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== Sanskrit Text, Transliteration with English Translation ==
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Now we shall expound the chapter "Jeemutaka Kalpa" (The pharmaceutics of Jimutaka).Thus said Lord Atreya [1-2]
Note: Jeemutaka is Bristly luffa.
=== Synonyms and qualities ===
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''Jimutaka'' when administered with appropriate drugs cures diseases caused by all the three ''doshas''. It is useful in fever, dyspnea, hiccup and similar other disorders. [4]
''Jimutaka'' when administered with appropriate drugs cures diseases caused by all the three ''doshas''. It is useful in fever, dyspnea, hiccup and similar other disorders. [4]
=== Various Preparations ===
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The ghee prepared (extracted directly or processed according to the procedure of snehakalpana) from the milk boiled with Jimutaka should be cooked with decoction of madanaphala etc. It is regarded as an excellent recipe for emesis. [13]
The ghee prepared (extracted directly or processed according to the procedure of snehakalpana) from the milk boiled with Jimutaka should be cooked with decoction of madanaphala etc. It is regarded as an excellent recipe for emesis. [13]
=== Summary ===
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Thus ends the second chapter of kalpa sthana dealing with the “pharmaceutics of Jimutaka” compiled by Agnivesa, redacted by Charaka, and reconstructed by Dridhabala, as it was unavailable. [14-15]
Thus ends the second chapter of kalpa sthana dealing with the “pharmaceutics of Jimutaka” compiled by Agnivesa, redacted by Charaka, and reconstructed by Dridhabala, as it was unavailable. [14-15]
== Tattva Vimarsha (Fundamental Principles) ==
* Jeemutak is used as emetic herb in [[vamana]] (therapeutic emesis).
* Jeemutak is used as emetic herb in [[vamana]] (therapeutic emesis).
== Vidhi Vimarsha (Applied Inferences)==
Emetics should be administered with vehicles depending on ''dosha''. For example in ''pitta'' dominant conditions drugs are administered with milk, ''draksha, amalaka, parushaka'', etc., honey and ''gomutra'' are employed in ''kapha dosha'' and with ''sura'' (wine) and other fermented drinks, curd etc. in ''vata dosha''. Gangadhara described the use of ''jimutaka'' in kotha (urticaria) and he also commented that Hikkadi includes Kasa. Chakrapani specifically indicates that diseases which are due to urogatadosha should be considered under hikkadi.
Emetics should be administered with vehicles depending on ''dosha''. For example in ''pitta'' dominant conditions drugs are administered with milk, ''draksha, amalaka, parushaka'', etc., honey and ''gomutra'' are employed in ''kapha dosha'' and with ''sura'' (wine) and other fermented drinks, curd etc. in ''vata dosha''. Gangadhara described the use of ''jimutaka'' in kotha (urticaria) and he also commented that Hikkadi includes Kasa. Chakrapani specifically indicates that diseases which are due to urogatadosha should be considered under hikkadi.
The recipe with ''Jimutaka'' as nasal drops in the management of ''Kamala'' is very popular and has scientific validation. Its Emetic activity has also been revalidated. Being ''tiskanavamaka'' it can be used in ''Nanatmaja Kapha Vikara''. Though it sometimes may create hematemesis.
The recipe with ''Jimutaka'' as nasal drops in the management of ''Kamala'' is very popular and has scientific validation. Its Emetic activity has also been revalidated. Being ''tiskanavamaka'' it can be used in ''Nanatmaja Kapha Vikara''. Though it sometimes may create hematemesis.
== Researches ==
#Aqueous extract of fruits significantly lowered the serum bilirubin level in chlorpromazine – induced jaundice in rats[12]
#Aqueous extract of fruits significantly lowered the serum bilirubin level in chlorpromazine – induced jaundice in rats[12]
*Anti-cancer activity [19]
*Anti-cancer activity [19]
===Thrust areas of research ===
=== Reference ===
Thyroid disorders became common especially in female. Thyroid disorders especially hypothyroidism should be treated by giving Vamana with ''Jimutaka''. It can be used as emetic in de-addiction due to alcohol withdrawal syndrome due to its hepato protective activity.
=== Further reading ===
#Ram Karan Sharma and Vaidya Bhagwan Dash, Caraka Samhita, Vol VI, Kalpasthana, Chap 1, shlok no.7, edition 2nd 2005,Chaukhamba Sanskrit Series Office, Varanasi, pp. 6.
#Ram Karan Sharma and Vaidya Bhagwan Dash, Caraka Samhita, Vol VI, Kalpasthana, Chap 1, shlok no.7, edition 2nd 2005,Chaukhamba Sanskrit Series Office, Varanasi, pp. 6.
#Li-Hua Shang et al, LuffaechinataRoxb. Induces Human Colon Cancer Cell (HT-29) Death by Triggering the Mitochondrial Apoptosis Pathway, Molecules 2012, 17, 5780-5794; doi:10.3390/molecules17055780.
#Li-Hua Shang et al, LuffaechinataRoxb. Induces Human Colon Cancer Cell (HT-29) Death by Triggering the Mitochondrial Apoptosis Pathway, Molecules 2012, 17, 5780-5794; doi:10.3390/molecules17055780.
== References ==
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