Changes

'''Cosmetology and prakriti:''' The use of prakriti in cosmetic science aids in the selection of the appropriate cosmetic formulation; otherwise, cosmetic use at random can have a negative impact on beauty. The skin of healthy individuals with [[vata]] and [[pitta]] dominant prakriti was found to be dehydrated, but hydration was preserved in [[kapha]] dominant prakriti people.<ref>14. Suwarna UV, Deepak VM , Sheela KB, Kalpana SD. Variation in skin hydration on the basis of Deha Prakriti (body constitution): A cross-sectional observational study. Ayu2018;39:127-31.</ref>

'''Cosmetology and prakriti:''' The use of prakriti in cosmetic science aids in the selection of the appropriate cosmetic formulation; otherwise, cosmetic use at random can have a negative impact on beauty. The skin of healthy individuals with [[vata]] and [[pitta]] dominant prakriti was found to be dehydrated, but hydration was preserved in [[kapha]] dominant prakriti people.<ref>14. Suwarna UV, Deepak VM , Sheela KB, Kalpana SD. Variation in skin hydration on the basis of Deha Prakriti (body constitution): A cross-sectional observational study. Ayu2018;39:127-31.</ref>

'''Genomic and biochemical basis of constitutional:''' Individuals with the three most dissimilar constitutional types have notable variances in biochemical and hematological markers, as well as gene expression levels across the genome.<ref name= Prasher/> The differences in hemoglobin levels between the prakriti are correlated with higher expression of genes that regulate hemoglobin levels, such as HBA1, HBB, and NOV, in [[pitta]] compared to [[vata]] and [[kapha]]. The human leukocyte antigen (HLA) gene polymorphism has been found to have a reasonable connection with prakriti type.<ref>Patwardhan, B.; Joshi, K.; Chopra, A. Classification of Human Population Based on HLA Gene Polymorphism and the Concept of Prakriti in Ayurveda. J. Altern. Complement. Med. 2005, 11, 349–353.</ref> Individuals with [[pitta]] prakriti are observed to have phosphoglucomutase 1 gene.<ref>16. Govindaraj, P.; Nizamuddin, S.; Sharath, A.; Jyothi, V.; Rotti, H.; Raval, R.; Nayak, J.; Bhat, B.K.; Prasanna, B.V.; Shintre, P.; et al. Genome-wide Analysis Correlates Ayurveda Prakriti. Sci. Rep. 2015, 5, 15786</ref>

'''Genomic and biochemical basis of constitutional:''' Individuals with the three most dissimilar constitutional types have notable variances in biochemical and hematological markers, as well as gene expression levels across the genome.<ref name= Prasher/> The differences in hemoglobin levels between the prakriti are correlated with higher expression of genes that regulate hemoglobin levels, such as HBA1, HBB, and NOV, in [[pitta]] compared to [[vata]] and [[kapha]]. The human leukocyte antigen (HLA) gene polymorphism has been found to have a reasonable connection with prakriti type.<ref>Patwardhan, B.; Joshi, K.; Chopra, A. Classification of Human Population Based on HLA Gene Polymorphism and the Concept of Prakriti in Ayurveda. J. Altern. Complement. Med. 2005, 11, 349–353.</ref> Individuals with [[pitta]] prakriti are observed to have phosphoglucomutase 1 gene.<ref>Govindaraj, P.; Nizamuddin, S.; Sharath, A.; Jyothi, V.; Rotti, H.; Raval, R.; Nayak, J.; Bhat, B.K.; Prasanna, B.V.; Shintre, P.; et al. Genome-wide Analysis Correlates Ayurveda Prakriti. Sci. Rep. 2015, 5, 15786</ref>

'''Risk factor (disease vulnerability) and prakriti:''' There is a close link between [[vata]]-[[kapha]] and [[kapha]] prakriti and risk factors (diabetes, hypertension, dyslipidemia), insulin resistance, and immune markers.<ref>Mahalle NP, Kulkarni MV, Pendse NM, Naik SS. Association of constitutional type of Ayurveda with cardiovascular risk factors, inflammatory markers and insulin resistance. J Ayurveda Integr Med 2012;3:150-7.</ref>There is a very strong link between prakriti (Kapha/KaphaPittaja) and type 2 diabetes.<ref>18. Gupta A, Ali A, Tewari P, Agrawal NK, Patel R, Byadgi PS. Association of Kaphaja and Kapha Pittaja Prakriti and methylenetetrahydrofolate reductase C677T allele with type 2 diabetes. Ayu2018;39:146-50.</ref>

'''Risk factor (disease vulnerability) and prakriti:''' There is a close link between [[vata]]-[[kapha]] and [[kapha]] prakriti and risk factors (diabetes, hypertension, dyslipidemia), insulin resistance, and immune markers.<ref>Mahalle NP, Kulkarni MV, Pendse NM, Naik SS. Association of constitutional type of Ayurveda with cardiovascular risk factors, inflammatory markers and insulin resistance. J Ayurveda Integr Med 2012;3:150-7.</ref>There is a very strong link between prakriti (Kapha/KaphaPittaja) and type 2 diabetes.<ref>Gupta A, Ali A, Tewari P, Agrawal NK, Patel R, Byadgi PS. Association of Kaphaja and Kapha Pittaja Prakriti and methylenetetrahydrofolate reductase C677T allele with type 2 diabetes. Ayu2018;39:146-50.</ref>

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