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#In a study, 60 vishamajwara patients were selected. Out of which 24 patients were positive for malarial parasite test. The trial drug, Indrayavadi Vati was given in the dosage of 2-6gm for 7 days. After treatment, complete relief was observed in symptoms like headache, vomiting, nausea and rigors. Malarial parasite test was also negative after the treatment.<ref>Dal D K: Vishamajvara (malaria) chikitsatmakaadhyayana, Department of Kayachikitsa and Panchakarma, IPGT&RA, Jamnagar. MD Thesis, 1981</ref>
#In a study, 60 vishamajwara patients were selected. Out of which 24 patients were positive for malarial parasite test. The trial drug, Indrayavadi Vati was given in the dosage of 2-6gm for 7 days. After treatment, complete relief was observed in symptoms like headache, vomiting, nausea and rigors. Malarial parasite test was also negative after the treatment.<ref>Dal D K: Vishamajvara (malaria) chikitsatmakaadhyayana, Department of Kayachikitsa and Panchakarma, IPGT&RA, Jamnagar. MD Thesis, 1981</ref>
#In another study on vishamajwara, 34 patients were treated with Leucas cephalotes (dronapushpi) in the dosage 3 -6 gm for 20 days. Total 76.47% of patients were completely cured.<ref>Kashaih M (1983): A study on effect of certain indigenous drug in Vishamajvara, Department of Kaumarabhritya, IPGT&RA, Jamnagar</ref>
#In another study on vishamajwara, 34 patients were treated with Leucas cephalotes (dronapushpi) in the dosage 3 -6 gm for 20 days. Total 76.47% of patients were completely cured.<ref>Kashaih M (1983): A study on effect of certain indigenous drug in Vishamajvara, Department of Kaumarabhritya, IPGT&RA, Jamnagar</ref>
#Powder of Hymenodictyonexcelsum (BhramaraChallika) was given to 25 patients of vishamajwarain a dosage of 2gm thrice a day for 5 – 15 days. This drug is found more effective in anyedyushkajwara than santatajwara.<ref>Sarvaiya D B (1987): Dravyavigyana of Bhramara-Challika and its therapeutic effect on Vishamajvara,Department of Dravyaguna, IPGT&RA, Jamnagar</ref>
#Powder of Hymenodictyon excelsum (Bhramara Challika) was given to 25 patients of vishamajwara in a dosage of 2gm thrice a day for 5 – 15 days. This drug is found more effective in anyedyushkajwara than santatajwara.<ref>Sarvaiya D B (1987): Dravyavigyana of Bhramara-Challika and its therapeutic effect on Vishamajvara,Department of Dravyaguna, IPGT&RA, Jamnagar</ref>
#Clerodendroninermes and Leucas cephalotes were given in dosage of 3gm for 10 days. Significant results were obtained on cardinal symptoms of jvara for both these drugs.<ref>Varsha Solanki (1998): A comparative study of Clerodendroninermes and Leucas cephalotes on Vishamajvara, Department of Dravyaguna, IPGT&RA, Jamnagar</ref>
#Clerodendron inermes and Leucas cephalotes were given in dosage of 3gm for 10 days. Significant results were obtained on cardinal symptoms of jwara for both these drugs.<ref>Varsha Solanki (1998): A comparative study of Clerodendroninermes and Leucas cephalotes on Vishamajvara, Department of Dravyaguna, IPGT&RA, Jamnagar</ref>
#Total 23 patients with positive peripheral smear test for Plasmodium vivax were selected and treated with Siddharthakadi agada 3gm thrice a day for 1 week. Control group was treated with Chloroquine phosphate and Primaquine. Siddharthakadi agada has provided significant results in reducing the fever, rigor with chill, headache, bodyache, sweating, anorexia, weakness and cough. On comparison the patients treated with Siddharthakadi agada showed better results in controlling anorexia, headache and body ache. Peripheral smear test after seven days of treatment with agada was negative for all patients.<ref>RimpalVirsodiya (2006): Effect of Siddharthakadi Agada in the management of Malaria (Jvara), Department of Kayachikitsa, IPGT&RA, Jamnagar.</ref>
#Total 23 patients with positive peripheral smear test for Plasmodium vivax were selected and treated with Siddharthakadi agada 3gm thrice a day for 1 week. Control group was treated with Chloroquine phosphate and Primaquine. Siddharthakadi agada has provided significant results in reducing the fever, rigor with chill, headache, bodyache, sweating, anorexia, weakness and cough. On comparison the patients treated with Siddharthakadi agada showed better results in controlling anorexia, headache and body ache. Peripheral smear test after seven days of treatment with agada was negative for all patients.<ref>Rimpal Virsodiya (2006): Effect of Siddharthakadi Agada in the management of Malaria (Jvara), Department of Kayachikitsa, IPGT&RA, Jamnagar.</ref>
#Powder of leaves and root of Melia AzedaractaLinn.(mahanimba) were administered to experimental models of induced pyrexia in albino rats. Root powder showed better antipyretic effect than leaf powder.<ref>Shweta R Vekariya (2015): Pharmacological evaluation of Mahanimba (Melia Azedarach Linn.) with special reference to analgesic and antipyrectic activities. Department of Dravyaguna Vigyan, IPGT&RA, Jamnagar.</ref>
#Powder of leaves and root of Melia Azedaracta Linn.(mahanimba) were administered to experimental models of induced pyrexia in albino rats. Root powder showed better antipyretic effect than leaf powder.<ref>Shweta R Vekariya (2015): Pharmacological evaluation of Mahanimba (Melia Azedarach Linn.) with special reference to analgesic and antipyrectic activities. Department of Dravyaguna Vigyan, IPGT&RA, Jamnagar.</ref>
=Mechanism of action of antipyretic medicines=
=Mechanism of action of antipyretic medicines=