Changes

'''Association of Gut Microbe with prakriti phenotype:''' Studies discovered gut microbial patterns linked to a variety of host characteristics such as geography, age, and food. A few bacterial taxa were found to be specifically enriched in certain prakriti in recent scientific research. Chauhan et al.<ref>Chauhan NS, Pandey R, Mondal AK, Gupta S, Verma MK, Jain S, et al. Western Indian rural gut microbial diversity in extreme prakriti endo-phenotypes reveals signature microbes. Front Microbiol 2018;9:118.</ref> and Chaudhari et al.<ref>Chaudhari D, Dhotre D, Agarwal D, Gondhali A, Nagarkar A, Lad V, et al. Understanding the association between the human gut, oral and skin microbiome and the Ayurvedic concept of prakriti. J Biosci 2019;44: 112.</ref> detected extreme prakriti phenotypes (vata, pitta, and kapha) in a population from the VHDSS area in Pune and investigated if prakriti phenotyping can serve as a potential stratifier of the gut microbiota in that community and form the basis of personalized medicine.

'''Association of Gut Microbe with prakriti phenotype:''' Studies discovered gut microbial patterns linked to a variety of host characteristics such as geography, age, and food. A few bacterial taxa were found to be specifically enriched in certain prakriti in recent scientific research. Chauhan et al.<ref>Chauhan NS, Pandey R, Mondal AK, Gupta S, Verma MK, Jain S, et al. Western Indian rural gut microbial diversity in extreme prakriti endo-phenotypes reveals signature microbes. Front Microbiol 2018;9:118.</ref> and Chaudhari et al.<ref>Chaudhari D, Dhotre D, Agarwal D, Gondhali A, Nagarkar A, Lad V, et al. Understanding the association between the human gut, oral and skin microbiome and the Ayurvedic concept of prakriti. J Biosci 2019;44: 112.</ref> detected extreme prakriti phenotypes (vata, pitta, and kapha) in a population from the VHDSS area in Pune and investigated if prakriti phenotyping can serve as a potential stratifier of the gut microbiota in that community and form the basis of personalized medicine.

'''Cosmetology and prakriti:''' The use of prakriti in cosmetic science aids in the selection of the appropriate cosmetic formulation; otherwise, cosmetic use at random can have a negative impact on beauty. The skin of healthy individuals with [[vata]] and [[pitta]] dominant prakriti was found to be dehydrated, but hydration was preserved in [[kapha]] dominant prakriti people.<ref>14. Suwarna UV, Deepak VM , Sheela KB, Kalpana SD. Variation in skin hydration on the basis of Deha Prakriti (body constitution): A cross-sectional observational study. Ayu2018;39:127-31.</ref>

'''Cosmetology and prakriti:''' The use of prakriti in cosmetic science aids in the selection of the appropriate cosmetic formulation; otherwise, cosmetic use at random can have a negative impact on beauty. The skin of healthy individuals with [[vata]] and [[pitta]] dominant prakriti was found to be dehydrated, but hydration was preserved in [[kapha]] dominant prakriti people.<ref>Suwarna UV, Deepak VM , Sheela KB, Kalpana SD. Variation in skin hydration on the basis of Deha Prakriti (body constitution): A cross-sectional observational study. Ayu2018;39:127-31.</ref>

'''Genomic and biochemical basis of constitutional:''' Individuals with the three most dissimilar constitutional types have notable variances in biochemical and hematological markers, as well as gene expression levels across the genome.<ref name= Prasher/> The differences in hemoglobin levels between the prakriti are correlated with higher expression of genes that regulate hemoglobin levels, such as HBA1, HBB, and NOV, in [[pitta]] compared to [[vata]] and [[kapha]]. The human leukocyte antigen (HLA) gene polymorphism has been found to have a reasonable connection with prakriti type.<ref>Patwardhan, B.; Joshi, K.; Chopra, A. Classification of Human Population Based on HLA Gene Polymorphism and the Concept of Prakriti in Ayurveda. J. Altern. Complement. Med. 2005, 11, 349–353.</ref> Individuals with [[pitta]] prakriti are observed to have phosphoglucomutase 1 gene.<ref>Govindaraj, P.; Nizamuddin, S.; Sharath, A.; Jyothi, V.; Rotti, H.; Raval, R.; Nayak, J.; Bhat, B.K.; Prasanna, B.V.; Shintre, P.; et al. Genome-wide Analysis Correlates Ayurveda Prakriti. Sci. Rep. 2015, 5, 15786</ref>

'''Genomic and biochemical basis of constitutional:''' Individuals with the three most dissimilar constitutional types have notable variances in biochemical and hematological markers, as well as gene expression levels across the genome.<ref name= Prasher/> The differences in hemoglobin levels between the prakriti are correlated with higher expression of genes that regulate hemoglobin levels, such as HBA1, HBB, and NOV, in [[pitta]] compared to [[vata]] and [[kapha]]. The human leukocyte antigen (HLA) gene polymorphism has been found to have a reasonable connection with prakriti type.<ref>Patwardhan, B.; Joshi, K.; Chopra, A. Classification of Human Population Based on HLA Gene Polymorphism and the Concept of Prakriti in Ayurveda. J. Altern. Complement. Med. 2005, 11, 349–353.</ref> Individuals with [[pitta]] prakriti are observed to have phosphoglucomutase 1 gene.<ref>Govindaraj, P.; Nizamuddin, S.; Sharath, A.; Jyothi, V.; Rotti, H.; Raval, R.; Nayak, J.; Bhat, B.K.; Prasanna, B.V.; Shintre, P.; et al. Genome-wide Analysis Correlates Ayurveda Prakriti. Sci. Rep. 2015, 5, 15786</ref>