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2.Filling the urinary bladder or maintaining fluid volume in bladder.[Su. Sa. [[Sutra Sthana]] 15/5], [A.Hr. [[Sutra Sthana]] 11/5]

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The overall function of urinary system is to filter approximately 200 liters of fluid a day from blood. It excretes toxins, metabolic waste products, and excess ions through urine.Essential substances in the blood are reabsorbed.Apart from this, plasma osmolarity and acid-base metabolism is regulated.

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The overall function of urinary system is to filter approximately 200 liters of fluid a day from blood. It excretes toxins, metabolic waste products, and excess ions through urine.Essential substances in the blood are reabsorbed.Apart from this, plasma osmolarity and acid-base metabolism is regulated.<ref>Ogobuiro I, Tuma F. Physiology, Renal. [Updated 2020 Aug 29]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK538339/</ref>

==Channels carrying urine (mutravaha srotas)==

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==Urine Examination (mutra pareeksha)==

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Hippocrates (400 BC), in his text De Urinis Theophilus, mentioned the use of urine to interpret human body functioning, urine was mainly used as a means for prognosis and prediction of outcomes of illness. Theophilus (700 AD) treated uroscopy in a sophisticated objective manner, and contributed to the birth of medieval medical studies.

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Hippocrates (400 BC), in his text De Urinis Theophilus, mentioned the use of urine to interpret human body functioning, urine was mainly used as a means for prognosis and prediction of outcomes of illness. Theophilus (700 AD) treated uroscopy in a sophisticated objective manner, and contributed to the birth of medieval medical studies.<ref>Kouba E, Wallen EM, Pruthi RS. Uroscopy by Hippocrates and Theophilus: prognosis versus diagnosis. J Urol. 2007 Jan;177(1):50-2. doi: 10.1016/j.juro.2006.08.111. PMID: 17161998.</ref>

The routine urine examination (urinalysis) is a useful tool for determining the health status as well as many diseases especially related to urinary system.

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The examination includes following:

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The examination includes the following:<ref>Baig, Atif. (2011). Biochemical Composition of Normal Urine. Nature Precedings. 10.1038/npre.2011.6595.1.</ref>

a) Physical examination: in terms of volume, colour, appearance, odour, specific gravity.

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== Current Researches==

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*Urine is a very useful and widely used bio fluid for research purpose in metabolomics. An online database containing the complete set of 2651 confirmed human urine metabolite species, their structures (3079 in total), concentrations, related literature references and links to their known disease associations are freely available now.

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*Urine is a very useful and widely used bio fluid for research purpose in metabolomics. An online database containing the complete set of 2651 confirmed human urine metabolite species, their structures (3079 in total), concentrations, related literature references and links to their known disease associations are freely available now.<ref>Souhaila Bouatra et al, The Human Urine Metabolome, Plos One, September 2013 | Volume 8 | Issue 9 | e73076.</ref>

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*Now a days, artificial urine is prepared as similar to the chemical composition of human urine and has been used with many advantages for research and educational purpose.

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*Now a days, artificial urine is prepared as similar to the chemical composition of human urine and has been used with many advantages for research and educational purpose.<ref>Sarigul N, Korkmaz F, Kurultak İ. A New Artificial Urine Protocol to Better Imitate Human Urine. Sci Rep. 2019;9(1):20159. Published 2019 Dec 27. doi:10.1038/s41598-019-56693-4</ref>

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*In the field of research in Ayurveda, many studies are being conducted to standardize the techniques and various parameters of oil drop examination (Taila bindu pareeksha) of urine to extend it in terms of modern parameters and make use of it as a cost-effective method for diagnostic and prognostic aspects.

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*In the field of research in Ayurveda, many studies are being conducted to standardize the techniques and various parameters of oil drop examination (Taila bindu pareeksha) of urine to extend it in terms of modern parameters and make use of it as a cost-effective method for diagnostic and prognostic aspects.<ref>Kar AC, Sharma R, Panda BK, Singh VP. A study on the method of Taila Bindu Pariksha (oil drop test). Ayu. 2012;33(3):396-401. doi:10.4103/0974-8520.108851</ref> <ref>Sangu PK, Kumar VM, Shekhar MS, Chagam MK, Goli PP, Tirupati PK. A study on Tailabindu pariksha - An ancient Ayurvedic method of urine examination as a diagnostic and prognostic tool. Ayu. 2011;32(1):76-81. doi:10.4103/0974-8520.85735</ref>

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*It is being studied and used in clinical practice in the prognostic aspects of various disorders including malignancy.

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*It is being studied and used in clinical practice in the prognostic aspects of various disorders including malignancy.<ref>Kachare KB, Kar AC. Assessment of prognostic aspects of cancer by Taila Bindu Pariksha. Ayu. 2015;36(1):18-22. doi:10.4103/0974-8520.169003.</ref>

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*The mechanism of urine formation in the intestine and its connection with the renal system may provide substantial solutions in management of chronic kidney diseases. A recent experimental study conducted on rats with impaired renal function (induced by intragastric administration of adenine), has proven that intestinal tract had excretory function compensative for renal function. A study showed good improvement in microalbuminuria in diabetic patients after therapeutic enema (basti) with ayurvedic formulation of Tribulus terrestris (gokshura) and Borrhavia diffusa (punarnava). Another study showed significant improvement in cases of chronic renal failure. The relation of gut and kidneys can be explored more to find better management solutions for kidney diseases.

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*The mechanism of urine formation in the intestine and its connection with the renal system may provide substantial solutions in management of chronic kidney diseases. A recent experimental study conducted on rats with impaired renal function (induced by intragastric administration of adenine), has proven that intestinal tract had excretory function compensative for renal function.<ref>Yu Yun et al, Excretory Function of Intestinal Tract Enhanced in Kidney Impaired Rats Caused by Adenine, The Scientific World Journal ,Volume 2016, Article ID 2695718, https://doi.org/10.1155/2016/2695718.</ref>

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A study showed good improvement in microalbuminuria in diabetic patients after therapeutic enema (basti) with ayurvedic formulation of Tribulus terrestris (gokshura) and Borrhavia diffusa (punarnava).<ref>Ramteke RS, Thakar AB, Trivedi AH, Patil PD. Clinical efficacy of Gokshura-Punarnava Basti in the management of microalbuminuria in diabetes mellitus. AYU [serial online] 2012 [cited 2020 Dec 23];33:537-41. Available from: https://www.ayujournal.org/text.asp?2012/33/4/537/110535</ref> Another study showed significant improvement in cases of chronic renal failure.<ref>Patel MV, Gupta S N, Patel NG. Effects of Ayurvedic treatment on 100 patients of chronic renal failure (other than diabetic nephropathy). AYU [serial online] 2011 [cited 2020 Dec 23];32:483-6. Available from: https://www.ayujournal.org/text.asp?2011/32/4/483/96120</ref> The relation of gut and kidneys can be explored more to find better management solutions for kidney diseases.

==Related theses works==

Anaghas

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