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→Chart 3: Diagrammatic representation of importance of Agni2
==== Chart 2: Factors involved in ''Agni'' process ====
==== Chart 2: Factors involved in ''Agni'' process ====
==== Chart 3: Diagrammatic representation of importance of Agni2 ====
==== Chart 3: Diagrammatic representation of importance of ''Agni'' ====
Determination of psychosomatic constitution as well as disease susceptibility of an individual in population through genetic trait is known as prakriti. Prakriti is a broad term encompasses all the three genotype, phenotype as well as endophenotype. The concept of prakriti in Ayurveda is related to the bio-characteristic of an individual in healthy state and its vulnerability for particular diseases. According to Ayurveda, prakriti of an individual once determined at the time of fertilization remains unchanged throughout life though it is well influenced by environment. Role of environment in determination of prakriti during prenatal period is as important as postnatal period. Reviewing the human embryology, it can be postulated that the three primitive germinal layers namely ectoderm, mesoderm and endoderm can be correlated with vatika, paittika and kaphaja trait. According to Ayurveda at the time of fertilization the doshika prakriti is determined by the doshika predominance of shukra (sperm) and shonita (ovum) that represent the fastidious genetic alignment of chromosomes in sperm and ovum and decide the genetic trait of zygote. Robust research is being conducted to study the link between prakriti and genes.[ link https://www.researchgate.net/profile/Mitali_Mukerji2/publication/51647769_Ayurgenomics_A_New_Way_of_Threading_Molecular_Variability_for_Stratified_Medicine/links/00b7d5179290650224000000.pdf?origin=publication_detail]
Determination of psychosomatic constitution as well as disease susceptibility of an individual in population through genetic trait is known as ''prakriti''. ''Prakriti'' is a broad term encompasses all the three genotype, phenotype as well as endophenotype. The concept of prakriti in[https://en.wikipedia.org/wiki/Ayurveda Ayurveda] is related to the bio-characteristic of an individual in healthy state and its vulnerability for particular diseases. According to [https://en.wikipedia.org/wiki/Ayurveda Ayurveda], ''prakriti'' of an individual once determined at the time of fertilization remains unchanged throughout life though it is well influenced by environment. Role of environment in determination of ''prakriti'' during prenatal period is as important as postnatal period. Reviewing the human embryology, it can be postulated that the three primitive germinal layers namely ectoderm, mesoderm and endoderm can be correlated with ''vatika, paittika'' and ''kaphaja'' trait. According to [https://en.wikipedia.org/wiki/Ayurveda Ayurveda] at the time of fertilization the ''doshika prakriti'' is determined by the ''doshika'' predominance of ''shukra'' (sperm) and ''shonita'' (ovum) that represent the fastidious genetic alignment of chromosomes in sperm and ovum and decide the genetic trait of zygote. Robust research is being conducted to study the link between ''prakriti'' and genes.
In Nidana sthana 4 (prameha nidana), Acharya says that the development of disease is multifactorial and it depends upon both the virulence of pathogens (nidana) as well as host response (dushya). Response of the host can be quantified by using prakriti as a parameter. [13]
In [[Nidana Sthana]] Chapter 4 ([[Prameha Nidana]]), Acharya says that the development of disease is multifactorial and it depends upon both the virulence of pathogens (''nidana'') as well as host response (''dushya''). Response of the host can be quantified by using ''prakriti'' as a parameter. [13]
=== Applied aspect for future research ===
1. Scientific validation of term prakriti and standardization of doshika and manasa prakriti.
1. Scientific validation of term prakriti and standardization of doshika and manasa prakriti.
2. Preparation of protocol for the classification of diseases on the basis of vata, pitta and kapha.
2. Preparation of protocol for the classification of diseases on the basis of vata, pitta and kapha.
1. Searching genetic trait for different prakriti and disease susceptibility accordingly.
1. Searching genetic trait for different prakriti and disease susceptibility accordingly.
2. Standardization of Jathragni, Bhutagni and Dhatvagni.
2. Standardization of Jathragni, Bhutagni and Dhatvagni.
Further reading:
=== Further reading ===
1. Kajaria Divya, Tripathi J.S, Tiwari S.K. Clinical Application of Concept of Agni. Asian Journal of Pharmaceutical Research. 2014; 4(1):1-5.
1. Kajaria Divya, Tripathi J.S, Tiwari S.K. Clinical Application of Concept of Agni. Asian Journal of Pharmaceutical Research. 2014; 4(1):1-5.