSN: 2231-3354.</ref>. Antileishmanial activity ,antitumor activity and stimulant action on uterus was also reported.<ref>Navneet K. Singh, Arun K. Mishra , Jeetendra K. Gupta , S. Jayalakshmi ,Randia spinosa (poir.): ethnobotany, phytochemistry and pharmacology -a review  International Journal of Pharmaceutical Sciences Review and Research Volume 4 (1), Sep.–Oct.2010</ref>.

The drug was reported to have antibacterial, anti-allergic, anti-inflammatory, analgesic  and immunomodulatory Activity <ref>Patel Ritesh G, Pathak Nimish L, Rathod Jaimik D, Dr.L.D.Patel and Bhatt Nayna M. Phytopharmacological Properties of  Randia dumetorum  as a Potential Medicinal Tree: An Overview , Journal of Applied Pharmaceutical Science 01 (10); 2011: 24-26. ISSN: 2231-3354.</ref>. Antileishmanial activity ,antitumor activity and stimulant action on uterus was also reported.<ref>Navneet K. Singh, Arun K. Mishra , Jeetendra K. Gupta , S. Jayalakshmi ,Randia spinosa (poir.): ethnobotany, phytochemistry and pharmacology -a review  International Journal of Pharmaceutical Sciences Review and Research Volume 4 (1), Sep.–Oct.2010</ref>.