Changes

The crux of prevention of diseases is maintaining a balance of [[dosha]] from time of conception. If the [[dosha]] are in equilibrium within the body of an individual, the person does not suffer from diseases. The imbalance including predominance of a single [[dosha]] in [[prakriti]] makes him/her susceptible to diseases. The balance of [[dosha]] can be maintained through habitual intake of diet of all rasas and following those regimens with opposite properties of dominant [[dosha]] in [[prakriti]]. Therefore, to know the predominant [[dosha]] in one’s constitution is very important for prescribing suitable diet and lifestyle regimen in prevention and management of diseases. The suitable dietary regimen for each [[dosha]] [[prakriti]] is described in detail in the eighth chapter of [[Vimana Sthana]].  

The crux of prevention of diseases is maintaining a balance of [[dosha]] from time of conception. If the [[dosha]] are in equilibrium within the body of an individual, the person does not suffer from diseases. The imbalance including predominance of a single [[dosha]] in [[prakriti]] makes him/her susceptible to diseases. The balance of [[dosha]] can be maintained through habitual intake of diet of all rasas and following those regimens with opposite properties of dominant [[dosha]] in [[prakriti]]. Therefore, to know the predominant [[dosha]] in one’s constitution is very important for prescribing suitable diet and lifestyle regimen in prevention and management of diseases. The suitable dietary regimen for each [[dosha]] [[prakriti]] is described in detail in the eighth chapter of [[Vimana Sthana]].  

====Phenotypic co-relation of [[prakriti]]====

====Phenotypic co-relation of [[prakriti]]====

Every individual is different from another and hence should be considered as a separate entity.<ref> Valiathan, M. S., The Legacy of Caraka, Orient Longman, Chennai, 2003.</ref>  The three broad classes of ‘prakriti’  are based on certain physical, physiological and psychological characters.<ref> Swoboda, R. E., Prakruti: Ayurvedic Con- stitution, Motilal Banarasidas Publishers, Varanasi, 1996.</ref> The scientists suggest phenotypic classification of India’s traditional medicine has a genetic basis; and its Prakriti-based practice in vogue for many centuries resonates with personalized medicine. <ref name="Govindraj P Genome"> Govindaraj P, Nizamuddin S, Sharath A, et al. Genome-wide analysis correlates Ayurveda Prakriti. Nat Publ Gr.:1-12. doi:10.1038/srep15786</ref>. Thus [[prakriti]] concept is independent of racial, ethnic or geographical considerations and may provide appropriate means of classifying phenotypes to be considered collectively for genotyping.  In a study, the researchers postulated that human phenome based on prakriti, namely [[kapha]], [[pitta]] and [[vata]] have genetic connotation that could help classifying human population based on broad phenotype clusters. Accordingly HLA DR alleles among various [[prakriti]] classes and demonstrated significant associations were analysed. <ref>Patwardhan, B., Joshi, K. and Chopra, A., J. Altern. Complement. Med., 2005, 11, 349– 353. </ref>  The concept of constitutional uniqueness of human individuals and personalized prescription of diet and drugs is special feature of [[Ayurveda]]. This has similarities with the pharmacogenomics and customized medicine.<ref>Patwardhan, B., Indian Drugs, 2000, 37, 213–227.</ref>   

Every individual is different from another and hence should be considered as a separate entity.<ref> Valiathan, M. S., The Legacy of Caraka, Orient Longman, Chennai, 2003.</ref>  The three broad classes of ‘prakriti’  are based on certain physical, physiological and psychological characters.<ref> Swoboda, R. E., Prakruti: Ayurvedic Con- stitution, Motilal Banarasidas Publishers, Varanasi, 1996.</ref> The scientists suggest phenotypic classification of India’s traditional medicine has a genetic basis; and its Prakriti-based practice in vogue for many centuries resonates with personalized medicine. <ref name= "Govindraj P Genome"> Govindaraj P, Nizamuddin S, Sharath A, et al. Genome-wide analysis correlates Ayurveda Prakriti. Nat Publ Gr.:1-12. doi:10.1038/srep15786</ref>. Thus [[prakriti]] concept is independent of racial, ethnic or geographical considerations and may provide appropriate means of classifying phenotypes to be considered collectively for genotyping.  In a study, the researchers postulated that human phenome based on prakriti, namely [[kapha]], [[pitta]] and [[vata]] have genetic connotation that could help classifying human population based on broad phenotype clusters. Accordingly HLA DR alleles among various [[prakriti]] classes and demonstrated significant associations were analysed. <ref>Patwardhan, B., Joshi, K. and Chopra, A., J. Altern. Complement. Med., 2005, 11, 349– 353. </ref>  The concept of constitutional uniqueness of human individuals and personalized prescription of diet and drugs is special feature of [[Ayurveda]]. This has similarities with the pharmacogenomics and customized medicine.<ref>Patwardhan, B., Indian Drugs, 2000, 37, 213–227.</ref>   

In a study on  genome-wide SNP (single nucleotide polymorphism) analysis of 262 well-classified male individuals (after screening 3416 subjects) belonging to three Prakriti ([[Vata]], [[Pitta]], [[Kapha]]), it is observed that PGM1 correlates with phenotype of Pitta as described in the ancient text of Charaka Samhita.<ref> name="Govindraj P Genome"<ref/>

In a study on  genome-wide SNP (single nucleotide polymorphism) analysis of 262 well-classified male individuals (after screening 3416 subjects) belonging to three Prakriti ([[Vata]], [[Pitta]], [[Kapha]]), it is observed that PGM1 correlates with phenotype of Pitta as described in the ancient text of Charaka Samhita.<ref name= "Govindraj P Genome" />

=== Signs of derangement of internal metabolism and excretion ===

=== Signs of derangement of internal metabolism and excretion ===