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=== Role of asthi dhatu as a vitiating factor in diseases ===
 
=== Role of asthi dhatu as a vitiating factor in diseases ===
• When the vitiated dosha afflict bone tissue(asthi dhatu),the tertiary fever (tritiyakajwara)is manifested. [Cha. Sa.[[ChikitsaSthana]] 3/64]
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• In fever, when the dosha are located in bone tissue (asthigatajwara) , they cause diarrhea, vomiting, pain in the bones, production of kujana (a sort of cooing sound),convulsive movement of the body. [Cha. Sa.ChikitsaSthana 3/80]
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• When the vitiated doshas afflict bone tissue(asthi dhatu), the tertiary fever (tritiyakajwara)is manifested. [Cha. Sa.[[Chikitsa Sthana]] 3/64]
• Bone tissue is one among the eight locations of wounds (vrana).The other sites are skin, blood vessels, flesh, fat, ligament, vital parts and viscera. [Cha. Sa.ChikitsaSthana 25/26]
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• When vitiated vata is located in bones and marrow, it leads to splitting pain of bones and joints, arthralgia, loss of muscle strength, insomnia and continuous pain. [Cha Sa ChikitsaSthana 28/33]
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• In fever, when the dosha are located in bone tissue (asthigatajwara) , they cause diarrhea, vomiting, pain in the bones, production of kujana (a sort of cooing sound), convulsive movement of the body. [Cha. Sa.[[Chikitsa Sthana]] 3/80]
• When the vata is occluded by the osseous tissue, the patient likes hot touch (local sudation) and pressing. He has splitting pain and feels as though his body is being pricked with needles. [Cha Sa ChikitsaSthana 28/66]
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• When the wound(vrana) is deep to affect bones due to different types of injuries or destruction by the aggravated doshas, it looks like oyster shell. There is discharge(srava) mixed with marrow and blood. [Su. Sa. Sutra Sthana 22/8]
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• Bone tissue is one of the eight locations of wounds (vrana). The other sites are skin, blood vessels, flesh, fat, ligament, vital parts and viscera. [Cha. Sa.[[Chikitsa Sthana]] 25/26]
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• When vitiated vata is located in bones and marrow, it leads to splitting pain of bones and joints, arthralgia, loss of muscle strength, insomnia, and continuous pain. [Cha Sa [[Chikitsa Sthana]] 28/33]
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• When the vata is occluded by the osseous tissue, the patient likes hot touch (local sudation) and pressing. He has splitting pain and feels as though his body is being pricked with needles. [Cha Sa [[Chikitsa Sthana]] 28/66]
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• When the wound(vrana) is deep to affect bones due to different types of injuries or destruction by the aggravated doshas, it looks like an oyster shell. There is discharge(srava) mixed with marrow and blood.[Su. Sa. Sutra Sthana 22/8]
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=== Importance in prognosis ===
 
=== Importance in prognosis ===
 
• The fever (jwara) in which dosha are located in the bone tissue (asthi  dhatu) is difficult to treat.[Cha Sa ChikitsaSthana 3/83]
 
• The fever (jwara) in which dosha are located in the bone tissue (asthi  dhatu) is difficult to treat.[Cha Sa ChikitsaSthana 3/83]
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