Changes

'''Flowering & Fruiting''':  September - December   

'''Flowering & Fruiting''':  September - December   

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The recipe with ''Jimutaka'' as nasal drops in the management of ''Kamala'' is very popular and has scientific validation. Its Emetic activity has also been revalidated. Being ''tiskanavamaka'' it can be used in ''Nanatmaja Kapha Vikara''. Though it sometimes may create hematemesis.

The recipe with ''Jimutaka'' as nasal drops in the management of ''Kamala'' is very popular and has scientific validation. Its Emetic activity has also been revalidated. Being ''tiskanavamaka'' it can be used in ''Nanatmaja Kapha Vikara''. Though it sometimes may create hematemesis.

==== Researches ====

=== Researches ===

1) Aqueous extract of fruits significantly lowered the serum bilirubin level in chlorpromazine – induced jaundice in rats.[12]  

#Aqueous extract of fruits significantly lowered the serum bilirubin level in chlorpromazine – induced jaundice in rats[12]  

2) The alcoholic and thr ether extracts of the plant showed definite protection against CCl4- induced liver injury in rats[13] .

#The alcoholic and thr ether extracts of the plant showed definite protection against CCl4- induced liver injury in rats[13] .

3) 50% ethanolic extract of whole plant (except roots) showed hypoglycaemic action in rats. The LD50 of the extract in mice was found to be 261 mg/kg i.p.[14] (Aswal et al., 1984).

#50% ethanolic extract of whole plant (except roots) showed hypoglycaemic action in rats. The LD50 of the extract in mice was found to be 261 mg/kg i.p[14] (Aswal et al., 1984).

4) Methanolic extract of Luffa echinata exerts its antiproliferative effects by inducing apoptotic cell death, and causing G2/S arrest in HT-29 cells and it promotes ROS generation[15].  

#Methanolic extract of Luffa echinata exerts its antiproliferative effects by inducing apoptotic cell death, and causing G2/S arrest in HT-29 cells and it promotes ROS generation[15].  

5) In a study on the therapeutic effect of Luffa echinata fruits in 6 patients of viral hepatitis the result reveals that a single administration of drops squeezed from water soaked dry fruits into the nostrils led to a reduction in bilirubin and SGPT levels significantly within 3 to 7 days and this response was accompanied by a substantial relief in clinical symptoms especially anorexia and malaise.The nasal secretions contained total bilirubin ranging from 1.62 to 5.5mg per cent, the levels not being higher than the serum levels. The observations thus could justify the simple explanation of the relief of jaundice by enhanced nasal excretion of bilirubin. The possibility of the absorption of the active principle of the plant through the nasal mucosa and then action on the liver has been proposed.[16]

#In a study on the therapeutic effect of Luffa echinata fruits in 6 patients of viral hepatitis the result reveals that a single administration of drops squeezed from water soaked dry fruits into the nostrils led to a reduction in bilirubin and SGPT levels significantly within 3 to 7 days and this response was accompanied by a substantial relief in clinical symptoms especially anorexia and malaise.The nasal secretions contained total bilirubin ranging from 1.62 to 5.5mg per cent, the levels not being higher than the serum levels. The observations thus could justify the simple explanation of the relief of jaundice by enhanced nasal excretion of bilirubin. The possibility of the absorption of the active principle of the plant through the nasal mucosa and then action on the liver has been proposed.[16]

 

#Pharmacological activity

Pharmacological activity profile:

*Anti-arthritic activity [17]

Anti-arthritic activity [17]

*Hepatoprotective activity[18]

Hepatoprotective activity[18]

*Anti-cancer activity [19]

Anti-cancer activity [19]

Thirst area: Thyroid disorders became common especially in female. Thyroid disorders especially hypothyroidism should be treated by given Vamana by ''Jimutaka''. It can be used as emetic  in de-addiction due to alcohol withdrawl syndrome due to its hepato protective activity.

'''Thrust area:''' Thyroid disorders became common especially in female. Thyroid disorders especially hypothyroidism should be treated by given Vamana by ''Jimutaka''. It can be used as emetic  in de-addiction due to alcohol withdrawal syndrome due to its hepato protective activity.

=== Reference ===

=== Reference ===