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2. '''Circulating component (poshakameda dhatu):''' This form is circulated with nutrient fluid or plasma ([[rasa dhatu]]) and blood([[rakta]]). It is free and unbound (abaddhamedas). This provides lubrication and unctuousness wherever needed. This form is vitiated in the pathogenesis of obstinate urinary disorders including diabetes (prameha) [Cha.Sa.[[Nidana Sthana]] 4/7]
2. '''Circulating component (poshakameda dhatu):''' This form is circulated with nutrient fluid or plasma ([[rasa dhatu]]) and blood([[rakta]]). It is free and unbound (abaddhamedas). This provides lubrication and unctuousness wherever needed. This form is vitiated in the pathogenesis of obstinate urinary disorders including diabetes (prameha) [Cha.Sa.[[Nidana Sthana]] 4/7]
===Metabolic by-products and waste products (Upadhatu and mala)===
During the process of metabolism and formation of meda dhatu, ligaments (snayu) are formed as the metabolic byproducts (upadhatu). [Cha. Sa. [[Chikitsa Sthana]] 15/17]. Sweat and sebum are formed during this process as waste products (mala). [Cha.Sa. [[Chikitsa Sthana]] 15/18].
During the process of metabolism and formation of meda dhatu, ligaments (snayu) are formed as the metabolic byproducts (upadhatu). [Cha. Sa. [[Chikitsa Sthana]] 15/17]. Sweat and sebum are formed during this process as waste products (mala). [Cha.Sa. [[Chikitsa Sthana]] 15/18].
===Quantity===
The total quantity of medadhatu is two anjali (personified measurement unit). The quantity of vasa is three anjali (personified measurement unit). One Anjali is equal to the quantity that can be filled in a space formed from joining one’s palms together. [Cha. Sa. [[Sharira Sthana]] 7/15]
The total quantity of medadhatu is two anjali (personified measurement unit). The quantity of vasa is three anjali (personified measurement unit). One Anjali is equal to the quantity that can be filled in a space formed from joining one’s palms together. [Cha. Sa. [[Sharira Sthana]] 7/15]
===Time span===
The meda dhatu is formed on the 4th day from the nutrient fluid (ahara rasa). [Cha.Sa. [[Chikitsa Sthana]] 15/20-21] However, Sushruta opines that the meda dhatu is formed in fifteen days (a time span of 9045 kala). [Su. Sa. Sutra Sthana 14/14]
The meda dhatu is formed on the 4th day from the nutrient fluid (ahara rasa). [Cha.Sa. [[Chikitsa Sthana]] 15/20-21] However, Sushruta opines that the meda dhatu is formed in fifteen days (a time span of 9045 kala). [Su. Sa. Sutra Sthana 14/14]
===Characteristics of best quality of adipose tissue (medasara )===
The person endowed with best quality of meda dhatu has significant unctuousness specifically in complexion, voice, eyes, hair, skin hair, nails, teeth, lips, urine and feces. This indicates wealth, power, happiness, enjoyment, charity, simplicity and delicacy in dealings.[Cha.Sa.[[Vimana Sthana]] 8/106]
The person endowed with best quality of meda dhatu has significant unctuousness specifically in complexion, voice, eyes, hair, skin hair, nails, teeth, lips, urine and feces. This indicates wealth, power, happiness, enjoyment, charity, simplicity and delicacy in dealings.[Cha.Sa.[[Vimana Sthana]] 8/106]
==Physiological aspects: ==
==Physiological aspects ==
Channels of transportation and transformation of meda dhatu (medovahasrotas):
The channels of transportation and transformation of meda dhatu originate from the kidneys(vrikka) and omentum (vapavahana), [Cha. Sa. Vimana Sthana 5/8]Sushruta opines that they originated from pelvic region(kati) and kidneys(vrikka).[Su. Sa. ShariraSthana 9/12]Vagbhata added mamsa dhatu to the origin with kidneys (vrikka).[Ashtanga SangrahaShariraSthana 6/26]
===Channels of transportation and transformation of meda dhatu (medovahasrotas):===
Considering above opinions, the origin of meda dhatu can be considered in pelvic region, omentum and kidneys. The sites of origin are important for knowing the source of nourishment in diagnosis and treatment.
The channels of transportation and transformation of meda dhatu originate from the kidneys(vrikka) and omentum (vapavahana), [Cha. Sa. [[Vimana Sthana]] 5/8]
Layer of meda dhatu (medodharakala):
It is the layer of fat present in abdominal cavity, small bones and long bones. In abdominal cavity it is present in the form of visceral fats.
Sushruta opines that they originated from pelvic region(kati) and kidneys(vrikka).[Su. Sa. Sharira Sthana 9/12].
Meda dhatu presentin the long and big bones is known as marrow (majja).That presentinside the small bones is termed as red marrow (saraktameda). The unctuous portion of mamsa dhatu transforms into fat and is known as muscle fat (vasa). [Su. Sa. ShariraSthana 4/13]
Role of meda dhatu in embryonic development:
Vagbhata added mamsa dhatu to the origin with kidneys (vrikka).[Ashtanga SangrahaShariraSthana 6/26]
During embryogenesis, veins (sira) and ligaments (snayu) are formed from the unctuous portion of meda dhatu. The veins are formed after mild action of factors responsible for metabolism(agni)that makes them elastic and smooth. Ligaments(snayu) are formed after strong action of factors responsible for metabolism(agni) that makes them hard. [Su. Sa. ShariraSthana 4/29-30]
The kidneys (vrikka) are formed from unification of essence of blood tissue(rakta dhatu)and adipose tissue (meda dhatu).The testis(vrishana) are formed from unification of essence of adipose tissue (meda dhatu),muscle tissue (mamsa dhatu), blood tissue (rakta dhatu) and kaphadosha. [Su. Sa. ShariraSthana 4/31]
Considering the above opinions, the origin of meda dhatu can be considered in pelvic region, omentum and kidneys. The sites of origin are important for knowing the source of nourishment in diagnosis and treatment.
Meda dhatu is responsible for functions of lubrication(sneha),sweating (sweda), stability (dridhatwam) and nourishment of bone tissue(asthipushti). [Su. Sa. Sutra Sthana 15/5]
The following structures can be considered as components of the transportation and transformation system of meda dhatu.
===Layer of meda dhatu (medodharakala):===
It is the layer of fat present in the abdominal cavity, small bones and long bones. In the abdominal cavity, it is present in the form of visceral fats.
Meda dhatu present in the long and big bones is known as marrow (majja).That present inside the small bones is termed as red marrow (saraktameda). The unctuous portion of mamsa dhatu transforms into fat and is known as muscle fat (vasa). [Su. Sa. Sharira Sthana 4/13]
===Role of meda dhatu in embryonic development:===
During embryogenesis, veins (sira) and ligaments (snayu) are formed from the unctuous portion of meda dhatu. The veins are formed after mild action of factors responsible for metabolism([[agni]])that makes them elastic and smooth. Ligaments(snayu) are formed after the strong action of factors responsible for metabolism([[agni]]) that makes them hard. [Su. Sa. Sharira Sthana 4/29-30]
The kidneys (vrikka) are formed from the unification of the essence of blood tissue([[rakta dhatu]])and adipose tissue (meda dhatu).The testis(vrishana) are formed from the unification of the essence of adipose tissue (meda dhatu),muscle tissue ([[mamsa dhatu]]), blood tissue ([[rakta dhatu]]) and [[kapha dosha]]. [Su. Sa. Sharira Sthana 4/31]
==Functions==
Meda dhatu is responsible for functions of lubrication(sneha), sweating (sweda), stability (dridhatwam), and nourishment of bone tissue([[asthi]]pushti). [Su. Sa. Sutra Sthana 15/5]
==Importance in diagnosis: ==
==Importance in diagnosis: ==
===Causes of vitiation===
===Causes of vitiation===
The channels of transportation and transformation of meda dhatu (medovahasrotas) are affected by sedentary lifestyle including lack of physical exercise, daytime sleep, excessive consumption of fatty food and alcoholic drinks. [Cha. Sa. Vimana Sthana 5/16]
The channels of transportation and transformation of meda dhatu (medovahasrotas) are affected by the sedentary lifestyle including lack of physical exercise, daytime sleep, excessive consumption of fatty food, and alcoholic drinks. [Cha. Sa. [[Vimana Sthana]] 5/16]
===Abnormal states===
===Abnormal states===
The increase or decrease in quality and/or quantity of meda dhatu can lead to various abnormal conditions. The states can be assessed by following clinical features.
The increase or decrease in quality and/or quantity of meda dhatu can lead to various abnormal conditions. The states can be assessed by the following clinical features.
Decrease of meda dhatu:
Symptoms of decrease of meda dhatu are cracking sound in the joints, lassitude in eyes, exhaustion, decreased abdominal girth or thinning, splenomegaly, feeling of emptiness in joints. dryness and craving for fatty food and meat. [Cha. Sa. Sutra Sthana 17/66], [Su. Sa. Sutra Sthana 15/9]
====Decrease of meda dhatu:====
Increase of meda dhatu:
Symptoms of decrease of meda dhatu are cracking sound in the joints, lassitude in eyes, exhaustion, decreased abdominal girth or thinning, splenomegaly, feeling of emptiness in joints. dryness and craving for fatty food and meat. [Cha. Sa. [[Sutra Sthana]] 17/66], [Su. Sa. Sutra Sthana 15/9]
====Increase of meda dhatu:====
The increase in meda dhatu can be observed by unctuousness of body,increased abdominal girth (abdominal obesity), increased size of flanks,cough, dyspnoeaand bad body odour. [Su. Sa. Sutra Sthana 15/14]
The increase in meda dhatu can be observed by unctuousness of body,increased abdominal girth (abdominal obesity), increased size of flanks,cough, dyspnoeaand bad body odour. [Su. Sa. Sutra Sthana 15/14]
Clinical features of vitiation:
• Premonitory symptoms of obstinate urinary disorders including diabetes mellitus (prameha)and signs of eight undesirable types of physical constitutions are observed due to vitiation of channels of transportation and transformation of meda dhatu. [Cha. Sa. Sutra Sthana 28/15]
===Clinical features of vitiation:===
• The premonitory symptoms of obstinate urinary disorders including diabetes mellitus (prameha) include excess sweating, body odor, flabbiness of the body, desire for constantly lying on the bed, sitting, sleeping and leading an easy life, a feeling as if the cardiac region is covered with extraneous material, exudation of excreta from eyes, tongue and ears, corpulence of the body, excessive growth of hair and nails, liking for cold things, dryness of throat and palate, sweet taste in the mouth, burning sensation in hands and legs and swarming of ants on the urine. [Cha.Sa.ChikitsaSthana 6/13-14]
• The signs of eight undesirable physical constitutions include too tall, too short, too hairy, hairless, too dark, too light (complexion), too obese and too lean body statures. [Cha, Sa.Sutra Sthana 21/3]
• Premonitory symptoms of obstinate urinary disorders including diabetes mellitus (prameha)and signs of eight undesirable types of physical constitutions are observed due to vitiation of channels of transportation and transformation of meda dhatu. [Cha. Sa. [[Sutra Sthana]] 28/15]
• When there is injury to channels of transportation and transformation of meda dhatu(medovahasrotas), the symptoms like excessive sweating, unctuousness of body, dryness of the palate, thick or hard swelling and severe thirst are observed. [Su. Sa.ShariraSthana 9/12]
Role of meda dhatu as vitiated factor in diseases:
• The premonitory symptoms of obstinate urinary disorders including diabetes mellitus (prameha) include excess sweating, body odor, flabbiness of the body, desire for constantly lying on the bed, sitting, sleeping and leading an easy life, a feeling as if the cardiac region is covered with extraneous material, exudation of excreta from eyes, tongue and ears, corpulence of the body, excessive growth of hair and nails, liking for cold things, dryness of throat and palate, sweet taste in the mouth, burning sensation in hands and legs and swarming of ants on the urine. [Cha.Sa.[[Chikitsa Sthana]] 6/13-14]
Meda dhatu is involved in the pathogenesis of following diseases:
• Obstinate urinary diseases including diabetes (Prameha)() [Cha. Sa. NidanaSthana 4/8],
• The signs of eight undesirable physical constitutions include too tall, too short, too hairy, hairless, too dark, too light (complexion), too obese and too lean body statures. [Cha, Sa.[[Sutra Sthana]] 21/3]
• vitiligo (Shwitra) [Cha. Sa. ChikitsaSthana 7/174]
• swelling (Shotha) [Cha. Sa. ChikitsaSthana 12/94],
• When there is injury to channels of transportation and transformation of meda dhatu(medovahasrotas), the symptoms like excessive sweating, unctuousness of body, dryness of the palate, thick or hard swelling and severe thirst are observed. [Su. Sa.Sharira Sthana 9/12]
• Anaemia(Pandu)[Cha.Sa. ChikitsaSthana 16/6],
• Disorders of thigh and hip (Urusthambha) [Cha. Sa. ChikitsaSthana 27/14].
===Role of meda dhatu as vitiated factor in diseases:===
• Obesity (Sthaulya)[Cha. Sa. Sutra Sthana 21/5-8].
• Vitiated dosha located in the channels of transport of medadhatu or medovahasrotascause quaternary fever (chaturthakajwara).[Cha. Sa. ChikitsaSthana 3/66]
Meda dhatu is involved in the pathogenesis of the following diseases:
• The clinical features of fever due to vitiation of meda dhatu by pitta dosha (medadhatugatajwara) are excessive sweating, thirst, incoherent speech, frequent emesis, inability to tolerate own body odor, wet feeling in the body and anorexia. [Cha. Sa. ChikitsaSthana 3/79].
• When vitiated vata is located in mamsa and meda dhatu, it manifestsproduces symptoms like heaviness of body, pricking pain and as if beaten by a strong rod or fist cuff and painful severe fatigue. [Cha. Sa. ChikitsaSthana 28/32].
• Obstinate urinary diseases including diabetes (Prameha)[Cha. Sa. [[Nidana Sthana]] 4/8]
• When the vata is occluded in the meda dhatu, it causes movable, smooth, soft, cold swellings in the body, and anorexia. This condition is known as ‘adhyavata’ and is difficult to cure. [Cha. Sa. ChikitsaSthana 28/66].
• Obesity (Sthaulya) is defined as excessive increase of meda and mamsa dhatu in the regions of buttocks, abdomen, and breasts. This leads to flabby or pendulous appearance the person suffers from deficient metabolism and energy. The pathogenesis of obesity begins with the obstruction of body channels by medas leading to excess deposition of fats. It causes severe diseases resulting in rapid deterioration of life. [Cha. Sa. Sutra Sthana 21/5-9].
• vitiligo (Shwitra) [Cha. Sa. [[Chikitsa Sthana]] 7/174]
==Importance of concept in preservation of health and prevention: ==
Meda dhatu provides unctuousness to all body components. Unctuousness is essential property of essence of all seven dhatu (oja). It is related to vitality and immunity of body. [Cha.Sa. ChikitsaSthana 24/31] The unctuous portion (sneha) carries functions like lubrication, providing moisture, smoothening, unction, fluidity, and ooziness. [Cha.Sa.Sutra Sthana 22/11] These are importantin various physiological processes and functions of body.
• swelling (Shotha) [Cha. Sa. [[Chikitsa Sthana]] 12/94]
• Anaemia(Pandu)[Cha.Sa. [[Chikitsa Sthana]] 16/6]
• Disorders of thigh and hip (Urusthambha) [Cha. Sa. [[Chikitsa Sthana]] 27/14]
• Obesity (Sthaulya)[Cha. Sa. [[Sutra Sthana]] 21/5-8]
• Vitiated dosha located in the channels of transport of medadhatu (medovahasrotas)cause quaternary fever (chaturthaka jwara).[Cha. Sa. [[Chikitsa Sthana]] 3/66]
• The clinical features of fever due to vitiation of meda dhatu by [[pitta dosha]] (medadhatugata jwara) are excessive sweating, thirst, incoherent speech, frequent emesis, inability to tolerate own body odor, wet feeling in the body and anorexia. [Cha. Sa. [[Chikitsa Sthana]] 3/79].
• When vitiated vata is located in [[mamsa]] and meda dhatu, it manifests by producing symptoms like heaviness of the body, pricking pain, and as if beaten by a strong rod or fist cuff and painful severe fatigue. [Cha. Sa. [[Chikitsa Sthana]] 28/32].
• When the [[vata]] is occluded in the meda dhatu, it causes movable, smooth, soft, cold swellings in the body, and anorexia. This condition is known as ‘adhyavata’ and is difficult to cure. [Cha. Sa. [[Chikitsa Sthana]] 28/66].
• Obesity (Sthaulya) is defined as an excessive increase of meda and [[mamsa dhatu]] in the regions of buttocks, abdomen, and breasts. This leads to flabby or pendulous appearance the person suffers from deficient metabolism and energy. The pathogenesis of obesity begins with the obstruction of body channels by medas leading to excess deposition of fats. It causes severe diseases resulting in rapid deterioration of life. [Cha. Sa. [[Sutra Sthana]] 21/5-9].
==Importance of concept in the preservation of health and prevention: ==
Meda dhatu provides unctuousness to all body components. Unctuousness is the essential property of the essence of all seven [[dhatu]] ([[ojas]]). It is related to vitality and immunity of the body. [Cha.Sa. [[Chikitsa Sthana]] 24/31] The unctuous portion (sneha) carries functions like lubrication, providing moisture, smoothening, unction, fluidity, and ooziness. [Cha.Sa.[[Sutra Sthana]] 22/11] These are important in various physiological processes and functions of the body.
==Management: ==
==Management: ==
• Nourishing therapy (brimhana) and oleation therapy (snehana) are indicated in conditions of decrease of meda dhatu. Drying therapy (rukshana)and scraping therapy (lekhana) are indicated in conditions of increase in meda dhatu. [Cha.Sa.Sutra Sthana22]
• Nourishing therapy (brimhana) and oleation therapy (snehana) are indicated in conditions of decrease of meda dhatu. Drying therapy (rukshana)and scraping therapy (lekhana) are indicated in conditions of increase in meda dhatu. [Cha.Sa.[[Sutra Sthana]]22]
• Food and drinks that alleviate vatadoshaand reduce kaphadosha and meda dhatu (fat),
• Therapeutic enema processed with drugs of sharply acting, dryand hot properties,
The management of diseases due to vitiation of medadhatu includes following measures: [Cha. Sa. [[Sutra Sthana]] 21/21-22]
• Drypowder massage (udwartana),
• Use of guduchi (TinosporacordifoliaMiers), musta (CyperusrotundusLinn), triphala (combination of Haritaki (Terminalia chebula Linn), bibhitaki(Terminalia belericaRoxb) and amalaki (Emblica officinalis Gaertn)), takrarishta (a fermented medicinal preparation of buttermilk) and honey .
• Food and drinks that alleviate vata dosha and reduce kapha dosha and meda dhatu (fat),
• The condition of fever due to pitta dosha in mamsa dhatu and meda dhatu is managed by therapeutic purgation (virechana) and fasting (upavasa). [Cha. Sa. Chikitsa Sthana3/316].
• The treatment measures for vata located in meda dhatu are therapeutic purgation (virechana), evacuative enema(basti) and palliative measures(shamana). [Cha. Sa. ChikitsaSthana 28/93].
• Therapeutic enema processed with drugs of sharply acting, dry and hot properties,
• Dry powder massage (udwartana),
• Use of guduchi (Tinospora cordifolia Miers), musta (Cyperusrotundus Linn), triphala (combination of Haritaki (Terminalia chebula Linn), bibhitaki(Terminalia belerica Roxb) and amalaki (Emblica officinalis Gaertn)), takrarishta (a fermented medicinal preparation of buttermilk) and honey.
• The condition of fever due to pitta dosha in [[mamsa dhatu]] and meda dhatu is managed by therapeutic purgation ([[virechana]]) and fasting (upavasa). [Cha. Sa. [[Chikitsa Sthana]] 3/316].
• The treatment measures for vata located in meda dhatu are therapeutic purgation ([[virechana]]), evacuative enema([[basti]]) and palliative measures(shamana). [Cha. Sa. [[Chikitsa Sthana]] 28/93].
==Contemporary approach: ==
==Contemporary approach: ==
• In conventional physiology, concept of meda dhatu is perceived in view of adipose tissue, fats and lipids. Fat is found primarily as a continuous layer or as a deposition on membranes such as mesenteries or greater omentum. It is usually found around kidneys helping to hold them in place around the intestine and furrows of the heart. Fat is found in marrows of long bones also.
• In conventional physiology, the concept of meda dhatu is perceived in view of adipose tissue, fats, and lipids. Fat is found primarily as a continuous layer or as a deposition on membranes such as mesenteries or greater omentum. It is usually found around kidneys helping to hold them in place around the intestine and furrows of the heart. Fat is found in marrows of long bones also.
===Origin and formation:===
Adipose tissue is a loose connective tissue including adipocytes, fibroblasts, vascular endothelial cells, and some immune cells.
Adipose tissue is a loose connective tissue including adipocytes, fibroblasts, vascular endothelial cells, and some immune cells.
Adipocytes, or lipocytes or fat cells, primarily compose adipose tissue and store fat as energy. Adipocytes are derived from mesenchymal stem cells through adipogenesis.
Adipocytes, or lipocytes or fat cells, primarily compose adipose tissue and store fat as energy. Adipocytes are derived from mesenchymal stem cells through adipogenesis.
There are two types of adipose tissue, white adipose tissue (WAT) and brown adipose tissue (BAT), which are also known as white and brown fat, respectively, and comprise two types of fat cells.
There are two types of adipose tissue, white adipose tissue (WAT) and brown adipose tissue (BAT), which are also known as white and brown fat, respectively, and comprise two types of fat cells.
The WAT carries out functions of storage of fat, whereas BAT is involved in thermogenesis.
The WAT carries out functions of storage of fat, whereas BAT is involved in thermogenesis.
The third but poorly understood Marrow fat cells (unilocular cells) are also derived from mesenchymal stem cells. These cellsexpand in states of low bone density but additionally expands in the setting of obesity.
• Embryonic development:
The third but poorly understood marrowfat cells (unilocular cells) are also derived from mesenchymal stem cells. These cells expand in states of low bone density but additionally expands in the setting of obesity.
Mesenchymal stem cells can differentiate into adipocytes, connective tissue, muscle or bone. The fibroblast are pre adipocytes that can differentiate to form adipocytes. Connective tissues are originated from mesoderm during embryogenesis. The development of adipose tissue starts in 14th week of gestation in buccal pad.6
• Quantity and measurement:
• '''Embryonic development:'''
The total weight of fat in an average human adult measuresabout 13.5 kg. There are 30 billion fat cells. In case of excess weight gain, the fat cells show fourfold increase in size before dividing and increasing the absolute number of fat cells present.
• Functions:
Mesenchymal stem cells can differentiate into adipocytes, connective tissue, muscle, or bone. The fibroblast are preadipocytes that can differentiate to form adipocytes. Connective tissues are originated from mesoderm during embryogenesis. The development of adipose tissue starts in 14th week of gestation in buccal pad.6
Storage of fat:
The fat is stored in body for energy in case of starvation. The white fat cells store fat in a semi-liquid state. It is composed primarily of triglycerides and cholesteryl ester. White fat cells secrete many proteins acting as adipokines such as resistin, adiponectin, leptin and apelin.
• '''Quantity and measurement:'''
Generation of heat:
The total weight of fat in an average human adult measures about 13.5 kg. There are 30 billion fat cells. In case of excess weight gain, the fat cells show a fourfold increase in size before dividing and increasing the absolute number of fat cells present.
• '''Functions:'''
'''Storage of fat:'''
The fat is stored in the body for energy in case of starvation. The white fat cells store fat in a semi-liquid state. It is composed primarily of triglycerides and cholesteryl ester. White fat cells secrete many proteins acting as adipokines such as resistin, adiponectin, leptin and apelin.
'''Generation of heat:'''
The brown color in the brown fat cells comes from the large quantity of mitochondria. Therefore, the brown fat, also known as "baby fat," is used to generate heat.11
The brown color in the brown fat cells comes from the large quantity of mitochondria. Therefore, the brown fat, also known as "baby fat," is used to generate heat.11
Adaptation:
The fat cells tend to increase in size to store more fat in case needed.This expansion of fat mass leads to obesity.
'''Adaptation:'''
Investigations:
The fat cells tend to increase in size to store more fat in case needed. This expansion of fat mass leads to obesity.
'''Investigations:'''
The levels of meda dhatu can be investigated through various assessment parameters like:
The levels of meda dhatu can be investigated through various assessment parameters like:
1. Body mass index
1. Body mass index
2. Waist: hip ratio
2. Waist: hip ratio
3. Distribution of fat like measurement of visceral fat, muscle fats through body fat monitor
3. Distribution of fat like measurement of visceral fat, muscle fats through body fat monitor
4. Estimation of total Cholesterol, triglyceride, HDL (high density lipoprotein), LDL (low density lipoprotein) and VLDL Cholesterol (very low-density lipoprotein)
4. Estimation of total cholesterol, triglyceride, HDL (high density lipoprotein), LDL (low density lipoprotein) and VLDL Cholesterol (very low-density lipoprotein)
5. Serum insulin
5. Serum insulin
Role of adipocytes in causing obesity and diabetes:
From the above description, it is clear that meda dhatu is responsible for obesity (sthaulya)due to excess nourishment. The vitiation of channels of transportation and transformation ofmeda dhatu(medavahasrotasa) leads to obstinate urinary disorders including diabetes(prameha).
'''Role of adipocytes in causing obesity and diabetes:'''
Excess nutrition leads to expansion of fat mass and increase in size of adipocytes (hypertrophy). This leads to obesity. In the fat cells of obese individuals, there is increased production of metabolism modulators, such as glycerol, hormones, macrophage stimulating chemokines, and pro-inflammatory cytokines, leading to the development of insulin resistance. Insulin plays major role in fat production in adipocytes, synthesis of unsaturated fatty acids and stimulating lipogenesis. It also play role in uptake of glucose by muscles. The malfunctioning of insulin in turn leads to diabetes.
From the above description, it is clear that meda dhatu is responsible for obesity (sthaulya)due to excess nourishment. The vitiation of channels of transportation and transformation of meda dhatu(medavahasrotasa) leads to obstinate urinary disorders including diabetes(prameha).
This pathophysiology can be linked as follows:
Excess nutrition leads to the expansion of fat mass and an increase in the size of adipocytes (hypertrophy). This leads to obesity. In the fat cells of obese individuals, there is increased production of metabolism modulators, such as glycerol, hormones, macrophage stimulating chemokines, and pro-inflammatory cytokines, leading to the development of insulin resistance. Insulin plays a major role in fat production in adipocytes, synthesis of unsaturated fatty acids, and stimulating lipogenesis. It also plays a role in the uptake of glucose by muscles. The malfunctioning of insulin in turn leads to diabetes.
==Current researches: ==
==Current researches: ==
• An observational study assessing the qualities of excellence of medadhatu(sarata) in 60 individualsshowedsignificantlypositive relationshipwith values of lipids. The data showed that persons showing excellent qualities of meda dhatu have normal to high values of HDL (high density lipoproteins), comparatively low values of LDL (low density lipoproteins) and serum cholesterol.
• An observational study assessing the qualities of excellence of medadhatu(sarata) in 60 individuals showed significantly positive relationship with values of lipids. The data showed that persons showing excellent qualities of meda dhatu have normal to high values of HDL (high-density lipoproteins), comparatively low values of LDL (low-density lipoproteins), and serum cholesterol.
===List of theses ===
===List of theses ===
Very few research workshave been carried out on fundamental approach towards concept of meda dhatu.
Prameha (obstinate urinary disorders including diabetes) and sthaulya (obesity) are two most prevalent disorders observed in society. Hence the clinical research in relation to meda dhatu is mostly focused on these two disorders and effect of Ayurveda therapies in management. Hyperlipidaemia and dyslipidaemia are two other disorders related to meda dhatu.
Very few research works have been carried out on fundamental approach towards the concept of meda dhatu.
Prameha (obstinate urinary disorders including diabetes) and sthaulya (obesity) are two most prevalent disorders observed in society. Hence the clinical research in relation to meda dhatu is mostly focused on these two disorders and the effect of Ayurveda therapies in their management.
Hyperlipidemia and dyslipidemia are two other disorders related to meda dhatu.
1.Upadhyay Vashudev J (2001) : Medo-Dhatvagni ka SthaulyaRogakeSandharbhameinSaidhantikaevamPrayogikaAdhyayana, Department of Basic Principles, IPGT&RA,Jamnagar
1.Upadhyay Vashudev J (2001) : Medo-Dhatvagni ka SthaulyaRogakeSandharbhameinSaidhantikaevamPrayogikaAdhyayana, Department of Basic Principles, IPGT&RA,Jamnagar
2.Savjani Rekha T (2001) :A clinical study on the management of Sthaulya by Pancha-Tikta and Lekhana-Basti, Department of Kayachikitsa, IPGT &RA, Jamnagar
2.Savjani Rekha T (2001) :A clinical study on the management of Sthaulya by Pancha-Tikta and Lekhana-Basti, Department of Kayachikitsa, IPGT &RA, Jamnagar
3.BuchakeAnand(2002) :An assessment of the activities of RookshaGunaw.s.r. to Sthaulya, Department of Dravyaguna, IPGT &RA, Jamnagar
3.BuchakeAnand(2002) :An assessment of the activities of RookshaGunaw.s.r. to Sthaulya, Department of Dravyaguna, IPGT &RA, Jamnagar
4. Parmar Sheetal (2002): The role of Virechana and Triphaladi Ghana-Vati in the management of Madhumeha (Diabetes mellitus), Department of Kayachikitsa, IPGT &RA, Jamnagar
4. Parmar Sheetal (2002): The role of Virechana and Triphaladi Ghana-Vati in the management of Madhumeha (Diabetes mellitus), Department of Kayachikitsa, IPGT &RA, Jamnagar
5. GujarathiRitesh A ( 2004) : Conceptual and applied aspects of HrasaHetur-Visheshascha in the context of Sthaulya, Department of Basic Principles, IPGT&RA,Jamnagar.
5. GujarathiRitesh A ( 2004) : Conceptual and applied aspects of HrasaHetur-Visheshascha in the context of Sthaulya, Department of Basic Principles, IPGT&RA,Jamnagar.
6. Talathi Sameer (2005) : A study of Saptaparna (Alstoniascholaris) w.s.r. to Sthaulyahara Karma, Department of Dravyaguna, IPGT &RA, Jamnagar
7.Dyuti Dave (2006) : Further Clinical Studies In The Management Of Madhumeha With MedoghnaRasayanaVati, Department of Kayachikitsa, IPGT &RA, Jamnagar
6. Talathi Sameer (2005) : A study of Saptaparna (Alstoniascholaris) w.s.r. to Sthaulyahara Karma, Department of Dravyaguna, IPGT &RA, Jamnagar.
8.Umesh Kumar Sapra (2007) : A Clinical Study Of Hyperlipidaemia And The Effct Of Panchatikta Ghana In Its Management-A Double Blind Study, Department of Kayachikitsa, IPGT &RA, Jamnagar
9.Jyoti Kumari (2007) :A Comparative Clinical Study Of NyagrodhadiGhanavati And Virechana Karma In The Management Of Madhumeha (Diabetes mellitus), Department of Kayachikitsa, IPGT &RA, Jamnagar
7.Dyuti Dave (2006) : Further Clinical Studies In The Management Of Madhumeha With MedoghnaRasayanaVati, Department of Kayachikitsa, IPGT &RA, Jamnagar.
10.Amit Kumar Singh (2007): A comparative study of Vidangadichurna and some indigenous drug in the management of sthaulya (obesity), Department of Kayachikitsa, IPGT &RA, Jamnagar
11. Shweta M Khanapurkar (2008) :Comparative Study of the Efficacy of TriphaladiVati and ShilajitwadiVati in the Management of Prameha (DM), Department of Kayachikitsa, Akhandanand Ayurveda College, Ahmedabad
8.Umesh Kumar Sapra (2007) : A Clinical Study Of Hyperlipidaemia And The Effct Of Panchatikta Ghana In Its Management-A Double Blind Study, Department of Kayachikitsa, IPGT &RA, Jamnagar.
12.Anoop K (2010) :Pharmaco-Therapeutical Evaluation of Anti-Hyperlipidaemic Activity of Vacha (Acorus calamus Linn.) W.S.R. to Sthaulya,Department of Dravyaguna, IPGT &RA, Jamnagar
13. Yogesh K Patil (2010) : A Comparative Study of NyagrodhadiVati and GokshuradiGuggulu in the Management of Madhumeha W.S.R. to Diabetes Mellitus, Department of Kayachikitsa, IPGT &RA, Jamnagar
9.Jyoti Kumari (2007) :A Comparative Clinical Study Of NyagrodhadiGhanavati And Virechana Karma In The Management Of Madhumeha (Diabetes mellitus), Department of Kayachikitsa, IPGT &RA, Jamnagar.
14Falguni S Patel (2010) :A Clinical Study of TryushnadhyaLauhaVati in the Management of Sthaulyaw.s.r. to Obesity, Department of Kayachikitsa, IPGT &RA, Jamnagar
15.Manjiri S Ghorpade (2011) : A Comparative Study of Vatsakadi Ghana Vati and Mamajjaka Ghana Vati in the management of Madhumehaw.s.r. to Diabetes Mellitus, Department of Kayachikitsa, IPGT &RA, Jamnagar
10.Amit Kumar Singh (2007): A comparative study of Vidangadichurna and some indigenous drug in the management of sthaulya (obesity), Department of Kayachikitsa, IPGT &RA, Jamnagar.
16.Kanwar S Singh(2011) : Study on ApathyanimittajaPrameha (Type 2 Diabetes) and its Management with SaptarangyadiGhanvati (A Clinico-Experimental study), Department of Kayachikitsa, IPGT &RA, Jamnagar
17.Shivam Joshi (2013) :A Comparative clinical study of AsanadiGhanavati and GomutraHaritakiVati in KaphaMedoMargavaranaw.s.r. to Dyslipidemia, Department of Kayachikitsa, IPGT &RA, Jamnagar
11. Shweta M Khanapurkar (2008) :Comparative Study of the Efficacy of TriphaladiVati and ShilajitwadiVati in the Management of Prameha (DM), Department of Kayachikitsa, Akhandanand Ayurveda College, Ahmedabad.
18.Ankush Gunjal (2013) : A Clinico-experimental Study on Triphaladi Granules in ApathyaNimittajaPrameha (Type 2 Diabetes mellitus), Department of Kayachikitsa, IPGT &RA, Jamnagar
19.Chitra Devi Sharma (2013) : Comparative Study of AsanadiyogaVati and ShilajitwadiVati in the management of Madhumehaw.s.r. to Diabetes mellitus, Department of Kayachikitsa, IPGT &RA, Jamnagar
12.Anoop K (2010) :Pharmaco-Therapeutical Evaluation of Anti-Hyperlipidaemic Activity of Vacha (Acorus calamus Linn.) W.S.R. to Sthaulya,Department of Dravyaguna, IPGT &RA, Jamnagar.
20.MalivadShila (2014) : A Comparative Study of VidangadiLauh and TriphaladiVati in the Management of Madhumeha with special reference to Diabetes Mellitus (Type II), Department of Kayachikitsa, IPGT &RA, Jamnagar
21.Jatin M Vyas (2014) : A Comparative Study of BilvadiPanchmoolGhanvati and NavakGuggulu in the Management of Sthaulya with special reference to Obesity, Department of Kayachikitsa ,IPGT &RA, Jamnagar
13. Yogesh K Patil (2010) : A Comparative Study of NyagrodhadiVati and GokshuradiGuggulu in the Management of Madhumeha W.S.R. to Diabetes Mellitus, Department of Kayachikitsa, IPGT &RA, Jamnagar.
22. PadharBharatkumarChhaganbhai(2014) :A Comparative Clinical Study of Tryoshnadiguggulu and Lasuna in Management of Dyslipidemia, Department of Kayachikitsa, IPGT &RA, Jamnagar
14Falguni S Patel (2010) :A Clinical Study of TryushnadhyaLauhaVati in the Management of Sthaulyaw.s.r. to Obesity, Department of Kayachikitsa, IPGT &RA, Jamnagar.
15.Manjiri S Ghorpade (2011) : A Comparative Study of Vatsakadi Ghana Vati and Mamajjaka Ghana Vati in the management of Madhumehaw.s.r. to Diabetes Mellitus, Department of Kayachikitsa, IPGT &RA, Jamnagar.
16.Kanwar S Singh(2011) : Study on ApathyanimittajaPrameha (Type 2 Diabetes) and its Management with SaptarangyadiGhanvati (A Clinico-Experimental study), Department of Kayachikitsa, IPGT &RA, Jamnagar.
17.Shivam Joshi (2013) :A Comparative clinical study of AsanadiGhanavati and GomutraHaritakiVati in KaphaMedoMargavaranaw.s.r. to Dyslipidemia, Department of Kayachikitsa, IPGT &RA, Jamnagar.
18.Ankush Gunjal (2013) : A Clinico-experimental Study on Triphaladi Granules in ApathyaNimittajaPrameha (Type 2 Diabetes mellitus), Department of Kayachikitsa, IPGT &RA, Jamnagar.
19.Chitra Devi Sharma (2013) : Comparative Study of AsanadiyogaVati and ShilajitwadiVati in the management of Madhumehaw.s.r. to Diabetes mellitus, Department of Kayachikitsa, IPGT &RA, Jamnagar.
20.MalivadShila (2014) : A Comparative Study of VidangadiLauh and TriphaladiVati in the Management of Madhumeha with special reference to Diabetes Mellitus (Type II), Department of Kayachikitsa, IPGT &RA, Jamnagar.
21.Jatin M Vyas (2014) : A Comparative Study of BilvadiPanchmoolGhanvati and NavakGuggulu in the Management of Sthaulya with special reference to Obesity, Department of Kayachikitsa ,IPGT &RA, Jamnagar.
22. PadharBharatkumarChhaganbhai(2014) :A Comparative Clinical Study of Tryoshnadiguggulu and Lasuna in Management of Dyslipidemia, Department of Kayachikitsa, IPGT &RA, Jamnagar.
23. Bhushan Bhav Ram Prakash Niranjan(2014) : Management of ApathyanimittajaPrameha (Type 2 Diabetes mellitus) with Mayaphala (Quercus infectoria Olivier) A Clinio-experimental Study, Department of Kayachikitsa, IPGT &RA, Jamnagar
23. Bhushan Bhav Ram Prakash Niranjan(2014) : Management of ApathyanimittajaPrameha (Type 2 Diabetes mellitus) with Mayaphala (Quercus infectoria Olivier) A Clinio-experimental Study, Department of Kayachikitsa, IPGT &RA, Jamnagar
==Related Chapters ==
==More information ==
[[ VividhashitapitiyaAdhyaya]] [[Snehadhyaya]] [[LanghanabrimhaniyaAdhyaya]] [[AshtauninditiyaAdhyaya]] [[SantarpaniyaAdhyaya]]
===Related Chapters-===
[[ GrahaniChikitsa]]
[[ Vividhashitapitiya Adhyaya]], [[Snehadhyaya]], [[Langhanabrimhaniya Adhyaya]], [[Ashtauninditiya Adhyaya]], [[Santarpaniya Adhyaya]]
[[ AshtauninditiyaAdhyaya]]
[[ Grahani Chikitsa]] ,[[Prameha Nidana]] ,[[ Prameha Chikitsa]]
[[PramehaNidana]]
==External links ==
== More information ==
[[Adipocyte]] [[fat cells]]
[[Adipocyte]] [[fat cells]]
=== Abbreviations ===
*SAT = Standard Ayurveda Terminology
*Cha. = Charak
*Su. = Sushruta
*Ka. = Kashyapa
*Sha. =Sharangadhara
*Sa. = Samhita
References:
References: