Difference between revisions of "Dhatu"

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|title=Dhatu
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|keywords=Dhatu, Rasa dhatu, Rakta dhatu, Mamsa dhatu, Meda dhatu, Asthi dhatu, Majja dhatu, Shukra dhatu, Vata, Pitta, Kapha, Dhatu and body tissues, Dhatvagni and tissue metabolism, Stem cells and poshaka dhatu, ayurveda, Indian system of medicine, alternative medicine, body physiology
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|description=Dhatus are body constituents which build the basic structure and carry various physiological functions. They work as body tissues, stabilize and sustain body.
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|image=http://www.carakasamhitaonline.com/resources/assets/ogimgs.jpg
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<p style="text-align:justify;">Dhatu means body constituents which build the basic structure and carry various physiological functions. They work as body tissues, stabilize and sustain body. (Code:SAT-B.425)<ref>National AYUSH Morbidity and Standardized Terminologies Electronic Portal by Ministry of AYUSH Available on http://namstp.ayush.gov.in/#/sat</ref> 
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The structural and functional integrity of body depends upon dhatu. Therefore, it is important to understand the concept of dhatu.
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<br/>
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In physics and chemistry, the term dhatu is applied to denote metals like iron, copper etc. In Sanskrit grammar, the term is applied to denote root verb and derivation. </p>
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{{Infobox
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|title =  Contributors
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|label1 = Section/Chapter/topic
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|data1 = [[Sharira]] / [[Dhatu]]
  
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|label2 = Authors
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|data2 = Anagha S., [[Yogesh Deole|Deole Y.S.]]
  
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Dhatus are body constituents which build the basic structure and carry various physiological functions. They work as body tissues, stabilize and sustain body. (Code:SAT-B.425)<ref>National AYUSH Morbidity and Standardized Terminologies Electronic Portal by Ministry of AYUSH Available on http://namstp.ayush.gov.in/#/sat</ref> 
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|label3 = Reviewer and Editor
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The structural and functional integrity of body depends upon dhatu. Therefore, it is important to understand the concept of dhatu.
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|data3 = [[Gopal Basisht|Basisht G.]]
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|label4 = Affiliations
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|data4 = [[Charak Samhita Research, Training and Development Centre]], I.P.G.T.& R.A., Jamnagar
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|label5 = Correspondence email
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|data5 = carakasamhita@gmail.com
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|label6 = Publisher
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|data6 = [[Charak Samhita Research, Training and Development Centre]], I.T.R.A., Jamnagar, India
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|label7 = Date of first publication:
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|data7 = April 16, 2020
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|label8 = DOI
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|data8 = [https://doi.org/10.47468/CSNE.2020.e01.s09.012 10.47468/CSNE.2020.e01.s09.012]
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}}
  
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In physics and chemistry, the term dhatu is applied to denote metals like iron, copper etc. 
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==Etymology and derivation==
  
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In Sanskrit grammar, the term is applied to denote root verb and derivation.
 
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==Etymology and derivation:==
 
 
The word ‘dhatu’ is derived from the word root “Dha” by adding suffix “Tun”.
 
The word ‘dhatu’ is derived from the word root “Dha” by adding suffix “Tun”.
 
The derivation of the word is as follows-
 
The derivation of the word is as follows-
  
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“डुधाञधारणपोषणयोः”- meaning that which sustains and nourishes.
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“डु धाञ धारणपोषणयोः”- meaning that which sustains and nourishes.
  
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In general, the Sanskrit word convey the meaning of a component, constituent, elementary substance, verbal, grammatical root or a metal.<ref>https://www.sanskrit-lexicon.uni-koeln.de/scans/MWScan/2014/web/webtc/indexcaller.php</ref>
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In general, the Sanskrit word conveys the meaning of a component, constituent, elementary substance, verbal, grammatical root or a metal.<ref>https://www.sanskrit-lexicon.uni-koeln.de/scans/MWScan/2014/web/webtc/indexcaller.php</ref>
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==Synonyms ==
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When these physiological constituents are affected by dosha and lead to abnormalities, they are termed as dushya. [A.Hr. Sutra Sthana 1/13]
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==Meanings in different contexts ==
  
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==Synonyms: ==
 
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When these physiological constituents are affected by dosha and lead to abnormalities, they are termed as dushya. [ Ash.Hru. Sutra Sthana1/13]
 
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==Meanings in different contexts: ==
 
 
In Charak Samhita, the word dhatu is used in different contexts as follows.
 
In Charak Samhita, the word dhatu is used in different contexts as follows.
  
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• Sapta dhatu (Seven structural components)[Table1]
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*Seven structural components(Sapta [[dhatu]])[Table1]
  
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• As a collective term for [[dosha]]-[[dhatu]]-[[mala]][Table1]
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*As a collective term for [[dosha]]-[[dhatu]]-[[mala]][Table1]
  
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• [[Tridosha]]/ a particular [[dosha]]([[vata]],[[pitta]], [[kapha]]) [Cha. Sa. [[Vimana Sthana]] 8/122]
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*[[Tridosha]]/ a particular [[dosha]]([[vata]],[[pitta]], [[kapha]]) [Cha. Sa. [[Vimana Sthana]] 8/122]
  
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• [[Panchamahabhuta]](five elements) [Cha. Sa. [[Sutra Sthana]] 8/122, Cha. Sa. [[Sharira Sthana]] 4/10, Cha. Sa. [[Sharira Sthana]] 8/15]
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*five elements([[Panchamahabhuta]]) [Cha. Sa. [[Sutra Sthana]] 8/122, Cha. Sa. [[Sharira Sthana]] 4/10, Cha. Sa. [[Sharira Sthana]] 8/15]
  
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• Denoting any bodily element/anatomical structure[Cha. Sa. [[Sharira Sthana]] 5/12]
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*Denoting any bodily element/anatomical structure[Cha. Sa. [[Sharira Sthana]] 5/12]
  
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• Denoting the components of garbha(Shad dhatu) [Table1]
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*Denoting the components of garbha(Shad dhatu) [Table1]
  
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• Loha (metals) [Table1]
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*metals(Loha) [Table1]
  
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'''Special Considerations'''-
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=== Special Considerations ===
  
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• Chetana dhatu- denoting [[Atma]](soul) [Cha. Sa. [[Sharira Sthana]] 2/32]
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*Chetana dhatu- denoting soul([[Atma]]) [Cha. Sa. [[Sharira Sthana]] 2/32]
  
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• Beejarupa dhatu- denoting [[shukra]](sperm- containing the essence of all seven dhatu of man) [Cha. Sa. [[Sharira Sthana]] 4/7,10]
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*Beejarupa dhatu- denoting sperm- containing the essence of all seven dhatu of man([[shukra]]) [Cha. Sa. [[Sharira Sthana]] 4/7,10]
  
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• Pradhana dhatu- denoting [[shukra]](semen) [Cha. Sa. [[Chikitsa Sthana]] 30/184]
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*Pradhana dhatu- denoting semen([[shukra]]) [Cha. Sa. [[Chikitsa Sthana]] 30/184]
  
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• Dravarupa dhatu- denoting [[pitta]][Cha. Sa. [[Chikitsa Sthana]] 4/8]
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*Dravarupa dhatu- denoting [[pitta]][Cha. Sa. [[Chikitsa Sthana]] 4/8]
  
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• Apdhatu- denoting watery elements in body [Cha. Sa. [[Chikitsa Sthana]] 22/11,13,21]
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*Apdhatu- denoting watery elements in body [Cha. Sa. [[Chikitsa Sthana]] 22/11,13,21]
  
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• Dhatu term denoting [[vayu]][Cha. Sa.[[ Chikitsa Sthana ]] 3/217]
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*Dhatu term denoting [[vayu]][Cha. Sa.[[ Chikitsa Sthana ]] 3/217]
  
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• Dhatu term denoting [[pitta]] [Cha. Sa. [[Vimana Sthana]] 3/39]
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*Dhatu term denoting [[pitta]] [Cha. Sa. [[Vimana Sthana]] 3/39]
  
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• Dhatu term denoting any karyadravya (a product)[Cha. Sa. [[Sutra Sthana]] 12/8]
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*Dhatu term denoting any product (karyadravya)[Cha. Sa. [[Sutra Sthana]] 12/8]
  
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 '''Seven dhatu'''
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=== Seven dhatu ===
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The term generally refers the seven structural components of body.  
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The term generally refers to the seven structural components of the body.  
  
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They are
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They are as below:
  
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1. [[Rasa]] : plasma and lymph
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#[[Rasa dhatu]]: plasma and lymph
  
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2. [[Rakta]]: blood tissue
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#[[Rakta dhatu]]: blood tissue
  
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3. [[Mamsa]]: muscle tissue
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#[[Mamsa dhatu]]: muscle tissue
  
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4. [[Meda]]: adipose tissue
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#[[Meda dhatu]]: adipose tissue
  
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5. [[Asthi]]: bone tissue
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#[[Asthi dhatu]]: bone tissue
  
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6. [[Majja]]: bone marrow
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#[[Majja dhatu]]: bone marrow
  
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7. [[Shukra]]: reproductive fluids; semen
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#[[Shukra dhatu]]: reproductive fluids; semen
  
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 '''Tridhatu'''[Cha. Sa. [[Chikitsa Sthana]] 3/73]
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=== Three dhatu ===
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Three [[dosha]] are termed as dhatu as they are responsible for maintaining body functions.
  
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1.[[Vata]]
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#[[Vata]]
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#[[Pitta]]
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#[[Kapha]]  [Cha. Sa. [[Chikitsa Sthana]] 3/73]
  
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2.[[Pitta]]
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=== Six dhatu ===
  
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3.[[Kapha]]
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These are the components of embryo(garbha) including [[panchamahabhuta]] and [[atma]]. [Cha. Sa. [[Sharira Sthana]] 1/16]
  
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 '''Shad dhatu'''- the components of garbha(embryo) [Cha. Sa. [[Sharira Sthana]] 1/16]
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It denotes the combination of [[akasha]], [[vayu]], [[Agni]], [[jala]], [[prithvi]](i.e. the five elements) and soul([[atma]]).
  
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It denotes the combination of [[akasha]], [[vayu]], [[Agni]], [[jala]], [[prithvi]](i.e. the five elements) and Atma(soul).
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=== Eight dhatu ===
  
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 '''Ashta dhatu''' –the components of [[prakriti]][Cha. Sa. [[Sharira Sthana]] 1/17]
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These are components of [[prakriti]]. [Cha. Sa. [[Sharira Sthana]] 1/17]
  
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It consists of five mahabhutas (in their subtle form), ahamkara (ego),  
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It consists of five [[mahabhuta]] (in their subtle form), ego (ahamkara), intellect(mahat), and primordial element([[Avyakta|avyakta]]).
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mahat (intellect) and avyakta (primordial element)
 
  
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 '''Chaturvimshati dhatu'''-24 components of [[purusha]][Cha. Sa. [[Sharira Sthana]] 1/17]
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=== Twenty four dhatu ===
  
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[[Purusha]] comprises of twenty four dhatus, i.e. mind, ten indriyas (sensory and motor organs), five objects of sense organs and [[prakriti]] (consisting of eight dhatu).
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These are 24 components of [[purusha]]. [Cha. Sa. [[Sharira Sthana]] 1/17]
  
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'''Nourishment of dhatu''':
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[[Purusha]] comprises of twenty-four dhatu, i.e. mind, ten sensory and motor organs (indriya), five objects of sense organs, and [[prakriti]] (consisting of eight dhatu).
  
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The dhatus are formed from prasada (first transformed food into ahara -rasa (nutrient fluid). This nutrient fluid nourishes body components in sequential pattern. It first nourishes the [[rasa dhatu]], then [[rakta]], then [[mamsa]] etc. The nutrients present in the food nourish respective dhatu qualitatively and quantitatively. [Cha. Sa. [[Sutra Sthana]] 28/4]
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== Formation and nourishment of dhatu ==
 +
 
 +
The dhatu are formed from first transformed food into nutrient fluid called ahara-rasa (prasada). This nutrient fluid nourishes body components in a sequential pattern. It first nourishes the [[rasa dhatu]], then [[rakta]], then [[mamsa]] etc. The nutrients present in the food nourish respective dhatu qualitatively and quantitatively. [Cha. Sa. [[Sutra Sthana]] 28/4]
  
 
Furthermore, during the process of metabolism, dhatus undergo a specific pathway through their own characteristic digestive enzymes termed as ‘dhatvagni.  In this process, each dhatu gets converted into two parts: poshya(which nourishes itself) and poshaka (which nourishes others). The poshya fraction is responsible for dhatu’s own nourishment and functions. The poshaka fraction nourishes further other dhatus.
 
Furthermore, during the process of metabolism, dhatus undergo a specific pathway through their own characteristic digestive enzymes termed as ‘dhatvagni.  In this process, each dhatu gets converted into two parts: poshya(which nourishes itself) and poshaka (which nourishes others). The poshya fraction is responsible for dhatu’s own nourishment and functions. The poshaka fraction nourishes further other dhatus.
  
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Upadhatu (by products) and [[mala]](waste products) are also formed in this dhatu metabolic process.  
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By-products(Upadhatu) and waste products([[mala]]) are also formed in this dhatu metabolic process.  
 
   
 
   
 
Thus, each dhatu nourishes its next sequential dhatu.[Cha. Sa.[[ Chikitsa Sthana ]] 8/39]
 
Thus, each dhatu nourishes its next sequential dhatu.[Cha. Sa.[[ Chikitsa Sthana ]] 8/39]
  
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'''Functions of Dhatu'''
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== Functions of Dhatu ==
  
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The major functions of seven dhatus are listed as preenana(nourishment), jeevana(vitalizing), lepa(covering), snehana(moistening), dharana(supporting),poorana(filling), and garbhoptpadana(reproduction) respectively.[Ashtanga Hrudaya sutra sthana 9/4]
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The major functions of seven dhatus are listed as nourishment(preenana), vitalizing(jeevana), covering(lepa), moistening(snehana), supporting(dharana),filling(poorana), and reproduction(garbhoptpadana) respectively.[A.Hr. sutra sthana 9/4]
  
 
{| class="wikitable"
 
{| class="wikitable"
 
|-
 
|-
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! Sr. No. !!Dhatu  !![[Guna]] (qualities)  !! [[Karma]](functions)  
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! Sr. No. !!Dhatu  !!qualities ([[Guna]])  !! functions([[Karma]])  
 
|-
 
|-
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| 1 || [[Rasa]] || Drava, snigdha, sara, manda || Tushti (satiety), Preenan(nourishment), Raktapushti (nourishing blood)
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| 1 || [[Rasa dhatu]] || Drava, snigdha, sara, manda || satiety (Tushti), nourishment(Preenan), nourishing blood (Raktapushti)
 
|-
 
|-
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| 2 || [[Rakta]] || Drava, sara, visra, laghu || Jeevana (vitality), Varnaprasadana(complexion), Mamsapushti (nourishing muscles)
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| 2 || [[Rakta dhatu]] || Drava, sara, visra, laghu || vitality (Jeevana), complexion(Varnaprasadana), nourishing muscles (Mamsapushti)
 
|-
 
|-
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| 3 || [[Mamsa]] || Sthira, guru, snigdha, pichila || Dehapushti (nourishing body), Lepa (body mass) ,medapushti(nourishing adipose tissue)
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| 3 || [[Mamsa dhatu]] || Sthira, guru, snigdha, pichila || nourishing body (Dehapushti), body mass (Lepa) ,nourishing adipose tissue(medapushti)
 
|-
 
|-
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| 4 || [[Medas]] || Snigdha, guru,shlakshna, mrudu, Sandra ||Snehana (oleation) of eyes and body,drudhatwa(firmness), asthipushti (nourishing bones)
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| 4 || [[Meda dhatu]] || Snigdha, guru,shlakshna, mrudu, Sandra ||oleation (Snehana) of eyes and body,firmness(drudhatwa), nourishing bones (asthipushti)
 
|-
 
|-
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| 5 || [[Asthi]] || Sthira,guru, kathina, khara || Dharana(holding body frame), Majjapushti (nourishing bone marrow)  
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| 5 || [[Asthi dhatu]] || Sthira,guru, kathina, khara || holding body frame(Dharana), nourishing bone marrow (Majjapushti)  
 
|-
 
|-
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| 6 || [[Majja]] || Sandra, drava, snigdha,shlakshna ||Snehana (oleation), Balakara(strength), Asthipoorana(filling up bones), Shukrapushti (nourishing reproductive tissues)
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| 6 || [[Majja dhatu]] || Sandra, drava, snigdha,shlakshna ||oleation (Snehana), strength(Balakara), filling up bones(Asthipoorana), nourishing reproductive tissues (Shukrapushti)
 
|-
 
|-
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|| 7 || [[Shukra]] ||Drava, sheeta, snigdha || Harsha (pleasure), Bala (strength), Garbhotpadana(reproduction)
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|| 7 || [[Shukra dhatu]] ||Drava, sheeta, snigdha ||pleasure (Harsha), strength (Bala), reproduction(Garbhotpadana)
 
|}
 
|}
  
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'''Concept of Upadhatu and Dhatumala:'''
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=== Concept of Upadhatu and Dhatumala ===
  
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Upadhatu and [[mala]] are by-products formed during process of metabolism. The by-products are categorized into these two groups according to their functional importance. Dhatu supports the body and nourishes the subsequent dhatu. However,upa-dhatus do not nourish any further element. They only carry physiological functions and only support body.  
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Upadhatu and [[mala]] are by-products formed during the process of metabolism. The by-products are categorized into these two groups according to their functional importance. Dhatu supports the body and nourishes the subsequent dhatu. However,upadhatus do not nourish any further element. They only carry physiological functions and only support the body.  
  
 
The other by-products are dhatu-mala or excretory products. They can get easily vitiated by pathogenic factors; hence they are termed as [[mala]].  
 
The other by-products are dhatu-mala or excretory products. They can get easily vitiated by pathogenic factors; hence they are termed as [[mala]].  
Line 134: Line 177:
 
{| class="wikitable"
 
{| class="wikitable"
 
|-
 
|-
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! Sr. No. !!Dhatu  !!Upadhatu  !! [[Mala]](functions)
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! Sr. No. !!Dhatu  !!Upadhatu  !! [[Mala]]
 
|-
 
|-
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| 1. || [[Rasa]] || Stanya (breast milk), [[Rakta]](menstrual blood) || [[Kapha]]
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| 1. || [[Rasa]] || breast milk (Stanya), menstrual blood([[Rakta]]) || [[Kapha]]
 
|-
 
|-
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| 2. || [[Rakta]] || Kandara (artery), sira (blood vessels), artava(menstrual blood)* || [[Pitta]]
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| 2. || [[Rakta]] || artery  (Kandara), blood vessels (sira), menstrual blood(artava)* || [[Pitta]]
 
|-
 
|-
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| 3. || [[Mamsa]] || Vasa (muscle fat), six layers of skin || Kha-mala (excreta in ear, nose)  
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| 3. || [[Mamsa]] || muscle fat (Vasa), six layers of skin || excreta in ear, nose etc.(Kha-mala )  
 
|-
 
|-
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| 4. || [[Meda]] || Snayu (tendons) || Sweda (sweat)
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| 4. || [[Meda]] || tendons (Snayu) || sweat (Sweda)
 
|-  
 
|-  
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| 5. || [[Asthi]] || Danta(teeth)*nakha(nails)# || Kesha(scalp hair) and loma(body hair)
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| 5. || [[Asthi]] || teeth(Danta)*nails(nakha)# || scalp hair(Kesha) and body hair(loma)
 
|-
 
|-
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| 6. || [[Majja]] || Kesha(hair)* || Akshi-twacha-vit sneha(oiliness in eyes, skin and stools)  
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| 6. || [[Majja]] || hair(Kesha)* || oiliness in eyes, skin and stools(Akshi-twacha-vit sneha)  
 
|-
 
|-
 
| 7. || [[Shukra]] || [[Ojas]]* || --
 
| 7. || [[Shukra]] || [[Ojas]]* || --
 
|}
 
|}
  
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* *As opined by Sharangadhara[Sharangadhara Sam. Purvakhanda chapter 5] ,  #As opined by Sushruta [Su.Sa. Sutra Sthana 46/529]
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* *As opined by Sharangadhara[Sha.Sa. Purvakhanda chapter 5],  # As opined by Sushruta [Su.Sa. Sutra Sthana 46/529]
  
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==Importance of knowledge of dhatu in clinical diagnosis and treatment==  
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== Importance of knowledge of dhatu in clinical diagnosis and treatment ==  
  
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'''Assessment of sara (excellent quality of dhatu)''':
+
=== Assessment of sara (excellent quality of dhatu) ===
  
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Sara means the excellent quality of dhatu. It is highly related with the health of tissue and endurance to pathogens. The excellent quality depends upon dhatvagni (metabolism). It is one of the assessment parameters to determine strength of an individual in ten-fold examination. The individuals are categorized on the basis of predominance of a particular dhatu as twaksara, raktasara, mamsasara, medosara, asthisara, majjasara and shukrasara. [Cha.Sa. [[Vimana Sthana]] 8/102]
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Sara means the excellent quality of dhatu. It is highly related with the health of tissue and endurance to pathogens. The excellent quality depends upon metabolism(dhatvagni). It is one of the assessment parameters to determine strength of an individual in ten-fold examination. The individuals are categorized on the basis of predominance of a particular dhatu as twaksara, raktasara, mamsasara, medosara, asthisara, majjasara and shukrasara. [Cha.Sa. [[Vimana Sthana]] 8/102]
  
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==Importance of concept in diagnosis:==
+
== Importance in diagnosis ==
−
Dhatu have their respective [[srotas]] (systems). These [[srotas]] get affected due to vitiation of [[dosha]] and lead to diseases. Thus, dhatu are the site of lesion in view of diagnosis and target receptors in view of treatment.
 
  
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The increase or decrease of dhatu is also assessed for diagnosis of specific disease. The vitiated dosha reside in dhatu and produce specific clinical features as observed in conditions of jwara and kushtha.  
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Dhatu have their respective systems([[srotas]]). These [[srotas]] get affected due to the vitiation of [[dosha]] and lead to diseases. Thus, dhatu are the site of lesion in view of diagnosis and target receptors in view of treatment.  
  
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In view of prognosis, involvement of a particular dhatu has importance in prognosis also.
+
The increase or decrease of dhatu is also assessed for diagnosis of specific disease. The vitiated [[dosha]] reside in dhatu and produce specific clinical features as observed in the conditions of jwara and kushtha.  
  
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In jwara, if doshas are located in [[rasa]], [[rakta]],[[ mamsa]] and [[medas]] dhatu, the conditionsare curable; while if those are located in the [[asthi]] and [[majja]] dhatu, then conditions are difficult to treat. If vitiated dosha are located in [[shukra]] dhatu, the condition is incurable. [Cha.Sa. Chikitsasthana 3/75-83]
+
In view of prognosis, the involvement of a particular dhatu has importance in prognosis also.
  
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In the pathogenesis of prameha(obstinate urinary disorders) [[dosha]] ( [[kapha]], [[pitta]] and [[vata]]) along with  the ten factors called dushya i.e, [[medas]], [[rakta]], [[shukra]], ambu (body fluid), vasa (muscle fat), lasika (lymph),[[ majja]], [[rasa]], [[ojas]]  and [[mamsa]]  play the role.[Cha.Sa. Chikitsasthana 6/8].While considering the prognosis, “Tulyadushyata” (similarity between the characteristics of [[dosha]] and dushya) is a good sign of prognosis[Ashtanga Sangraha Sutra Sthana7/218]
+
In jwara, if doshas are located in [[rasa]], [[rakta]],[[ mamsa]] and [[medas]] dhatu, the conditionsare curable; while if those are located in the [[asthi]] and [[majja]] dhatu, then conditions are difficult to treat. If vitiated dosha are located in [[shukra]] dhatu, the condition is incurable. [Cha.Sa. [[Chikitsa Sthana]] 3/75-83]
  
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Pathology of kushtha(skin diseases) is related to deranged physiology of seven factors. They are [[vata]], [[pitta]] and [[kapha]] doshas in aggravated state and dhatus, namely, tvak (since the skin is the organ in which rasa dhatu is present, tvak word is used instead of [[rasa dhatu]]),[[ mamsa]], [[shonita]] and lasika that get deranged due to aggravated [[dosha]]. Involvement of higher dhatu makes the disease more complicated. [Cha.Sa. Chikitsasthana 7/9-10]
+
In the pathogenesis of obstinate urinary disorders(prameha) [[dosha]] ( [[kapha]], [[pitta]] and [[vata]]) along with  the ten factors called dushya i.e, [[medas]], [[rakta]], [[shukra]], body fluid(ambu), muscle fat(vasa), lymph(lasika),[[ majja]], [[rasa]], [[ojas]] and [[mamsa]] play the role.[Cha.Sa. [[Chikitsa Sthana]] 6/8].While considering the prognosis, “Tulyadushyata” (similarity between the characteristics of [[dosha]] and dushya) is a good sign of prognosis[A.S.Sutra Sthana7/218]
  
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Visarpa (acute spreading erysepelas)also has involvement of seven dhatu which determine the prognosis of the condition. [Cha.Sa. Chikitsasthana 21/12]
+
Pathology of skin diseases(kushtha) is related to the deranged physiology of seven factors. They are [[vata]], [[pitta]] and [[kapha]] doshas in aggravated state and dhatus, namely, tvak (since the skin is the organ in which rasa dhatu is present, tvak word is used instead of [[rasa dhatu]]),[[ mamsa]], [[shonita]] and lasika that get deranged due to aggravated [[dosha]]. The involvement of higher dhatu makes the disease more complicated. [Cha.Sa. [[Chikitsa Sthana]] 7/9-10]
  
−
According to Acharya Sushruta, visha(poison) situated in a particular dhatu produces the dhatupradoshajavikara of that particular dhatu.[Su.sa. Kalpasthana 2/30]
+
Acute spreading erysepelas (Visarpa)also has the involvement of seven dhatu which determine the prognosis of the condition. [Cha.Sa. [[Chikitsa Sthana]] 21/12]
  
−
'''Dhatukshaya (degeneration of tissues)''':
+
According to Acharya Sushruta, poison(visha) situated in a particular dhatu produces the dhatupradoshajavikara of that particular dhatu.[Su.sa. Kalpa Sthana 2/30]
 +
 
 +
=== Dhatukshaya (degeneration of tissues) ===
  
 
Dhatukshaya means degeneration or decrement of quality and/or quality of body tissues. It is considered an important event in many disease pathologies.  
 
Dhatukshaya means degeneration or decrement of quality and/or quality of body tissues. It is considered an important event in many disease pathologies.  
  
−
In Rajayakshma (wasting diseases) there is direct relationship to the defect in nourishment of body tissues. The diagnosis and treatment depend upon qualitative and quantitative assessment of dhatu. [Cha.Sa. Nidanasthana 6/ 8-9]
+
In wasting diseases (Rajayakshma) there is direct relation to the defect in the nourishment of body tissues. The diagnosis and treatment depend upon qualitative and quantitative assessment of dhatu. [Cha.Sa. [[Nidana Sthana]] 6/ 8-9]
  
 
Moreover, dhatukshaya is mentioned as the etiology or consequence of different diseases like
 
Moreover, dhatukshaya is mentioned as the etiology or consequence of different diseases like
  
−
• Unmada[Cha.Sa. Chikitsa sthana 9/9]
+
*Unmada[Cha.Sa. [[Chikitsa Sthana]] 9/9]
  
−
• Udara[Cha.Sa. Chikitsa sthana 13/194]
+
*Udara[Cha.Sa. [[Chikitsa Sthana]] 13/194]
  
−
• Pandu [Cha.Sa. Chikitsa sthana 16/5]
+
*Pandu [Cha.Sa. [[Chikitsa Sthana]] 16/5]
  
−
• Hikka, Shwasa[Cha.Sa. Chikitsa sthana 17/82]
+
*Hikka, Shwasa[Cha.Sa. [[Chikitsa Sthana]] 17/82]
  
−
• Kasa[Cha.Sa. Chikitsa sthana 18/153]
+
*Kasa[Cha.Sa. [[Chikitsa Sthana]] 18/153]
  
−
• Chhardi[Cha.Sa. Chikitsa sthana 20/46]
+
*Chhardi[Cha.Sa. [[Chikitsa Sthana]] 20/46]
  
−
• Trushna[Cha.Sa. Chikitsa sthana 22/5]
+
*Trushna[Cha.Sa. [[Chikitsa Sthana]] 22/5]
  
−
• Vatavyadhi [Cha.Sa. Chikitsa sthana 28/59]
+
*Vatavyadhi [Cha.Sa. [[Chikitsa Sthana]] 28/59]
  
−
• Klaibya [Cha.Sa. Chikitsa sthana 30/180]
+
*Klaibya [Cha.Sa. [[Chikitsa Sthana]] 30/180]
  
−
• Marmabhighata- in Kalantarapranahara and VaikalyakaraMarma[Su.Sa. Sharira sthana 6/37-38]
+
*Marmabhighata- in Kalantarapranahara and Vaikalyakara Marma[Su.Sa. Sharira sthana 6/37-38]
  
−
==Importance in preservation of health and prevention: ==
+
== Importance in preservation of health and prevention ==
−
Disequilibrium of dhatu is disease and their equilibrium is health. Health is termed as happiness, while disorder as unhappiness.[Cha.Sa. Sutra sthana 9/4]
 
  
−
In a state of equilibrium of dhatu, diseases are prevented, tissue elements develop properly and ageing process slows down [Cha.Sa. Sutra sthana 7/49].
+
Disequilibrium of dhatu is disease and their equilibrium is health. Health is termed as happiness, while disorder as unhappiness.[Cha.Sa. [[Sutra Sthana]] 9/4]
  
−
==Importance in management of Disease==
+
In a state of equilibrium of dhatu, diseases are prevented, tissue elements develop properly and ageing process slows down [Cha.Sa. [[Sutra Sthana]] 7/49].
−
• While treating the conditions like dhatukshaya or dhatuvrudhi, the principles of “samanya and vishesha” are applied.For example, the mamsa dhatu get increased predominantly with the consumption of meat, rakta by rakta, meda by fat, vasa by muscle fat, asthi by tarunasthi(cartilage), shukra by shukra(semen) and garbha(fetus) by ama garbha, like egg. [Cha. Sa.Sharirasthana 6/10]
 
  
−
• Acharya Sushruta says that dosha get sthiratwa(stability) and mahatwa(severity) when they invade the successive dhatu.It becomes difficult to manage them, when they have invaded the deeper dhatu as in case of a tree with deeper roots. [Su.sa. Sutra sthana 23/15-16]
+
==Importance in management of disease==
  
−
• While planning the treatment of a particular disease, the stage of the disease in terms of involvement of dhatu is important. The concept of koshtha and shakha is important here. In some contexts, the term koshtha is used for rasa dhatu and shakha refers to the succeeding dhatu(rakta, mamsa etc.).
+
*While treating the conditions like dhatukshaya or dhatuvrudhi, the principles of “samanya and vishesha” are applied.For example, the [[mamsa dhatu]] get increased predominantly with the consumption of meat,[[rakta]] by rakta, [[meda]] by fat, vasa by muscle fat, [[asthi]] by cartilage(tarunasthi), [[shukra]] by semen(shukra) and fetus(garbha) by ama garbha, like egg. [Cha. Sa.[[Sharira Sthana]] 6/10]
  
−
Panchakarma procedures are indicated for the elimination of morbid dosha situated in shakha after bringing them back to koshtha. [Su.sa. Chikitasasthana 32/21]
+
*Acharya Sushruta says that dosha get stability(sthiratwa) and severity(mahatwa) when they invade the successive dhatu. It becomes difficult to manage them, when they have invaded the deeper dhatu as in case of a tree with deeper roots. [Su.sa. Sutra sthana 23/15-16]
  
−
• Among the benefits of snehana , the term “pratyagradhatu”(rejuvenation of dhatu)is mentioned.[Su.sa. chikitasasthana 31/56]
+
*While planning the treatment of a particular disease, the stage of the disease in terms of involvement of dhatu is important. The concept of koshtha and shakha is important here. In some contexts, the term koshtha is used for [[rasa dhatu]] and shakha refers to the succeeding dhatu([[rakta]],[[mamsa]] etc.).
  
−
• Among the benefits of shodhanachikitsa , “dhatusthiratwam”(strength in terms of proper formation)is emphasized. [Su.sa. Chikitsasthana 33/27]
+
Panchakarma procedures are indicated for the elimination of morbid [[dosha]] situated in shakha after bringing them back to koshtha. [Su.sa. Chikitsa Sthana 32/21]
  
−
==Current researches: ==
+
*Among the benefits of [[snehana]], rejuvenation of dhatu (pratyagradhatu)is mentioned.[Su.sa. chikitasa Sthana 31/56]
−
National  Seminar  on ‘Rasayana’  opened The New  Indian  Express, News
 
−
article  published  on  Monday,  June  11,  2012
 
  
−
Dhatu and body tissues:
+
*Among the benefits of shodhana chikitsa, strength in terms of proper formation(dhatusthiratwam)is emphasized. [Su.sa. Chikitsa Sthana 33/27]
  
−
In current perspective of human physiology, the seven dhatu correspond to seven kinds of basic tissues as below:
+
== Contemporary approach ==
  
−
Rasa: plasma including interstitial fluid and lymph
+
=== Dhatu and body tissues ===
  
−
Rakta: elements of blood and electrolytes
+
In current perspective of human physiology, the seven dhatu correspond to seven kinds of basic tissues as below:  
  
−
Mamsa: muscle tissue
+
[[Rasa dhatu]]: plasma including interstitial fluid and lymph
  
−
Meda: adipose tissue
+
[[Rakta dhatu]]: elements of blood and electrolytes
  
−
Asthi: bone tissue  
+
[[Mamsa dhatu]]: muscle tissue  
  
−
Shukra: elements of reproductive tissues <ref> Dwarkanath C. Introduction to Kayachikitsa. Chaukhambha Orientalia. Varanasi; 1996. Third edition.pg.318 </ref>
+
[[Meda dhatu]]: adipose tissue
  
−
'''Dhatvagni and tissue metabolism:'''
+
[[Asthi dhatu]]: bone tissue  
  
−
The tissue metabolism corresponds to functions of dhatvagni at various levels as below:<ref>Amardeep Kour, Gupta Vikas, Sodhi Danisha. Importance of Nyayas on Body’s Well-Being – A Conceptual Study. Int J Ayu Pharm Chem 2015 Vol. 4 Issue 1.pg.95-106 available from www.ijapc.com</ref>
+
[[Majja dhatu]]: bone marrow
  
−
Rasa Dhatwagni: Glucose metabolism, circulation in portal vein, formation of WBC
+
[[Shukra dhatu]]: elements of reproductive tissues <ref> Dwarkanath C. Introduction to Kayachikitsa. Chaukhambha Orientalia. Varanasi; 1996. Third edition.pg.318 </ref>
  
−
Raktadhatwagni:Hemopoeisis, iron metabolism, protein metabolism
+
However, the concept of dhatu is much broader than tissues. It includes the components that nourish successor dhatu, metabolic byproducts (upadhatu) and wastes(mala). All three components have importance in maintaining equilibrium in body. Therefore the types of tissues mentioned above can be included in category of dhatu, but it can't be considered as whole dhatu. 
  
−
Mamsadhatwagni: Protein metabolism  
+
=== Dhatvagni and tissue metabolism ===
  
−
Medodhatwagni:Lipid metabolism
+
The tissue metabolism corresponds to functions of dhatvagni at various levels as below:<ref>Amardeep Kour, Gupta Vikas, Sodhi Danisha. Importance of Nyayas on Body’s Well-Being – A Conceptual Study. Int J Ayu Pharm Chem 2015 Vol. 4 Issue 1.pg.95-106 available from www.ijapc.com</ref>
  
−
Asthidhatwagni: Calcium and phosphorous metabolism, thyroid & parathyroid control  
+
#Rasadhatwagni: Glucose metabolism, circulation in portal vein, formation of WBC
 +
#Raktadhatwagni:Hemopoeisis, iron metabolism, protein metabolism
 +
#Mamsadhatwagni: Protein metabolism
 +
#Medodhatwagni: Lipid metabolism
 +
#Asthidhatwagni: Calcium and phosphorous metabolism, thyroid & parathyroid control  
 +
#Majjadhatwagni:Protein metabolism, iron metabolism, hemopoietic and erythroclastic activity
 +
#Sukradhatwagni: Glucose metabolism, protein metabolism, vitamin E metabolism
  
−
Majjadhatwagni:Protein metabolism, iron metabolism, hemopoietic and erythroclastic activity
+
== Current researches ==
  
−
Sukradhatwagni: Glucose metabolism, protein metabolism, vitamin E metabolism
+
=== Stem cells and poshaka dhatu ===
−
 
 
−
'''Stem cells and poshaka dhatu''':
 
  
 
In Ayurveda research field, the concept of rasayana with respect to dhatu and stem cells is initially introduced by Prasad BS <ref>National Seminar on ‘Rasayana’ opened-The New Indian Express, News article published on Monday, June 11. 2012. Available from: http://www.newindianexpress.com/states/kerala/article539215.ece </ref> .On the basis of stem cell type potency, this development is continued throughout life. It is found that the bone marrow contains at least two kinds of stem cells. One population, called hematopoietic stem cells, forms all types of blood cells in the body. A second small population called non-hematopoietic stem cell can generate bone, cartilage, fat and cells that support the formation of blood and fibrous connective tissue (skeletal stem cells).  
 
In Ayurveda research field, the concept of rasayana with respect to dhatu and stem cells is initially introduced by Prasad BS <ref>National Seminar on ‘Rasayana’ opened-The New Indian Express, News article published on Monday, June 11. 2012. Available from: http://www.newindianexpress.com/states/kerala/article539215.ece </ref> .On the basis of stem cell type potency, this development is continued throughout life. It is found that the bone marrow contains at least two kinds of stem cells. One population, called hematopoietic stem cells, forms all types of blood cells in the body. A second small population called non-hematopoietic stem cell can generate bone, cartilage, fat and cells that support the formation of blood and fibrous connective tissue (skeletal stem cells).  
Line 266: Line 310:
 
In some organs, such as the gut and bone marrow, stem cells regularly divide to repair and replace worn out or damaged tissues. In other organs, however, such as the pancreas and the heart, stem cells only divide under special conditions.<ref>Ghaffari S. Cancer, stem cells and cancer stem cells: Old ideas, new developments. F1000 Med Rep. 2011;3:23 </ref> Mesodermal progenitor cells are found throughout the body, they can differentiate to form multiple cell types (e.g. osteocytes, adipocytes, chondrocytes, fibroblasts, and smooth muscle cells) and they have a limited ability to self-renew.<ref>Melero-Martin JM, Dudley AC. Concise review: Vascular stem cells and tumor angiogenesis. Stem Cells. 2011;29:163–8 </ref>  
 
In some organs, such as the gut and bone marrow, stem cells regularly divide to repair and replace worn out or damaged tissues. In other organs, however, such as the pancreas and the heart, stem cells only divide under special conditions.<ref>Ghaffari S. Cancer, stem cells and cancer stem cells: Old ideas, new developments. F1000 Med Rep. 2011;3:23 </ref> Mesodermal progenitor cells are found throughout the body, they can differentiate to form multiple cell types (e.g. osteocytes, adipocytes, chondrocytes, fibroblasts, and smooth muscle cells) and they have a limited ability to self-renew.<ref>Melero-Martin JM, Dudley AC. Concise review: Vascular stem cells and tumor angiogenesis. Stem Cells. 2011;29:163–8 </ref>  
  
−
Rasa Dhatu may have all types of cell differentiate lineage responsible for the development of all saptadhatu, may be known as pluripotent.<ref>Sharma V, Chaudhary AK. Concepts of Dhatu Siddhanta (theory of tissues formation and differentiation) and Rasayana; probable predecessor of stem cell therapy. Ayu. 2014;35(3):231–236. doi:10.4103/0974-8520.153731 </ref>   
+
[[Rasa Dhatu]] may have all types of cell differentiate lineage responsible for the development of all saptadhatu, may be known as pluripotent.<ref name=SharmaV2014>Sharma V, Chaudhary AK. Concepts of Dhatu Siddhanta (theory of tissues formation and differentiation) and Rasayana; probable predecessor of stem cell therapy. Ayu. 2014;35(3):231–236. doi:10.4103/0974-8520.153731 </ref>   
  
 
Recent studies suggest that the spermatogonial stem cells can be reprogrammed to become ES-like cells to acquire pluripotency.<ref>Singh SR, Burnicka-Turek O, Chauhan C, Hou SX. Spermatogonial stem cells, infertility and testicular cancer. J Cell Mol Med. 2011;3(15):468–83 </ref> Wholesome shukradhatu may be considered as pluripotent, because it is responsible for the transmission of genetic information from an individual to the next generation.  
 
Recent studies suggest that the spermatogonial stem cells can be reprogrammed to become ES-like cells to acquire pluripotency.<ref>Singh SR, Burnicka-Turek O, Chauhan C, Hou SX. Spermatogonial stem cells, infertility and testicular cancer. J Cell Mol Med. 2011;3(15):468–83 </ref> Wholesome shukradhatu may be considered as pluripotent, because it is responsible for the transmission of genetic information from an individual to the next generation.  
  
−
Thus, each dhatu carry the potency to regenerate further dhatu, because each avayava (organ) is formed by composition of many dhatus.<ref>Sharma V, Chaudhary AK. Concepts of Dhatu Siddhanta (theory of tissues formation and differentiation) and Rasayana; probable predecessor of stem cell therapy. Ayu. 2014;35(3):231–236. doi:10.4103/0974-8520.153731 </ref>  
+
Thus, each dhatu carry the potency to regenerate further dhatu, because each avayava (organ) is formed by composition of many dhatus.<ref name=SharmaV2014 />  
−
===List of thesis done===
+
 
 +
=== List of theses done===
 +
 
 
1. Upadhyay Vashudev J (2001) :Medo-Dhatvagni ka Sthaulya Roga ke Sandharbha mein Saidhantika evam Prayogika Adhyayana, Department of Basic principles, IPGT&RA,Jamnagar.
 
1. Upadhyay Vashudev J (2001) :Medo-Dhatvagni ka Sthaulya Roga ke Sandharbha mein Saidhantika evam Prayogika Adhyayana, Department of Basic principles, IPGT&RA,Jamnagar.
  
 
2.Kishor G Satani(2011) : An Applied Study of Interrelationship of Jatharagni and Dhatvagni in Context to Dhatuvrddhi, Department of Basic principles, IPGT&RA,Jamnagar.
 
2.Kishor G Satani(2011) : An Applied Study of Interrelationship of Jatharagni and Dhatvagni in Context to Dhatuvrddhi, Department of Basic principles, IPGT&RA,Jamnagar.
  
−
==More information ==
+
== More information ==
−
[[VividhashitapitiyaAdhyaya]]  
+
 
 +
[[Vividhashitapitiya Adhyaya]]  
  
 
[[Rogabhishagjitiya Vimana]]  
 
[[Rogabhishagjitiya Vimana]]  
  
−
[[ShoshaNidana]]  
+
[[Shosha Nidana]]
 +
 
 +
[[Grahani Chikitsa]]
 +
 
 +
=== Related articles ===
 +
 
 +
*[[Rasa dhatu]]
  
−
[[GrahaniChikitsa]]
+
*[[Rakta dhatu]]
  
−
==Table 1: Contextual meanings of the word Dhatu with reference in Charak Samhita ==
+
*[[Mamsa dhatu]]
−
{| class="wikitable"
+
 
−
|-
+
*[[Meda dhatu]]
−
! Sr. No. !! Denoting only Saptadhatu !! As collective term for Dosha-Dhatu-Mala !! Components of Garbha !! Denoting elements like metals
+
 
−
|- 
+
*[[Asthi dhatu]]
−
|  || '''Sutra sthana'''  ||  ||  ||
+
 
−
|-
+
*[[Majja dhatu]]
−
| 1 || Chapter 10 verse 18 || Chapter 1 verse 53 || Chapter 11 verse 23 || --
+
 
−
|-
+
*[[Shukra dhatu]]
−
| 2 || Chapter 18 verse 49 || Chapter 1 verse 67 || Chapter 11 verse 32 || --
+
 
−
|-
+
=== Abbreviations ===
−
| 3 || Chapter 27 verse 62 || Chapter 7 verse 49 || Chapter 25 verse 15 || --
+
 
−
|-
+
*SAT = Standard Ayurveda Terminology
−
| 4 || Chapter 28 verse 3 || Chapter 9 verse 4 || Chapter 25 verse 17 || --
+
*Cha. = Charak
−
|-
+
*Su. = Sushruta
−
| 5 || Chapter 28 verse 4 || Chapter 9 verse 5 || -- || --
+
*Ka. = Kashyapa
−
|-
+
*Sha. =Sharangadhara
−
| 6 || Chapter 28 verse 46 || Chapter 19 verse 5 || -- || --
+
*Sa. = Samhita
−
|-
+
*A.  = Ashtanga
−
| 7 || -- || Chapter 19 verse 6 || -- || --
+
*Hr. = Hridaya
−
|-
+
*S.  = Sangraha
−
| 8 || -- || Chapter 21 verse 42 || -- || --
+
 
−
|-
+
=== List of references in [[Charak Samhita]] ===
−
| 9 || -- || Chapter 27 verse 3 || -- || --
+
 
−
|-
+
The list of references of dhatu observed in Charak Samhita can be downloaded [[Media:Dhatu-_List_of_references.pdf|here]].
−
| 10 || -- || Chapter 27 verse 254 || -- || --
+
 
−
|-
+
<big>'''[[Special:ContactMe|Send us your suggestions and feedback on this page.]]'''</big>
−
| 11 || -- || Chapter 28 verse 4 || -- || --
+
 
−
|-
+
== References ==
−
| || '''Sharira sthana'''  ||  ||  ||
 
−
|-
 
−
| 12 || Chapter 6 verse 10 || Chapter 4 verse 12 || Chapter 1 verse 16 || --
 
−
|-
 
−
| 13 || Chapter 6 verse 11 || Chapter 5 verse 12 || Chapter 5 verse 7 || --
 
−
|-
 
−
| 14 || Chapter 8 verse 31 || Chapter 6 verse 15 || Chapter 5 verse 8 || --
 
−
|-
 
−
| 15 || Chapter 8 verse 49 || Chapter 8 verse 38 || -- || --
 
−
|-
 
−
|  || '''Nidana sthana'''  ||  ||  ||
 
−
|-
 
−
| 16 || Chapter 1 verse 20 || Chapter 4 verse 42 || -- || --
 
−
|-
 
−
| 17 || Chapter 1 verse 23 || -- || -- ||--
 
−
|-
 
−
| 18 || Chapter 1 verse 26 || -- || -- || --
 
−
|-
 
−
| 19 || Chapter 4 verse 43 || -- || -- || --
 
−
|-
 
−
| 20 || Chapter  5 verse 3 || -- || -- || --
 
−
|-
 
−
| 21 || Chapter  6 verse 10 || -- || -- || --
 
−
|-
 
−
|  || '''Vimana sthana'''  ||  ||  ||
 
−
|-
 
−
| 22 || Chapter 5 verse 8 || Chapter 6 verse 3 || -- || --
 
−
|-
 
−
| 23 || Chapter 5 verse 23 || Chapter 8 verse 84 || -- || --
 
−
|-
 
−
| 24 || Chapter 5 verse 25 || Chapter 8 verse 86 || -- || --
 
−
|-
 
−
| 25 || -- || Chapter 8 verse 87 || -- || --
 
−
|-
 
−
| 26 || -- || Chapter 8 verse 122 || -- || --
 
−
|-
 
−
|  || '''Chikitsa sthana'''  ||  ||  ||
 
−
|-
 
−
| 27 || Chapter 3 verse 68 || Chapter 2 part 4 verse 41 || -- || Chapter 1 part 3 verse 48
 
−
|-
 
−
| 28 || Chapter 3 verse 73 || Chapter 3 verse 148 || -- || Chapter 1 part 3 verse 61
 
−
|-
 
−
| 29 || Chapter 3 verse 130 || Chapter 13 verse 194 || -- || Chapter 2 part 1 verse 17
 
−
|-
 
−
| 30 || Chapter 3 verse 148 || Chapter 22 verse 5 || -- || Chapter 7 verse 70
 
−
|-
 
−
| 31 || Chapter 3 verse 244 || Chapter 28 verse 59 || -- || Chapter 16 verse 73
 
−
|-
 
−
| 32 || Chapter 3 verse 276 || Chapter 30 verse 151 || -- || Chapter 26 verse 250
 
−
|-
 
−
| 33 || Chapter 3 verse 336 || Chapter 30 verse 180 || -- || Chapter 30 verse 3
 
−
|-
 
−
| 34 || Chapter 4 verse 8 || -- || -- || --
 
−
|-
 
−
| 35 || Chapter 4 verse 8 || -- || -- || --
 
−
|-
 
−
| 36 || Chapter 6 verse 11 || -- || -- || --
 
−
|-
 
−
| 37 || Chapter 8 verse 39 || -- || -- || --
 
−
|-
 
−
| 38 || Chapter 8 verse 42 || -- || -- || --
 
−
|-
 
−
| 39 || Chapter 8 verse 167 || -- || -- || --
 
−
|-
 
−
| 40 || Chapter 9 verse 9 || -- || -- || --
 
−
|-
 
−
| 41 || Chapter 15 verse 20 || -- || -- || --
 
−
|-
 
−
| 42 || Chapter 15 verse 36 || -- || -- || --
 
−
|-
 
−
| 43 || Chapter 15 verse 50 || -- || -- || --
 
−
|-
 
−
| 44 || Chapter 15 verse 246 || -- || -- || --
 
−
|-
 
−
| 45 || Chapter 17 verse 82 || -- || -- || --
 
−
|-
 
−
| 46 || Chapter 18 verse 153 || -- || -- || --
 
−
|-
 
−
| 47 || Chapter 19 verse 9 || -- || -- || --
 
−
|-
 
−
| 48 || Chapter 20 verse 46 || -- || -- || --
 
−
|-
 
−
| 49 || Chapter 21 verse 8 || -- || -- || --
 
−
|-
 
−
| 50 || Chapter 21 verse 12 || -- || -- || --
 
−
|-
 
−
| 51 || Chapter 23 verse 175 || -- || -- || --
 
−
|-
 
−
| 52 || Chapter 30 verse 184 || -- || -- || --
 
−
|-
 
−
|  || '''Sidhi sthana'''  ||  ||  ||
 
−
|-
 
−
| 53 || Chapter 1 verse 59 || Chapter 10 verse 7 || -- ||--
 
−
|-
 
−
|}
 
  
−
References:
+
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Latest revision as of 19:23, 23 February 2024

Cite.png

Dhatu means body constituents which build the basic structure and carry various physiological functions. They work as body tissues, stabilize and sustain body. (Code:SAT-B.425)[1] The structural and functional integrity of body depends upon dhatu. Therefore, it is important to understand the concept of dhatu.
In physics and chemistry, the term dhatu is applied to denote metals like iron, copper etc. In Sanskrit grammar, the term is applied to denote root verb and derivation.

Contributors
Section/Chapter/topic Sharira / Dhatu
Authors Anagha S., Deole Y.S.
Reviewer and Editor Basisht G.
Affiliations Charak Samhita Research, Training and Development Centre, I.P.G.T.& R.A., Jamnagar
Correspondence email carakasamhita@gmail.com
Publisher Charak Samhita Research, Training and Development Centre, I.T.R.A., Jamnagar, India
Date of first publication: April 16, 2020
DOI 10.47468/CSNE.2020.e01.s09.012

Etymology and derivation

The word ‘dhatu’ is derived from the word root “Dha” by adding suffix “Tun”. The derivation of the word is as follows-

“डु धाञ धारणपोषणयोः”- meaning that which sustains and nourishes.

In general, the Sanskrit word conveys the meaning of a component, constituent, elementary substance, verbal, grammatical root or a metal.[2]

Synonyms

When these physiological constituents are affected by dosha and lead to abnormalities, they are termed as dushya. [A.Hr. Sutra Sthana 1/13]

Meanings in different contexts

In Charak Samhita, the word dhatu is used in different contexts as follows.

  • Seven structural components(Sapta dhatu)[Table1]
  • Denoting any bodily element/anatomical structure[Cha. Sa. Sharira Sthana 5/12]
  • Denoting the components of garbha(Shad dhatu) [Table1]
  • metals(Loha) [Table1]

Special Considerations

  • Beejarupa dhatu- denoting sperm- containing the essence of all seven dhatu of man(shukra) [Cha. Sa. Sharira Sthana 4/7,10]
  • Apdhatu- denoting watery elements in body [Cha. Sa. Chikitsa Sthana 22/11,13,21]
  • Dhatu term denoting any product (karyadravya)[Cha. Sa. Sutra Sthana 12/8]

Seven dhatu

The term generally refers to the seven structural components of the body.

They are as below:

  1. Rasa dhatu: plasma and lymph
  1. Rakta dhatu: blood tissue
  1. Mamsa dhatu: muscle tissue
  1. Meda dhatu: adipose tissue
  1. Asthi dhatu: bone tissue
  1. Majja dhatu: bone marrow
  1. Shukra dhatu: reproductive fluids; semen

Three dhatu

Three dosha are termed as dhatu as they are responsible for maintaining body functions.

  1. Vata
  2. Pitta
  3. Kapha [Cha. Sa. Chikitsa Sthana 3/73]

Six dhatu

These are the components of embryo(garbha) including panchamahabhuta and atma. [Cha. Sa. Sharira Sthana 1/16]

It denotes the combination of akasha, vayu, Agni, jala, prithvi(i.e. the five elements) and soul(atma).

Eight dhatu

These are components of prakriti. [Cha. Sa. Sharira Sthana 1/17]

It consists of five mahabhuta (in their subtle form), ego (ahamkara), intellect(mahat), and primordial element(avyakta).

Twenty four dhatu

These are 24 components of purusha. [Cha. Sa. Sharira Sthana 1/17]

Purusha comprises of twenty-four dhatu, i.e. mind, ten sensory and motor organs (indriya), five objects of sense organs, and prakriti (consisting of eight dhatu).

Formation and nourishment of dhatu

The dhatu are formed from first transformed food into nutrient fluid called ahara-rasa (prasada). This nutrient fluid nourishes body components in a sequential pattern. It first nourishes the rasa dhatu, then rakta, then mamsa etc. The nutrients present in the food nourish respective dhatu qualitatively and quantitatively. [Cha. Sa. Sutra Sthana 28/4]

Furthermore, during the process of metabolism, dhatus undergo a specific pathway through their own characteristic digestive enzymes termed as ‘dhatvagni. In this process, each dhatu gets converted into two parts: poshya(which nourishes itself) and poshaka (which nourishes others). The poshya fraction is responsible for dhatu’s own nourishment and functions. The poshaka fraction nourishes further other dhatus.

By-products(Upadhatu) and waste products(mala) are also formed in this dhatu metabolic process.

Thus, each dhatu nourishes its next sequential dhatu.[Cha. Sa.Chikitsa Sthana 8/39]

Functions of Dhatu

The major functions of seven dhatus are listed as nourishment(preenana), vitalizing(jeevana), covering(lepa), moistening(snehana), supporting(dharana),filling(poorana), and reproduction(garbhoptpadana) respectively.[A.Hr. sutra sthana 9/4]

Sr. No. Dhatu qualities (Guna) functions(Karma)
1 Rasa dhatu Drava, snigdha, sara, manda satiety (Tushti), nourishment(Preenan), nourishing blood (Raktapushti)
2 Rakta dhatu Drava, sara, visra, laghu vitality (Jeevana), complexion(Varnaprasadana), nourishing muscles (Mamsapushti)
3 Mamsa dhatu Sthira, guru, snigdha, pichila nourishing body (Dehapushti), body mass (Lepa) ,nourishing adipose tissue(medapushti)
4 Meda dhatu Snigdha, guru,shlakshna, mrudu, Sandra oleation (Snehana) of eyes and body,firmness(drudhatwa), nourishing bones (asthipushti)
5 Asthi dhatu Sthira,guru, kathina, khara holding body frame(Dharana), nourishing bone marrow (Majjapushti)
6 Majja dhatu Sandra, drava, snigdha,shlakshna oleation (Snehana), strength(Balakara), filling up bones(Asthipoorana), nourishing reproductive tissues (Shukrapushti)
7 Shukra dhatu Drava, sheeta, snigdha pleasure (Harsha), strength (Bala), reproduction(Garbhotpadana)

Concept of Upadhatu and Dhatumala

Upadhatu and mala are by-products formed during the process of metabolism. The by-products are categorized into these two groups according to their functional importance. Dhatu supports the body and nourishes the subsequent dhatu. However,upadhatus do not nourish any further element. They only carry physiological functions and only support the body.

The other by-products are dhatu-mala or excretory products. They can get easily vitiated by pathogenic factors; hence they are termed as mala. The following table gives information about upadhatu and mala. [Cha. Sa.Chikitsa Sthana 15/17], [Cha.Sa. Chikitsa Sthana 15/20]

Sr. No. Dhatu Upadhatu Mala
1. Rasa breast milk (Stanya), menstrual blood(Rakta) Kapha
2. Rakta artery (Kandara), blood vessels (sira), menstrual blood(artava)* Pitta
3. Mamsa muscle fat (Vasa), six layers of skin excreta in ear, nose etc.(Kha-mala )
4. Meda tendons (Snayu) sweat (Sweda)
5. Asthi teeth(Danta)*nails(nakha)# scalp hair(Kesha) and body hair(loma)
6. Majja hair(Kesha)* oiliness in eyes, skin and stools(Akshi-twacha-vit sneha)
7. Shukra Ojas* --
  • *As opined by Sharangadhara[Sha.Sa. Purvakhanda chapter 5], # As opined by Sushruta [Su.Sa. Sutra Sthana 46/529]

Importance of knowledge of dhatu in clinical diagnosis and treatment

Assessment of sara (excellent quality of dhatu)

Sara means the excellent quality of dhatu. It is highly related with the health of tissue and endurance to pathogens. The excellent quality depends upon metabolism(dhatvagni). It is one of the assessment parameters to determine strength of an individual in ten-fold examination. The individuals are categorized on the basis of predominance of a particular dhatu as twaksara, raktasara, mamsasara, medosara, asthisara, majjasara and shukrasara. [Cha.Sa. Vimana Sthana 8/102]

Importance in diagnosis

Dhatu have their respective systems(srotas). These srotas get affected due to the vitiation of dosha and lead to diseases. Thus, dhatu are the site of lesion in view of diagnosis and target receptors in view of treatment.

The increase or decrease of dhatu is also assessed for diagnosis of specific disease. The vitiated dosha reside in dhatu and produce specific clinical features as observed in the conditions of jwara and kushtha.

In view of prognosis, the involvement of a particular dhatu has importance in prognosis also.

In jwara, if doshas are located in rasa, rakta,mamsa and medas dhatu, the conditionsare curable; while if those are located in the asthi and majja dhatu, then conditions are difficult to treat. If vitiated dosha are located in shukra dhatu, the condition is incurable. [Cha.Sa. Chikitsa Sthana 3/75-83]

In the pathogenesis of obstinate urinary disorders(prameha) dosha ( kapha, pitta and vata) along with the ten factors called dushya i.e, medas, rakta, shukra, body fluid(ambu), muscle fat(vasa), lymph(lasika),majja, rasa, ojas and mamsa play the role.[Cha.Sa. Chikitsa Sthana 6/8].While considering the prognosis, “Tulyadushyata” (similarity between the characteristics of dosha and dushya) is a good sign of prognosis[A.S.Sutra Sthana7/218]

Pathology of skin diseases(kushtha) is related to the deranged physiology of seven factors. They are vata, pitta and kapha doshas in aggravated state and dhatus, namely, tvak (since the skin is the organ in which rasa dhatu is present, tvak word is used instead of rasa dhatu),mamsa, shonita and lasika that get deranged due to aggravated dosha. The involvement of higher dhatu makes the disease more complicated. [Cha.Sa. Chikitsa Sthana 7/9-10]

Acute spreading erysepelas (Visarpa)also has the involvement of seven dhatu which determine the prognosis of the condition. [Cha.Sa. Chikitsa Sthana 21/12]

According to Acharya Sushruta, poison(visha) situated in a particular dhatu produces the dhatupradoshajavikara of that particular dhatu.[Su.sa. Kalpa Sthana 2/30]

Dhatukshaya (degeneration of tissues)

Dhatukshaya means degeneration or decrement of quality and/or quality of body tissues. It is considered an important event in many disease pathologies.

In wasting diseases (Rajayakshma) there is direct relation to the defect in the nourishment of body tissues. The diagnosis and treatment depend upon qualitative and quantitative assessment of dhatu. [Cha.Sa. Nidana Sthana 6/ 8-9]

Moreover, dhatukshaya is mentioned as the etiology or consequence of different diseases like

  • Marmabhighata- in Kalantarapranahara and Vaikalyakara Marma[Su.Sa. Sharira sthana 6/37-38]

Importance in preservation of health and prevention

Disequilibrium of dhatu is disease and their equilibrium is health. Health is termed as happiness, while disorder as unhappiness.[Cha.Sa. Sutra Sthana 9/4]

In a state of equilibrium of dhatu, diseases are prevented, tissue elements develop properly and ageing process slows down [Cha.Sa. Sutra Sthana 7/49].

Importance in management of disease

  • While treating the conditions like dhatukshaya or dhatuvrudhi, the principles of “samanya and vishesha” are applied.For example, the mamsa dhatu get increased predominantly with the consumption of meat,rakta by rakta, meda by fat, vasa by muscle fat, asthi by cartilage(tarunasthi), shukra by semen(shukra) and fetus(garbha) by ama garbha, like egg. [Cha. Sa.Sharira Sthana 6/10]
  • Acharya Sushruta says that dosha get stability(sthiratwa) and severity(mahatwa) when they invade the successive dhatu. It becomes difficult to manage them, when they have invaded the deeper dhatu as in case of a tree with deeper roots. [Su.sa. Sutra sthana 23/15-16]
  • While planning the treatment of a particular disease, the stage of the disease in terms of involvement of dhatu is important. The concept of koshtha and shakha is important here. In some contexts, the term koshtha is used for rasa dhatu and shakha refers to the succeeding dhatu(rakta,mamsa etc.).

Panchakarma procedures are indicated for the elimination of morbid dosha situated in shakha after bringing them back to koshtha. [Su.sa. Chikitsa Sthana 32/21]

  • Among the benefits of snehana, rejuvenation of dhatu (pratyagradhatu)is mentioned.[Su.sa. chikitasa Sthana 31/56]
  • Among the benefits of shodhana chikitsa, strength in terms of proper formation(dhatusthiratwam)is emphasized. [Su.sa. Chikitsa Sthana 33/27]

Contemporary approach

Dhatu and body tissues

In current perspective of human physiology, the seven dhatu correspond to seven kinds of basic tissues as below:

Rasa dhatu: plasma including interstitial fluid and lymph

Rakta dhatu: elements of blood and electrolytes

Mamsa dhatu: muscle tissue

Meda dhatu: adipose tissue

Asthi dhatu: bone tissue

Majja dhatu: bone marrow

Shukra dhatu: elements of reproductive tissues [3]

However, the concept of dhatu is much broader than tissues. It includes the components that nourish successor dhatu, metabolic byproducts (upadhatu) and wastes(mala). All three components have importance in maintaining equilibrium in body. Therefore the types of tissues mentioned above can be included in category of dhatu, but it can't be considered as whole dhatu.

Dhatvagni and tissue metabolism

The tissue metabolism corresponds to functions of dhatvagni at various levels as below:[4]

  1. Rasadhatwagni: Glucose metabolism, circulation in portal vein, formation of WBC
  2. Raktadhatwagni:Hemopoeisis, iron metabolism, protein metabolism
  3. Mamsadhatwagni: Protein metabolism
  4. Medodhatwagni: Lipid metabolism
  5. Asthidhatwagni: Calcium and phosphorous metabolism, thyroid & parathyroid control
  6. Majjadhatwagni:Protein metabolism, iron metabolism, hemopoietic and erythroclastic activity
  7. Sukradhatwagni: Glucose metabolism, protein metabolism, vitamin E metabolism

Current researches

Stem cells and poshaka dhatu

In Ayurveda research field, the concept of rasayana with respect to dhatu and stem cells is initially introduced by Prasad BS [5] .On the basis of stem cell type potency, this development is continued throughout life. It is found that the bone marrow contains at least two kinds of stem cells. One population, called hematopoietic stem cells, forms all types of blood cells in the body. A second small population called non-hematopoietic stem cell can generate bone, cartilage, fat and cells that support the formation of blood and fibrous connective tissue (skeletal stem cells).

In some organs, such as the gut and bone marrow, stem cells regularly divide to repair and replace worn out or damaged tissues. In other organs, however, such as the pancreas and the heart, stem cells only divide under special conditions.[6] Mesodermal progenitor cells are found throughout the body, they can differentiate to form multiple cell types (e.g. osteocytes, adipocytes, chondrocytes, fibroblasts, and smooth muscle cells) and they have a limited ability to self-renew.[7]

Rasa Dhatu may have all types of cell differentiate lineage responsible for the development of all saptadhatu, may be known as pluripotent.[8]

Recent studies suggest that the spermatogonial stem cells can be reprogrammed to become ES-like cells to acquire pluripotency.[9] Wholesome shukradhatu may be considered as pluripotent, because it is responsible for the transmission of genetic information from an individual to the next generation.

Thus, each dhatu carry the potency to regenerate further dhatu, because each avayava (organ) is formed by composition of many dhatus.[8]

List of theses done

1. Upadhyay Vashudev J (2001) :Medo-Dhatvagni ka Sthaulya Roga ke Sandharbha mein Saidhantika evam Prayogika Adhyayana, Department of Basic principles, IPGT&RA,Jamnagar.

2.Kishor G Satani(2011) : An Applied Study of Interrelationship of Jatharagni and Dhatvagni in Context to Dhatuvrddhi, Department of Basic principles, IPGT&RA,Jamnagar.

More information

Vividhashitapitiya Adhyaya

Rogabhishagjitiya Vimana

Shosha Nidana

Grahani Chikitsa

Related articles

Abbreviations

  • SAT = Standard Ayurveda Terminology
  • Cha. = Charak
  • Su. = Sushruta
  • Ka. = Kashyapa
  • Sha. =Sharangadhara
  • Sa. = Samhita
  • A. = Ashtanga
  • Hr. = Hridaya
  • S. = Sangraha

List of references in Charak Samhita

The list of references of dhatu observed in Charak Samhita can be downloaded here.

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References

  1. ↑ National AYUSH Morbidity and Standardized Terminologies Electronic Portal by Ministry of AYUSH Available on http://namstp.ayush.gov.in/#/sat
  2. ↑ https://www.sanskrit-lexicon.uni-koeln.de/scans/MWScan/2014/web/webtc/indexcaller.php
  3. ↑ Dwarkanath C. Introduction to Kayachikitsa. Chaukhambha Orientalia. Varanasi; 1996. Third edition.pg.318
  4. ↑ Amardeep Kour, Gupta Vikas, Sodhi Danisha. Importance of Nyayas on Body’s Well-Being – A Conceptual Study. Int J Ayu Pharm Chem 2015 Vol. 4 Issue 1.pg.95-106 available from www.ijapc.com
  5. ↑ National Seminar on ‘Rasayana’ opened-The New Indian Express, News article published on Monday, June 11. 2012. Available from: http://www.newindianexpress.com/states/kerala/article539215.ece
  6. ↑ Ghaffari S. Cancer, stem cells and cancer stem cells: Old ideas, new developments. F1000 Med Rep. 2011;3:23
  7. ↑ Melero-Martin JM, Dudley AC. Concise review: Vascular stem cells and tumor angiogenesis. Stem Cells. 2011;29:163–8
  8. ↑ 8.0 8.1 Sharma V, Chaudhary AK. Concepts of Dhatu Siddhanta (theory of tissues formation and differentiation) and Rasayana; probable predecessor of stem cell therapy. Ayu. 2014;35(3):231–236. doi:10.4103/0974-8520.153731
  9. ↑ Singh SR, Burnicka-Turek O, Chauhan C, Hou SX. Spermatogonial stem cells, infertility and testicular cancer. J Cell Mol Med. 2011;3(15):468–83
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