Changes

Dhatu have their respective [[srotas]] (systems). These [[srotas]] get affected due to vitiation of [[dosha]] and lead to diseases. Thus, dhatu are the site of lesion in view of diagnosis and target receptors in view of treatment.  

Dhatu have their respective [[srotas]] (systems). These [[srotas]] get affected due to vitiation of [[dosha]] and lead to diseases. Thus, dhatu are the site of lesion in view of diagnosis and target receptors in view of treatment.  

The increase or decrease of dhatu is also assessed for diagnosis of specific disease. The vitiated dosha reside in dhatu and produce specific clinical features as observed in conditions of jwara and kushtha.  

The increase or decrease of dhatu is also assessed for diagnosis of specific disease. The vitiated [[dosha]] reside in dhatu and produce specific clinical features as observed in conditions of jwara and kushtha.  

In view of prognosis, involvement of a particular dhatu has importance in prognosis also.

In view of prognosis, involvement of a particular dhatu has importance in prognosis also.

In jwara, if doshas are located in [[rasa]], [[rakta]],[[ mamsa]] and [[medas]] dhatu, the conditionsare curable; while if those are located in the [[asthi]] and [[majja]] dhatu, then conditions are difficult to treat. If vitiated dosha are located in [[shukra]] dhatu, the condition is incurable. [Cha.Sa. Chikitsasthana 3/75-83]

In jwara, if doshas are located in [[rasa]], [[rakta]],[[ mamsa]] and [[medas]] dhatu, the conditionsare curable; while if those are located in the [[asthi]] and [[majja]] dhatu, then conditions are difficult to treat. If vitiated dosha are located in [[shukra]] dhatu, the condition is incurable. [Cha.Sa. [[Chikitsa Sthana]] 3/75-83]

In the pathogenesis of prameha(obstinate urinary disorders) [[dosha]] ( [[kapha]], [[pitta]] and [[vata]]) along with  the ten factors called dushya i.e, [[medas]], [[rakta]], [[shukra]], ambu (body fluid), vasa (muscle fat), lasika (lymph),[[ majja]], [[rasa]], [[ojas]]  and [[mamsa]]  play the role.[Cha.Sa. Chikitsasthana 6/8].While considering the prognosis, “Tulyadushyata” (similarity between the characteristics of [[dosha]] and dushya) is a good sign of prognosis[Ashtanga Sangraha Sutra Sthana7/218]

In the pathogenesis of prameha(obstinate urinary disorders) [[dosha]] ( [[kapha]], [[pitta]] and [[vata]]) along with  the ten factors called dushya i.e, [[medas]], [[rakta]], [[shukra]], ambu (body fluid), vasa (muscle fat), lasika (lymph),[[ majja]], [[rasa]], [[ojas]]  and [[mamsa]]  play the role.[Cha.Sa. [[Chikitsa Sthana]] 6/8].While considering the prognosis, “Tulyadushyata” (similarity between the characteristics of [[dosha]] and dushya) is a good sign of prognosis[Ashtanga Sangraha Sutra Sthana7/218]

Pathology of kushtha(skin diseases) is related to deranged physiology of seven factors. They are [[vata]], [[pitta]] and [[kapha]] doshas in aggravated state and dhatus, namely, tvak (since the skin is the organ in which rasa dhatu is present, tvak word is used instead of [[rasa dhatu]]),[[ mamsa]], [[shonita]] and lasika that get deranged due to aggravated [[dosha]]. Involvement of higher dhatu makes the disease more complicated. [Cha.Sa. Chikitsasthana 7/9-10]

Pathology of kushtha(skin diseases) is related to deranged physiology of seven factors. They are [[vata]], [[pitta]] and [[kapha]] doshas in aggravated state and dhatus, namely, tvak (since the skin is the organ in which rasa dhatu is present, tvak word is used instead of [[rasa dhatu]]),[[ mamsa]], [[shonita]] and lasika that get deranged due to aggravated [[dosha]]. Involvement of higher dhatu makes the disease more complicated. [Cha.Sa. [[Chikitsa Sthana]] 7/9-10]

Visarpa (acute spreading erysepelas)also has involvement of seven dhatu which determine the prognosis of the condition. [Cha.Sa. Chikitsasthana 21/12]

Visarpa (acute spreading erysepelas)also has involvement of seven dhatu which determine the prognosis of the condition. [Cha.Sa. [[Chikitsa Sthana]] 21/12]

According to Acharya Sushruta, visha(poison) situated in a particular dhatu produces the dhatupradoshajavikara of that particular dhatu.[Su.sa. Kalpasthana 2/30]

According to Acharya Sushruta, visha(poison) situated in a particular dhatu produces the dhatupradoshajavikara of that particular dhatu.[Su.sa. Kalpa Sthana 2/30]

'''Dhatukshaya (degeneration of tissues)''':  

'''Dhatukshaya (degeneration of tissues)''':  

Dhatukshaya means degeneration or decrement of quality and/or quality of body tissues. It is considered an important event in many disease pathologies.  

Dhatukshaya means degeneration or decrement of quality and/or quality of body tissues. It is considered an important event in many disease pathologies.  

In Rajayakshma (wasting diseases) there is direct relationship to the defect in nourishment of body tissues. The diagnosis and treatment depend upon qualitative and quantitative assessment of dhatu. [Cha.Sa. Nidanasthana 6/ 8-9]

In Rajayakshma (wasting diseases) there is direct relationship to the defect in nourishment of body tissues. The diagnosis and treatment depend upon qualitative and quantitative assessment of dhatu. [Cha.Sa. [[Nidana Sthana]] 6/ 8-9]

Moreover, dhatukshaya is mentioned as the etiology or consequence of different diseases like

Moreover, dhatukshaya is mentioned as the etiology or consequence of different diseases like

• Unmada[Cha.Sa. Chikitsa sthana 9/9]

• Unmada[Cha.Sa. [[Chikitsa Sthana]] 9/9]

• Udara[Cha.Sa. Chikitsa sthana 13/194]

• Udara[Cha.Sa. [[Chikitsa Sthana]] 13/194]

• Pandu [Cha.Sa. Chikitsa sthana 16/5]

• Pandu [Cha.Sa. [[Chikitsa Sthana]] 16/5]

• Hikka, Shwasa[Cha.Sa. Chikitsa sthana 17/82]

• Hikka, Shwasa[Cha.Sa. [[Chikitsa Sthana]] 17/82]

• Kasa[Cha.Sa. Chikitsa sthana 18/153]

• Kasa[Cha.Sa. [[Chikitsa Sthana]] 18/153]

• Chhardi[Cha.Sa. Chikitsa sthana 20/46]

• Chhardi[Cha.Sa. [[Chikitsa Sthana]] 20/46]

• Trushna[Cha.Sa. Chikitsa sthana 22/5]

• Trushna[Cha.Sa. [[Chikitsa Sthana]] 22/5]

• Vatavyadhi [Cha.Sa. Chikitsa sthana 28/59]

• Vatavyadhi [Cha.Sa. [[Chikitsa Sthana]] 28/59]

• Klaibya [Cha.Sa. Chikitsa sthana 30/180]

• Klaibya [Cha.Sa. [[Chikitsa Sthana]] 30/180]

• Marmabhighata- in Kalantarapranahara and VaikalyakaraMarma[Su.Sa. Sharira sthana 6/37-38]

• Marmabhighata- in Kalantarapranahara and Vaikalyakara Marma[Su.Sa. Sharira sthana 6/37-38]

==Importance in preservation of health and prevention: ==

==Importance in preservation of health and prevention: ==