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Majja dhatu (view source)

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==Current researches ==

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• Replacement of red hematopoietic bone marrow with yellow adipocyte-rich marrow is a conserved physiological process among mammals.Several important molecular characteristics of bone marrow adipose tissue (BMAT) are distinct from the classical depots of white and brown fat tissue. This depot of fat has recently emerged as an active part of the bone marrow niche that exerts paracrine and endocrine functions thereby controlling osteogenesis and hematopoiesis.

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• Bone marrow-derived mesenchymal stem cells (BM-MSCs) have potential of differentiation and they secrete anti-inflammatory cytokines and growth factors which make them appropriate for cell therapy. A study conducted to evaluate the healing effect of BM-MSCs transplantation on germinal cells showed that the transplanted BM-MSCs could successfully induce spermatogenesis in seminiferous tubules of azoospermic hamster. Therefore, BM-MSCs can be an attractive candidate in cell transplantation of azoospermia.

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• Replacement of red hematopoietic bone marrow with yellow adipocyte-rich marrow is a conserved physiological process among mammals. Several important molecular characteristics of bone marrow adipose tissue (BMAT) are distinct from the classical depots of white and brown fat tissue. This depot of fat has recently emerged as an active part of the bone marrow niche that exerts paracrine and endocrine functions thereby controlling osteogenesis and hematopoiesis.

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• In a clinical study, it is observed that majja basti (therapeutic enema with bone marrow) along with oral intake of asthi shrinkhala(Cissus quadrangularis) ~~showencouraging~~ results in the management of osteoporosis (asthi-majjakshaya) and it also improves the general health of the patients.

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Further scope of research

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• Bone marrow-derived mesenchymal stem cells (BM-MSCs) have the potential of differentiation and they secrete anti-inflammatory cytokines and growth factors which make them appropriate for cell therapy. A study conducted to evaluate the healing effect of BM-MSCs transplantation on germinal cells showed that the transplanted BM-MSCs could successfully induce spermatogenesis in seminiferous tubules of azoospermic hamster. Therefore, BM-MSCs can be an attractive candidate in cell transplantation of azoospermia.

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Bone marrow is used in therapeutics as food and administration through enema. Studies are needed to evaluate effect of oral and per rectal administration of animal bone marrow (majja basti) in management of diseases of bone marrow. It can open a new window in the treatment of severe diseases like leukemia.

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• In a clinical study, it is observed that majja basti (therapeutic enema with bone marrow) along with oral intake of asthi shrinkhala(Cissus quadrangularis) shows encouraging results in the management of osteoporosis (asthi-majjakshaya) and it also improves the general health of the patients.

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'''Further scope of research'''

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Bone marrow is used in therapeutics as food and administration through enema. Studies are needed to evaluate the effect of oral and per rectal administration of animal bone marrow (majja basti) in the management of diseases of bone marrow. It can open a new window in the treatment of severe diseases like leukemia.

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===List of theses done===

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1.Ajay K Gupta (2010) Effect of majja basti&asthi shrinkhala in the management of osteoporosis w.s.r. to asthi-majja kshaya-A clinical study, department of panchakarma, IPGT &RA, Jamnagar.

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2.Saurabh R Bhuva(2012) A Comparative Study of Matra Basti and Brimhana Snehana by Asthishrinkhala Ghrita in the management of Asthi-Majja Kshaya w.s.r. to Osteopenia / Osteoporosis, department of panchakarma, IPGT &RA, Jamnagar.

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==More information ==

[[ Vividhashitapitiya Adhyaya]]

[[ Grahani Chikitsa]]

Anagha

600

edits