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→Contemporary approach:
==Contemporary approach: ==
==Contemporary approach: ==
• In conventional physiology, the concept of meda dhatu is perceived in view of adipose tissue, fats, and lipids. Fat is found primarily as a continuous layer or as a deposition on membranes such as mesenteries or greater omentum. It is usually found around kidneys helping to hold them in place around the intestine and furrows of the heart. Fat is found in marrows of long bones also.
• In conventional physiology, the concept of meda dhatu is perceived in view of adipose tissue, fats, and lipids. <ref>Vandana Verma, Sonam Agrawal, & Sangeeta Gehlot. (2020). Exploration of Ayurveda blueprint on clinical physiology of Meda (adipose tissue) and Majja Dhatu (bone marrow) in context to obesity. International Journal of Research in Pharmaceutical Sciences, 11(1), 358-367. https://doi.org/10.26452/ijrps.v11i1.1830</ref> Fat is found primarily as a continuous layer or as a deposition on membranes such as mesenteries or greater omentum. It is usually found around kidneys helping to hold them in place around the intestine and furrows of the heart. Fat is found in marrows of long bones also.<ref>Dwarkanath C. Introduction to Kayachikitsa. Chaukhambha Orientalia. Varanasi; 1996. Third edition.pg.346</ref>
===Origin and formation:===
===Origin and formation:===
Adipose tissue is a loose connective tissue including adipocytes, fibroblasts, vascular endothelial cells, and some immune cells.
Adipose tissue is a loose connective tissue including adipocytes, fibroblasts, vascular endothelial cells, and some immune cells.<ref>Available from https://embryology.med.unsw.edu.au/embryology/index.php/Adipose_Tissue_Development cited on 18/05/2020</ref>
Adipocytes, or lipocytes or fat cells, primarily compose adipose tissue and store fat as energy. Adipocytes are derived from mesenchymal stem cells through adipogenesis.
Adipocytes, or lipocytes or fat cells, primarily compose adipose tissue and store fat as energy.<ref>Birbrair A, Zhang T, Wang ZM, Messi ML, Enikolopov GN, Mintz A, Delbono O (August 2013). "Role of pericytes in skeletal muscle regeneration and fat accumulation". Stem Cells and Development. 22 (16): 2298–314. doi:10.1089/scd.2012.0647. PMC 3730538. PMID 23517218</ref> Adipocytes are derived from mesenchymal stem cells through adipogenesis.
There are two types of adipose tissue, white adipose tissue (WAT) and brown adipose tissue (BAT), which are also known as white and brown fat, respectively, and comprise two types of fat cells.
There are two types of adipose tissue, white adipose tissue (WAT) and brown adipose tissue (BAT), which are also known as white and brown fat, respectively, and comprise two types of fat cells.
This pathophysiology can be linked as follows:
This pathophysiology can be linked as follows:
Excess nutrition leads to the expansion of fat mass and an increase in the size of adipocytes (hypertrophy). This leads to obesity. In the fat cells of obese individuals, there is increased production of metabolism modulators, such as glycerol, hormones, macrophage stimulating chemokines, and pro-inflammatory cytokines, leading to the development of insulin resistance. Insulin plays a major role in fat production in adipocytes, synthesis of unsaturated fatty acids, and stimulating lipogenesis. It also plays a role in the uptake of glucose by muscles. The malfunctioning of insulin in turn leads to diabetes.
Excess nutrition leads to the expansion of fat mass and an increase in the size of adipocytes (hypertrophy). This leads to obesity. In the fat cells of obese individuals, there is increased production of metabolism modulators, such as glycerol, hormones, macrophage stimulating chemokines, and pro-inflammatory cytokines, leading to the development of insulin resistance. Insulin plays a major role in fat production in adipocytes, synthesis of unsaturated fatty acids, and stimulating lipogenesis. It also plays a role in the uptake of glucose by muscles. The malfunctioning of insulin in turn leads to diabetes.
==Current researches: ==
==Current researches: ==