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=== Etiological factors ===

=== Etiological factors ===

''Tridosha prakopa nidana'' mentioned by Vagbhata comprises of ''sankirna, ajirna, vishama, viruddha, adhyashana, vyapanna-madya, putishushkakrishaamisha'' etc. (Ashtangahridaya Nidanasthana 1/19, 20). Consuming foods having different ''gunas'' altogether (''sankirna''), practice of food and regimen which are antagonistic to the body’s state and stage (''viruddha''), consuming food before the previous one gets digested (''adhyashana'') and repeated development of indigestion (''ajirna'') explained in the aetiology are direct causes for ''tridosha prakopa''. Regular habituation of ''viruddha, adhyashana'' and ''ajirna'' causes accumulation of toxic metabolites in ''rasa dhatu''. These toxic metabolites avert proper utilization of ''rasadhatu'' and elicit ''tridosha prakopa'', which carry untransformed ''rasadhatu'' to ''amashaya''. This ''rasadhatu'', which is having attributes of ''kapha'' is taken to ''amashaya'' to get metabolized (digested) by ''kaphagni'' present there. Thus ''ama rasadhatu'' is a condition of ''koshtha''. If ''amarasadhatu'' fails to get digested, it interacts and combines with elicited ''tridosha'' to become one which is designated as ''saama(tri)dosha''. Thus ''tridosha prakopa'' occurs indirectly also by the toxic metabolites developing due to incompatible practices. As fat predominant circumstance paves for the initiation of pathogenesis of this disease, kapha gains more strength than the other two doshas. Kapha or saamakapha subdues pitta (Abhibhuya itaram dosham uru cet pratipadyate – Ashtangahridaya Nidana 15/48). In medodushtija conditions all the channels will be obstructed by medas (Sushruta Sutra 15/32). If the subject happens to indulge in overexertion, jerks, day-time sleep or awakening in night, the pathogenic factor (saama-kapha-vata) along with medas from koshdha (rasa-dhatu) moves to lower limbs and affects sakthi (lower limbs). Causes for the movement of doshas from koshdha to other rogamargas include overexertion, uncontrolled digestive or metabolic activity, unwholesome practice or vyana hyperactivity. Aavarana (obstruction of the movement of vata) pathogenesis also takes place at the siras supplying lowerlimbs. Prakupita dosha (dosha which gets aggravated by extrinsic causes and are not innately present in the body) is regarded as vata and innate intrinsic dosha is regarded as vayu (prana-udana-vyana-samana-apana) in Classics. Though both vata and vayu can get avarana, here medasaavrita vata (obstruction to vata which got aggravated by extrinsic causes by vitiated medas) takes place. Hence urusthambha has a synonym aadhyavata (Ashtangahridaya Nidana 15), which actually is a synonym of medasaavrita-vata (aadhyavata iti jneyassa kricchro medasaavrite – Madhav Nidan). The movement of vata as well as the active movement of lower limbs (performed by vyana vayu) will be obstructed by the medas and also made motionlessness (mudha-vata) by saamata. Hence the disease got the name by the samsthaana (sign), immobility of uru (urusthambha) caused by medas and ama.

''Tridosha prakopa nidana'' mentioned by Vagbhata comprises of ''sankirna, ajirna, vishama, viruddha, adhyashana, vyapanna-madya, putishushkakrishaamisha'' etc. <ref>Vagbhata. Nidana Sthana, Cha.1 Sarvaroga Nidana  Adhyaya verse 19,20. In: Harishastri Paradkar Vaidya, Editors. Ashtanga Hridayam. 1st ed. Varanasi: Krishnadas Academy;2000.p.4.</ref>. Consuming foods having different ''gunas'' altogether (''sankirna''), practice of food and regimen which are antagonistic to the body’s state and stage (''viruddha''), consuming food before the previous one gets digested (''adhyashana'') and repeated development of indigestion (''ajirna'') explained in the aetiology are direct causes for ''tridosha prakopa''. Regular habituation of ''viruddha, adhyashana'' and ''ajirna'' causes accumulation of toxic metabolites in ''rasa dhatu''. These toxic metabolites avert proper utilization of ''rasadhatu'' and elicit ''tridosha prakopa'', which carry untransformed ''rasadhatu'' to ''amashaya''. This ''rasadhatu'', which is having attributes of ''kapha'' is taken to ''amashaya'' to get metabolized (digested) by ''kaphagni'' present there. Thus ''ama rasadhatu'' is a condition of ''koshtha''. If ''amarasadhatu'' fails to get digested, it interacts and combines with elicited ''tridosha'' to become one which is designated as ''saama(tri)dosha''. Thus ''tridosha prakopa'' occurs indirectly also by the toxic metabolites developing due to incompatible practices. As fat predominant circumstance paves for the initiation of pathogenesis of this disease, kapha gains more strength than the other two doshas. Kapha or saamakapha subdues pitta.<ref>Vagbhata. Nidana Sthana, Cha.15, Vatavyadhi Nidana Adhyaya verse 48. In: Harishastri Paradkar Vaidya, Editors. Ashtanga Hridayam. 1st ed. Varanasi: Krishnadas Academy;2000.p.4.</ref> In medodushtija conditions all the channels will be obstructed by medas. <ref>Sushruta. Sutra Sthana, Cha.15 Doshadhatumalakshayavruddhivijnaneeyam  Adhyaya verse 32. In: Jadavaji Trikamji Aacharya, Editors. Sushruta Samhita. 8th ed. Varanasi: Chaukhambha Orientalia;2005. p.1.</ref>. If the subject happens to indulge in overexertion, jerks, day-time sleep or awakening in night, the pathogenic factor (saama-kapha-vata) along with medas from koshdha (rasa-dhatu) moves to lower limbs and affects sakthi (lower limbs). Causes for the movement of doshas from koshdha to other rogamargas include overexertion, uncontrolled digestive or metabolic activity, unwholesome practice or vyana hyperactivity. Aavarana (obstruction of the movement of vata) pathogenesis also takes place at the siras supplying lowerlimbs. Prakupita dosha (dosha which gets aggravated by extrinsic causes and are not innately present in the body) is regarded as vata and innate intrinsic dosha is regarded as vayu (prana-udana-vyana-samana-apana) in Classics. Though both vata and vayu can get avarana, here medasaavrita vata (obstruction to vata which got aggravated by extrinsic causes by vitiated medas) takes place. Hence urusthambha has a synonym aadhyavata (Ashtangahridaya Nidana 15), which actually is a synonym of medasaavrita-vata (aadhyavata iti jneyassa kricchro medasaavrite – Madhav Nidan). The movement of vata as well as the active movement of lower limbs (performed by vyana vayu) will be obstructed by the medas and also made motionlessness (mudha-vata) by saamata. Hence the disease got the name by the samsthaana (sign), immobility of uru (urusthambha) caused by medas and ama.

'''Table 1: Pathological factors involved in urustambha'''

'''Table 1: Pathological factors involved in urustambha'''