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Dhatvagni means the factors responsible for metabolism at the level of each [[dhatu]].
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|description=Dhatvagni means the factors responsible for metabolism at the level of each dhatu.
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[[Agni]] is a responsible factor for digestion, transformation, and metabolism in the body. The term ‘dhatvagni’ means the fraction of [[agni]] that functions at various body components ([[dhatu]]) for nourishment and metabolism. It is responsible for the metabolic transformation of food consumed and its assimilation. [[Agni]] is the supreme physiological authority in the human body<ref>A. C. Bhaktivedanta Swami Prabhupāda, 1972. Bhagavad-gītā as it is. Purushottama Yoga, Chapter 15, Shloka No. 14, New York: Bhaktivedanta Book Trust, Page No.517</ref> and is of 13 types. Jatharagni is for digestion, five bhootagni for metabolism of [[panchamahabhuta]] components, and seven dhatvagni for metabolism of [[dhatu]] or tissues.[Chakrapani on Cha.Sa.[[Chikitsa Sthana]] 15] The dhatvagni assimilates and synthesizes the [[dhatu]] or tissues of the human body. It is located in the respective [[strotas]] of the particular [[dhatu]].<ref>Dhargalkar Nandini, Sarira Kriya Vidnana- A textbook of Physiology in Ayurveda, Packagni-Jatharagni,Acchapittam,Bhutagni,Dhatvagni, Part 2, Second edition 2010, Chaukhamba Sanskrit Series Office,Varanasi, Page No.123</ref> Dhatvagni is responsible for the transformation of one [[dhatu]] into another.<ref>NAMASTE - Portal [Internet]. [cited 2022 Jul 9]. Available from: http://namstp.ayush.gov.in/#/sat</ref> This article describes the concept and applications of dhatvagni in medical sciences.
{{Infobox
|title = Dhatvagni
|label1 = Section/Chapter/topic
|data1 = Concepts / [[Agni]]/ [[Dhatvagni]]
|label2 = Authors
|data2 = Bhojani M.K.<sup>1</sup>, Sharma Raksha <sup>1</sup>, Joglekar A.A.<sup>2</sup>
|label3 = Reviewer
|data3 = Basisht G.<sup>3</sup>
|label4 = Editor
|data4 = Deole Y.S.<sup>4</sup>
|label5 = Affiliations
|data5 = <sup>1</sup> Department of Kriya Sharira, All India Institute of Ayurveda, New Delhi, India , New Delhi, India
<sup>2</sup>Department of Samhita Siddhant, All India Institute of Ayurveda, New Delhi, India, New Delhi, India
<sup>3</sup> Rheumatologist, Orlando, Florida, U.S.A.
<sup>4</sup>Department of Kayachikitsa, G.J. Patel Institute of Ayurvedic Studies and Research, New Vallabh Vidyanagar, Anand, Gujarat, India
|label6 = Correspondence email
|data6 = meera.samhita@aiia.gov.in, carakasamhita@gmail.com
|label7 = Publisher
|data7 = [[Charak Samhita Research, Training and Development Centre]], I.T.R.A., Jamnagar, India
|label8 = Date of first publication:
|data8 = September 18, 2022
|label9 = DOI
|data9 = In process
}}
==Synonyms==
Dhatu-ushma [Cha.Sa.[[Chikitsa Sthana]] 8/39-40], dhatupaktru [Cha.Sa.[[Chikitsa Sthana]] 15/38], dhatupakta, dhatupachaka Agni [A.S.Sutra Sthana 19/16]<ref name= Sangraha> Vridha Vagbhata, Ashtanga Sangraha. Edited by Shivaprasad Sharma. 3rd ed. Varanasi: Chaukhamba sanskrit series office;2012.</ref>
==Classification==
The management of diseases depends on correction of [[agni]] and restoration of well-formed [[dhatu]]. [Chakrapani on Cha.Sa.[[Sutra Sthana]] 30/28]. The dhatvagni is classified into seven types as below:
*Rasa dhatvagni
*Rakta dhatvagni
*Mamsa dhatvagni
*Meda dhatvagni
*Asthi dhatvagni
*Majja dhatvagni
*Shukra dhatvagni
==Physiology of dhatvagni==
[[Dhatus]] are the structural and functional units that act as [[dosha]] and [[mala]] seats. The functioning of dhatvagni (dhatvagnipaaka) includes overall nourishment and development of the body structures. Dhatvagnipaaka refers to the sequential changes undergone by the essence of food through the medium of seven dhatvagni entities.
The seven dhatvagni act upon the respective [[dhatu]] by which each [[dhatu]] is metabolized into two parts i.e., essence (prasadabhaga) and by-products (mala bhaga). [Chakrapani on Cha.Sa.[[Chikitsa Sthana]] 15/15] [[Dhatu]] is metabolized by their inherent heat (ushma) or dhatvagni (transforming enzymes in the tissue elements). The nourishing fraction of [[dhatu]] (nutrient tissue elements) further nourishes the subsequent [[dhatu]] through their respective [[strotas]] (channels of circulation). For example, a poshaka [[rasa dhatu]] nourishes the [[rakta dhatu]].[Cha.Sa.[[Chikitsa Sthana]] 8/39] In this process, the formation of essence (prasad bhaga) can be correlated with anabolic pathways. The formation of metabolic wastes or by-products (kitta-paka) can be correlated with catabolic pathways.
The cell can carry on the metabolic process with the aid of enzymes (agnipitta), which are organic catalysts. A catalyst regulates the rate of a chemical reaction's acceleration without change in itself. Few enzymes, such as the digestive enzymes (comparable with jatharaagni), function outside the cell. Most enzymes are intracellular (comparable to dhatvagni and bhutagni). Enzyme oxidation that catalyzes an oxidation-reduction process is termed as ‘oxidase’. An enzyme concerned with the digestion of protein is a protease.<ref>Robinson PK. Enzymes: principles and biotechnological applications. Essays Biochem. 2015;59:1-41. doi: 10.1042/bse0590001. Erratum in: Essays Biochem. 2015;59:75. PMID: 26504249; PMCID: PMC4692135.</ref> This intracellular and extracellular metabolism can be perceived as the dhatvagnipaka.
'''Role of dhatvagni in pathogenesis:'''
The jatharagni essentially nourishes the respective [[dhatu]] in the form of dhatvagni residing in each of the [[dhatu]]. [A.H.Sutra Sthana 11/34]<ref name= Hridaya > Vagbhata. Ashtanga Hridayam. Edited by Harishastri Paradkar Vaidya. 1st ed. Varanasi: Krishnadas Academy;2000.</ref> The dhatvagni is responsible for the increase (vriddhi)/ decrease (kshaya) of the representative [[dhatu]]. The hypo functioning (saada) of the dhatvagni leads to the increase in the respective [[dhatu]]. While hyper functioning (atideepti) leads to diminished production (kshaya) of the [[dhatu]]. Thus, every [[dhatu]]'s metabolism depends on the functions of the dhatvagni, preceding and subsequent [[dhatu]].
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