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→Contemporary perspective
To summarize the content of ''Kalpa sthana'' of Charak samhita it appears that the information about most popular emetic and purgative drugs with various dosage forms is furnished. And more research is required to explain modus operandii of emetic and purgative drugs and their therapeutic applicability through evidence based clinical trials which were in vogue during those times.
To summarize the content of ''Kalpa sthana'' of Charak samhita it appears that the information about most popular emetic and purgative drugs with various dosage forms is furnished. And more research is required to explain modus operandii of emetic and purgative drugs and their therapeutic applicability through evidence based clinical trials which were in vogue during those times.
=== Important concepts in Kalpa Sthana ===
* Mode of action of [[Vamana]] and [[Virechana]] (Chapter 1 Verse 5)
* Factors responsible for potency of drug (Chapter 1 verse 7)
* Selection of soil and desha classification for collecting good quality medicinal plants (Chapter 1 verse 7-8)
* Ideal and forbidden areas for collecting medicinal plants (Chapter 1 verse 9)
* Time period of collection and harvesting herbs (Chapter 1 verse 10)
* Storage of herbs (Chapter 1 verse 11)
* Concept of [[Anupana]] (vehicle) (Chapter 1 verse 12)
* Nasal drug delivery of herbs (Chapter 1 verse 19, Chapter 3 verses 11-12, Chapter 4 verse 10, Chapter 10 verse 17)
* Concept of ascending dosage schedule (vardhamana matra) (Chapter 3 verse 13)
* Development of different dosage forms of purgatives according to constitution (Chapter 7 verse 28)
* Formulation of purgative drugs according to seasons (Chapter 7 verse 56 and 59)
* Formulation designing according to koshtha(Chapter 10 verse 17)
* Principles of indicating nomenclature of formulation (Chapter 12 verse 44)
* Concept of potentiation of drugs including the theory of antogonism and synergism (Chapter 12 verse 45-48)
* Categorization or classification of therapeutic response into mild, moderate and severe categories (Chapter 12 verse 50-56)
* Importance of assessment of roga bala and rogi bala ( severity of disease and strength of patient) for prescribing purification procedures(Chapter 12 verse 60)
* Management of residual [[dosha]] with food and medicated decoctions after purification therapies (Chapter 12 verse 66)
* Concept of examination of koshtha (status of gastrointestinal tract) while administering [[vamana]] and [[virechana]] drugs (Chapter 12 verse 67)
* Concept of sneha and ruksha [[virechana]] (Chapter 12 verse 82-83)
* Inhibiting factors fro prevention of purgative actions (Chapter 12 verse 80)
* Concept of posology based upon koshtha(status of gastro intestinal tract), vaya(age) and bala(strength) (Chapter 12 verse 86)
=== Important areas of research and its clinical applications ===
* Standardization of procedure of [[vamana]] and [[virechana]] karma
* Standardization of processes of different dosage forms
* Studies on procedures and processing of different [[anupana]] like Kwatha, Yavagu, Ksheerapaka, Swarasa, Shashkuli, Shadava, Raga, Shukta, Suramanda, Asava, Sura, Varit, Krishara, Panaka, Sauvira, Tushodaka, Avaleha, Shritapaka, Seedhu, Utkarika
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